期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 2, 页码 1145-1154出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.6b02767
关键词
-
资金
- Natural Science Foundation of China [21372174, 21672157]
- Ph.D. Programs Foundation of Ministry of Education of China [2013201130004]
- Innovation Project for Graduate Student of Jiangsu Province [KYZZ15_0322]
- PAPD
- Soochow University
An efficient method for the modular synthesis of various pyrimidine derivatives by means of the reactions of ketones, aldehydes, or esters with amidines in the presence of an in situ prepared recyclable iron(II)-complex was developed. This operationally simple reaction proceeded with broad functional group tolerance in a regioselective manner via a remarkable unactivated beta-C-H bond functionalization. Control experiments were performed to gain deep understanding of the mechanism, and the reactions are likely to proceed through a designed TEMPO complexation/enamine addition/transient alpha-occupation/beta-TEMPO elimination/cyclization sequence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据