Article
Medicine, Research & Experimental
Shuze Chen, Xiuying Liu, Zhi Wang, Dekai Zheng, Ying Wang, Yiling Yan, Xiaojie Peng, Qiujuan Ye, Ye Chen
Summary: Through transcriptome analysis of human duodenal tissue, it was discovered that pyroptosis, a form of inflammatory cell death, is involved in the pathogenesis of celiac disease (CeD). The study also identified a T cell subset and signaling pathways associated with pyroptosis. This research provides novel evidence for the diagnosis and treatment of CeD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Shuo-Wang Qiao, Shiva Dahal-Koirala, Linn M. Eggesbo, Knut E. A. Lundin, Ludvig M. Sollid
Summary: Chronic inflammation in celiac disease is caused by CD4+ T cells recognizing gluten peptides presented by HLA-DQ molecules. Direct cell cloning from duodenal biopsies showed a high frequency of gluten-reactive T cells in active disease lesions, many of which are reactive to unidentified T-cell epitopes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Asbjorn Christophersen, Stephanie Zuhlke, Eivind G. Lund, Omri Snir, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Jorgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid
Summary: The study found that after a 3-day gluten challenge in celiac disease patients, the phenotypic profile of gluten-specific cells undergoes profound changes with exposure to gluten, overlapping with that of untreated disease. This antigen-induced shift in phenotype of CD4(+) T cells is shared with other disease-associated T cells, which is relevant for the development of T-cell-directed therapies.
Review
Pathology
Rasmus Iversen, Ludvig M. Sollid
Summary: Among HLA-associated disorders, celiac disease is well understood in terms of immunopathogenesis. This disease is characterized by hypersensitivity to gluten proteins and affects the gut. Diagnosis can be made by detecting autoantibodies to transglutaminase 2 in the blood. This review provides insights into the immunobiology of this common disorder that lies between food hypersensitivity and autoimmunity.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2023)
Correction
Chemistry, Multidisciplinary
Asbjorn Christophersen, Stephanie Zuhlke, Eivind G. Lund, Omri Snir, Shiva Dahal-Koirala, Louise Fremgaard Risnes, Jorgen Jahnsen, Knut E. A. Lundin, Ludvig M. Sollid
Summary: This study provides an in-depth characterization of gluten-specific CD4(+) T cells and CeD-associated CD8(+) and gamma delta(+) T cells in treated CeD patients. The phenotypic profile of gluten-specific cells changes profoundly with gluten exposure, showing similarities with untreated disease cells and CeD-associated T cells.
Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Food Science & Technology
Xiaoxue Zhu, Xin-Huai Zhao, Qiang Zhang, Na Zhang, Olugbenga P. Soladoye, Rotimi E. Aluko, Yuhao Zhang, Yu Fu
Summary: This article reviews the latest research progress on the relationship between celiac disease (CD) and gluten. It emphasizes the structure and function of gluten peptides related to CD, gluten detection methods, the effects of processing on gluten, and gluten-free diets. The limitations in current CD research are also discussed. This study facilitates a comprehensive understanding of CD and gluten, providing a theoretical reference for future research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Benjamin Lebwohl, Alberto Rubio-Tapia
Summary: The incidence of celiac disease is increasing due to both improved recognition and a real increase of the disorder. The reasons for this true rise are unclear, but may be related to environmental factors. Early-life gluten exposure is a major focus of prevention efforts.
Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Review
Immunology
Renata Auricchio, Riccardo Troncone
Summary: Celiac disease is an autoimmune disorder triggered by gluten, with prevention strategies focusing on identifying at-risk individuals and eliminating risk factors. Research has shown that both genetic and environmental factors play a role in the development of the disease, suggesting that future interventions could involve protection from infections, manipulation of microbiota, and modulation of T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Peter H. R. Green, Shirley Paski, Cynthia W. Ko, Alberto Rubio-Tapia
Summary: This article summarizes the diagnosis and management of refractory celiac disease, providing guidance on evaluation, nutritional support, potential therapeutic options, and surveillance for complications. The article emphasizes the importance of regular follow-up and multidisciplinary care for patients with refractory celiac disease.
Review
Biochemistry & Molecular Biology
Maider Garnica, Anna Aiello, Mattia Emanuela Ligotti, Giulia Accardi, Hugo Arasanz, Ana Bocanegra, Ester Blanco, Anna Calabro, Luisa Chocarro, Miriam Echaide, Grazyna Kochan, Leticia Fernandez-Rubio, Pablo Ramos, Fanny Pojero, Nahid Zareian, Sergio Pineiro-Hermida, Farzin Farzaneh, Giuseppina Candore, Calogero Caruso, David Escors
Summary: The number of people aged 65 or older is increasing, but their quality of life is not improving. Older people have a weaker immune system due to immunosenescence, making them more vulnerable to infections. This article reviews the impact of aging on T and B cells and discusses approaches to modulate and reverse the decline of the aging adaptive immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Xingxing Wu, Lin Qian, Kexin Liu, Jing Wu, Zhaowei Shan
Summary: Coeliac disease is an autoimmune intestinal disease induced by gluten, and adherence to gluten-free diet is an effective treatment. The gut microbiota plays a crucial role in maintaining health, which is regulated by diet. There is a need for alternative treatments to GFD due to the increasing prevalence of coeliac disease.
ANNALS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mariana Verdelho Machado
Summary: Celiac disease (CD) is a common autoimmune disease, affecting approximately 1% of the population. Regardless of symptoms, all CD patients must adhere to a lifelong gluten-free diet (GFD). However, this can be challenging due to a lack of gluten awareness in foods and the widespread use of gluten in processed foods. Research has been conducted to find pharmacological treatment for CD, but achieving full histological recovery on a GFD remains difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Maria de Lourdes Moreno
Summary: The only current treatment for celiac disease is a strict gluten-free diet, but there is a need for non-dietary alternatives to prevent damage from dietary transgressions. Recent therapies for CD focus on degrading gluten, regulating the immune response, and inducing immunological tolerance, with promising results seen in some phase III and II clinical trials.
Article
Medical Laboratory Technology
Rolf A. Klaasen, David J. Warren, Rasmus Iversen, Nils Bolstad, Ina L. Andersen, Patricia Mjones, Elin Ronne, Knut E. A. Lundin, Ludvig M. Sollid, Eivind Ness - Jensen
Summary: In this study, a robust and automated assay for screening celiac disease in the general population was developed and clinically validated. The use of higher cut-offs improved the accuracy of diagnosis.
CLINICAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Laura Ciacchi, Carine Farenc, Shiva Dahal-Koirala, Jan Petersen, Ludvig M. Sollid, Hugh H. Reid, Jamie Rossjohn
Summary: This study investigates the T-cell receptor specificity and cross-reactivity of two immunodominant wheat gluten epitopes in celiac disease. The researchers find that the differences in binding between the epitopes and T-cell receptors at position 7 explain the cross-reactivity between the two epitopes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Christian B. Lindstad, M. Fleur du Pre, Jorunn Stamnaes, Ludvig M. Sollid
Summary: The results of the study suggest that secreted anti-TG2 antibodies do not have a direct role in the development of celiac enteropathy.
Article
Multidisciplinary Sciences
Jing Li, Maxim Zaslavsky, Yapeng Su, Jing Guo, Michael J. Sikora, Vincent van Unen, Asbjorn Christophersen, Shin-Heng Chiou, Liang Chen, Jiefu Li, Xuhuai Ji, Julie Wilhelmy, Alana M. McSween, Brad A. Palanski, Venkata Vamsee Aditya Mallajosyula, Nathan A. Bracey, Gopal Krishna R. Dhondalay, Kartik Bhamidipati, Joy Pai, Lucas B. Kipp, Jeffrey E. Dunn, Stephen L. Hauser, Jorge R. Oksenberg, Ansuman T. Satpathy, William H. Robinson, Cornelia L. Dekker, Lars M. Steinmetz, Chaitan Khosla, Paul J. Utz, Ludvig M. Sollid, Yueh-Hsiu Chien, James R. Heath, Nielsen Q. Fernandez-Becker, Kari C. Nadeau, Naresha Saligrama, Mark M. Davis
Summary: The study reveals that CD8(+) T cells expressing inhibitory receptors play a regulatory role in immune responses in both humans and mice, and their increased presence is observed in various autoimmune diseases and COVID-19 patients. The findings suggest that these regulatory CD8(+) T cells are involved in suppressing pathogenic T cells in autoimmune and infectious diseases.
Review
Pathology
Rasmus Iversen, Ludvig M. Sollid
Summary: Among HLA-associated disorders, celiac disease is well understood in terms of immunopathogenesis. This disease is characterized by hypersensitivity to gluten proteins and affects the gut. Diagnosis can be made by detecting autoantibodies to transglutaminase 2 in the blood. This review provides insights into the immunobiology of this common disorder that lies between food hypersensitivity and autoimmunity.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2023)
Editorial Material
Gastroenterology & Hepatology
Knut E. A. Lundin, Peter H. R. Green
Article
Gastroenterology & Hepatology
Ludvig M. Sollid, Rasmus Iversen
Summary: Polymeric IgA and IgM are transported across the epithelial barrier from plasma cells in the lamina propria to exert a function in the gut lumen as secretory antibodies. T cells play a crucial role in the production of bacteria-reactive secretory antibodies, which are important for regulating gut bacterial communities.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jostein H. Ibsen, Adity Chopra, Eline Benno Vaage, John T. Vaage, Fridtjof Lund-Johansen, Knut E. A. Lundin
Summary: This study investigated the humoral response to SARS-CoV-2 vaccines in patients with celiac disease (CeD) and compared it with healthy controls. The results showed that the humoral response in CeD patients is similar to that observed in healthy controls.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Nader Atlasy, Anna Bujko, Espen S. Baekkevold, Peter Brazda, Eva Janssen-Megens, Knut E. A. Lundin, Jorgen Jahnsen, Frode L. Jahnsen, Hendrik G. Stunnenberg
Summary: This study characterizes the immune cell compartment of the human small intestine during active Celiac disease using single cell transcriptomics. The results show altered myeloid cell transcriptomes and extensive changes in CD4(+) and CD8(+) T cell transcriptomes. In addition, a reduced population of natural intraepithelial lymphocytes is observed in Celiac disease.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Marketa Chlubnova, Asbjorn O. Christophersen, Geir Kjetil F. Sandve, Knut E. A. Lundin, Jorgen Jahnsen, Shiva Dahal-Koirala, Ludvig M. Sollid
Summary: 42 wheat gluten-reactive T cell clones with different phenotypes and no reactivity to known epitopes were screened. Synthetic peptides were identified bioinformatically from a wheat gluten protein database and tested against the T cell clones. Reactivity of 10 T cell clones was assigned, and 5 previously uncharacterized gliadin/glutenin epitopes with a 9-nucleotide oligomer core region were identified. This work represents an advance in identifying CeD-driving gluten epitopes.
Article
Nutrition & Dietetics
Frida van Megen, Maria Fossli, Gry I. Skodje, Monica H. Carlsen, Lene F. Andersen, Marit B. Veierod, Knut E. A. Lundin, Christine Henriksen
Summary: A study on women with celiac disease and ongoing symptoms revealed that their dietary intake was unbalanced, with higher intake of fat and lower intake of protein and dietary fiber. This highlights the importance of nutritional follow-up for celiac patients and the development of nutrient-dense gluten-free products.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Anne Mari Herfindal, Frida van Megen, Mari K. O. Gilde, Jorgen Valeur, Knut Rudi, Gry I. I. Skodje, Knut E. A. Lundin, Christine Henriksen, Siv Kjolsrud Bohn
Summary: Individuals with CeD often experience gastrointestinal symptoms despite adherence to a GFD. The LFD may lead to changes in the faecal microbiota profile, but does not significantly affect gut integrity and inflammation markers in GFD-treated CeD patients.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Julie Elisabeth Heggelund, Saykat Das, Jorunn Stamnaes, Rasmus Iversen, Ludvig M. Sollid
Summary: The study presents four X-ray crystal structures of human TG3 in both inactive and active conformations, as well as the 3D structure of a TG3-specific antibody derived from a DH patient bound to TG3. The findings show that cleaved TG3 undergoes conformational changes upon binding to a substrate-mimicking inhibitor, which is recognized by DH autoantibodies. This supports a model where TG3-specific B-cell receptors bind and internalize TG3-gluten enzyme-substrate complexes, facilitating gluten-antigen presentation, T-cell help, and autoantibody production.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Lisa Garnweidner-Holme, Monica Hellmann, Christine Henriksen, Elisabeth Austad, Solveig Ivara Watters, Line Gaundal, Knut E. A. Lundin, Mari C. W. Myhrstad, Vibeke H. Telle-Hansen, Jana Pexova Kalinova
Summary: This study investigated the experiences of people with coeliac disease (CeD) with gluten-free bread, and found that they preferred fibre-rich gluten-free bread that is satiating and has a good texture.