期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 23, 页码 12503-12510出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02288
关键词
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资金
- JSPS KAKENHI [16H03285]
- Grants-in-Aid for Scientific Research [16H03285, 16K13091] Funding Source: KAKEN
The total synthesis of kanamienamide, an enamide with an enol ether and an 11-membered macrolactone of marine origin, was achieved. The synthesis features the construction of an enamide adjacent to an enol ether by Buchwald amidation and an 11-membered ring by Mitsunobu lactonization. In addition, on the basis of the biological assay of synthetic 1, we clarified that kanamienamide (1) was not an apoptosis-like cell death inducer, as reported in the isolation paper, and revealed its real biological activity as a necrosis-like cell death inducer.
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