期刊
DIGESTIVE DISEASES
卷 33, 期 5, 页码 642-647出版社
KARGER
DOI: 10.1159/000438473
关键词
Hepatocellular carcinoma; Metabolic syndrome; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Cryptogenic cirrhosis; Phospholipase domain-containing 3
资金
- national advisory board Peregrine
Within developed countries the incidence of hepatocellular carcinoma (HCC) has been progressively increasing despite diagnosing fewer new cases of cirrhosis linked to viral hepatitis and alcohol consumption. This increased incidence parallels the epidemic of morbid obesity and metabolic syndrome and may be secondary to non-alcoholic steatohepatitis (NASH)-related HCC. The aims of this chapter are to (1) define the natural history of non-alcoholic fatty liver disease/NASH, (2) discuss the relationship between cryptogenic cirrhosis and NASH-related cirrhosis, (3) compare the presentation and treatment of NASH-related HCC to viral hepatitis-related cirrhosis and (4) identify the genetic factors associated with NASH and NASH-related HCC. (C) 2015 S. Karger AG, Basel
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