期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 82, 期 13, 页码 6958-6967出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b00639
关键词
-
资金
- National Institutes of Health Institute of General Medical Sciences [2R01GM90082-A1]
A regioselective base-mediated cyclization of mono-N-acylpropargylguanidines is reported. A related Ag(I)-catalyzed hydroamination strategy was recently employed to yield N-3-Cbz-protected ene-guanidines, which found utility in the synthesis of naamidine A. Herein, we report the base-catalyzed hydroamination of mono-N-acylpropargylguanidines, which proceeds with the opposite regiochemistry to deliver isomerized N-2-acyl-2-aminoimidazoles with broad substrate scope, circumventing the problematic regiospecific acylation of free 2-aminoimidazoles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据