Drug therapy targeting pyrophosphate slows the ossification of spinal ligaments in twy mice

Pyrophosphate: a key inhibitor of mineralisation

(2016) Isabel R Orriss et al.   CURRENT OPINION IN PHARMACOLOGY

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the HumanACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation

(2016) Salin A Chakkalakal et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prevalence, Concomitance, and Distribution of Ossification of the Spinal Ligaments

(2016) Takahito Fujimori et al.   SPINE

Teriparatide Improves Trabecular Osteoporosis but Simultaneously Promotes Ankylosis of the Spine in the Twy Mouse Model for Diffuse Idiopathic Skeletal Hyperostosis

(2015) Hiroki Hamano et al.   CALCIFIED TISSUE INTERNATIONAL

A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine

(2014) Masahiro Nakajima et al.   NATURE GENETICS

Inhibitors of tissue-nonspecific alkaline phosphatase: Design, synthesis, kinetics, biomineralization and cellular tests

(2013) Julien Debray et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy

(2011) Kenzo Uchida et al.   EUROPEAN SPINE JOURNAL

Initiation and progression of ossification of the posterior longitudinal ligament of the cervical spine in the hereditary spinal hyperostotic mouse (twy/twy)

(2011) Kenzo Uchida et al.   EUROPEAN SPINE JOURNAL

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists

(2011) Kengo Shimono et al.   NATURE MEDICINE

Treatment with pyrophosphate inhibits uremic vascular calcification

(2010) W Charles O'Neill et al.   KIDNEY INTERNATIONAL