期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 7, 页码 3631-3638出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00148
关键词
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资金
- National Natural Science Foundation of China [21572162, 21472140]
- Natural Science Foundation of Zhejiang Province [LY16B020012]
- Science and Technology Project of Zhejiang Province [2016C31022]
- Xinmiao Talent Planning Foundation of Zhejiang Province [2016R426059, 2016R426058]
A palladium-catalyzed tandem addition/cyclization of 2-(2-aminoaryl)acetonitriles with arylboronic acids has been developed for the first time, achieving a new strategy for direct construction of indole skeletons. This system shows good functional group tolerance and remarkable chemoselectivity. In particular, the halogen (e.g., bromo and iodo) substituents are amenable to further synthetic elaborations thereby broadening the diversity of the products. Preliminary mechanistic experiments indicate that this transformation involves sequential nucleophilic addition followed by an intramolecular cydization.
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