Article
Biochemistry & Molecular Biology
Lorena Mazuecos, Cristina Pintado, Blanca Rubio, Eduardo Guisantes-Batan, Antonio Andres, Nilda Gallardo
Summary: The study demonstrates that PPAR beta/delta is involved in the up-regulation of FGF21 expression induced by leptin in visceral adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ashot Sargsyan, Ludivine Doridot, Sarah A. Hannou, Wenxin Tong, Harini Srinivasan, Rachael Ivison, Ruby Monn, Henry H. Kou, Jonathan M. Haldeman, Michelle Arlotto, Phillip J. White, Paul A. Grimsrud, Inna Astapova, Linus T. Tsai, Mark A. Herman
Summary: A study found that carbohydrate response element-binding protein (ChREBP) regulates the activity of hepatocyte growth factor activator (HGFAC) in the liver, promoting glucose and lipid homeostasis and playing an important role in adapting to overnutrition.
Review
Immunology
Yiliang Chen, Jue Zhang, Weiguo Cui, Roy L. Silverstein
Summary: CD36 functions as both a signaling receptor and fatty acid transporter in various immune and non-immune cells. This review summarizes how its dual functions determine immune cell functions and fates, which contribute to common diseases including atherosclerosis and tumor progression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Henry S. Kahn
Summary: BMI does not provide information about the relative size of adipose tissue depots, while SAD is associated with visceral fat accumulation, which may contribute to the estimation of cardiometabolic risk. SADHtR is more strongly associated with intermediary predictors of cardiometabolic disease.
Article
Endocrinology & Metabolism
Peng-Long Li, Mei Li, Zhenya Wang, Xiao-Ming Wang, Shuai-Yang Liu, Song Tian, Zhou-Xiang Wang, Xu Cheng, Yufeng Hu, Peng Zhang, Zhi-Gang She, Hailong Yang, Hongliang Li, Xiao-Jing Zhang
Summary: This study aims to identify promising drug candidates by targeting PPAR gamma for adipogenesis-based metabolic homeostasis and clarify the detailed mechanisms. Magnolol was identified as a potent adipogenesis activator by stabilizing PPAR gamma, providing a new avenue for the therapy of adipogenesis-related metabolic disorder.
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yingxi Xu, Tianhao Yu, Guojing Ma, Lixia Zheng, Xuehan Jiang, Fan Yang, Zhuo Wang, Na Li, Zheng He, Xiaoyu Song, Deliang Wen, Juan Kong, Yang Yu, Liu Cao
Summary: Berberine promotes the distribution of brown adipose tissue and thermogenesis, leading to reduced body weight and insulin resistance in high-fat diet mice. It activates the energy metabolic sensing pathway and increases the expression of thermogenic proteins in adipose tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.
Article
Biochemistry & Molecular Biology
Afifah Zahirah Abd Rami, Amilia Aminuddin, Adila A. Hamid, Mohd Helmy Mokhtar, Azizah Ugusman
Summary: This study found that nicotine reduces the anti-contractile effect of perivascular adipose tissue (PVAT) on blood vessels by inhibiting the PPARγ-adiponectin-adipoR1 axis. This may help explain the detrimental effects of nicotine on vascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Ahmet Mentese, Seniz Dogramaci, Selim Demir, Serap Ozer Yaman, Imran Ince, Diler Us Altay, Mehmet Erdem, Ibrahim Turane, Ahmet Alver
Summary: The study examined the impact of Hcy on gene and protein expression in adipose tissue, finding that CD36 gene expression increased in obese mice and decreased with Hcy supplementation. Both PPAR gamma and C/EBP alpha gene expression levels decreased in all groups compared to the normal group, with even lower levels when supplemented with Hcy.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Selin Gencer, Yvonne Doering, Yvonne Jansen, Soyolmaa Bayasgalan, Olga Schengel, Madeleine Mueller, Linsey J. F. Peters, Christian Weber, Emiel P. C. van der Vorst
Summary: This study reveals that adipocyte-specific ACKR3 plays a key role in regulating lipid levels in hyperlipidemic mice, potentially impacting the health of adipose tissue. On the other hand, hepatic ACKR3 deficiency did not show comparable effects on lipid levels in adipose tissue. Further research is needed to explore the systemic or metabolic effects of adipocyte ACKR3 in disease models.
Article
Cell Biology
Ying He, Ruotong Zhang, Lexiang Yu, Tarik Zahr, Xueming Li, Tae-Wan Kim, Li Qiang
Summary: Aging and obesity contribute to metabolic dysfunction, but the underlying mechanisms are still unclear. A study using a unique mouse model suggests that acetylation of PPARγ in adipocytes may play a role in worsened obesity, insulin resistance, and other metabolic deregulations associated with aging. The study also found that this acetylation may lead to whitening of brown adipose tissue and impair the function of the tissue. The results highlight the potential therapeutic target of adipocyte PPARγ acetylation in combating metabolic dysfunction.
Review
Immunology
Andres R. Munoz-Rojas, Diane Mathis
Summary: T-reg cells located in non-lymphoid tissues exhibit distinct transcriptomes, T cell receptor repertoires, and dependencies on growth factors which allow them to function effectively in their home tissue. These cells play crucial roles in tissue homeostasis, metabolism, tissue repair, and regulating the fate of non-lymphoid cell progenitors. Their specialized functions are influenced by transcriptional programs which differ based on the tissue environment, providing potential targets for precision immunotherapeutics.
NATURE REVIEWS IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Davia Prischich, Alexandre M. J. Gomila, Santiago Milla-Navarro, Gemma Sanguesa, Rebeca Diez-Alarcia, Beatrice Preda, Carlo Matera, Montserrat Batlle, Laura Ramirez, Ernest Giralt, Jordi Hernando, Eduard Guasch, J. Javier Meana, Pedro de la Villa, Pau Gorostiza
Summary: The paper introduces a first generation of photochromic ligands that can modulate physiological processes by manipulating adrenergic neurotransmission, demonstrating their control effects in zebrafish and mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Food Science & Technology
Karen Alejandra Mendez-Lara, Elisabeth Rodriguez-Millan, David Sebastian, Rosi Blanco-Soto, Mercedes Camacho, Madalina N. Nan, Elena M. G. Diarte-Anazco, Eugenia Mato, Silvia Lope-Piedrafita, Nuria Roglans, Juan Carlos Laguna, Nuria Alonso, Didac Mauricio, Antonio Zorzano, Francesc Villarroya, Josep A. Villena, Francisco Blanco-Vaca, Josep Julve
Summary: Nicotinamide (NAM) supplementation can protect against diet-induced obesity by increasing overall energy expenditure and altering adipose tissue morphology and metabolism, potentially offering a promising treatment for preventing obesity and associated complications.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Juan C. Laguna, Marta Alegret, Montserrat Cofan, Ana Sanchez-Tainta, Andres Diaz-Lopez, Miguel A. Martinez-Gonzalez, Jose V. Sorli, Jordi Salas-Salvado, Montserrat Fito, Angel M. Alonso-Gomez, Lluis Serra-Majem, Jose Laperra, Miquel Fiol, Enrique Gomez-Gracia, Xavier Pinto, Miguel A. Munoz, Olga Castaner, Judith B. Ramirez-Sabio, Jose J. Portu, Ramon Estruch, Emilio Ros
Summary: This study found an association between intake of simple sugars in drinks and fruit juice and increased risk of overall cancer incidence and mortality, suggesting that sugary beverages may be a modifiable risk factor for cancer and all-cause mortality.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Ana Magdalena Velazquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lazaro, Jose Rodriguez-Morato, Rosa M. Sanchez, Marta Alegret, Nuria Roglans, Juan Carlos Laguna
Summary: This study aims to determine the role of dietary saturated fatty acids (FA) versus liquid fructose in the development of fatty liver and hypertriglyceridemia. The results show that adding liquid fructose to the diet plays a decisive role in the accumulation of liver fat and production of high triglycerides, through increased de novo lipogenesis and reduced fatty acid catabolism.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Peripheral Vascular Disease
Roger Bentanachs, Ana Magdalena Velazquez, Rosa Maria Sanchez, Marta Alegret, Juan Carlos Laguna, Nuria Roglans
Summary: Bempedoic acid appears to be an effective treatment for fatty liver and associated cardiovascular risk. It works by activating peroxisome proliferator-activated nuclear receptor (PPARa) and other mechanisms to reduce hepatic steatosis and increase liver weight.
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2022)
Article
Biochemistry & Molecular Biology
Ana Magdalena Velazquez, Roger Bentanachs, Aleix Sala-Vila, Iolanda Lazaro, Jose Rodriguez-Morato, Rosa Maria Sanchez, Juan Carlos Laguna, Nuria Roglans, Marta Alegret
Summary: The study investigated the anti-steatotic effect of Bempedoic acid (BemA) in a rat model of fatty liver induced by a high-fat diet supplemented with liquid fructose. The results showed that BemA-treated rats exhibited lower body weight, higher liver/body weight, and reduced hepatic steatosis compared to the control group. In addition to inhibiting ATP-citrate lyase (ACLY), BemA was found to have three novel mechanisms, including reducing fructose intake and de novo lipogenesis, increasing liver triglyceride export, and promoting hepatic fatty acid beta-oxidation. These findings suggest that BemA may be a potential approach for treating hepatic steatosis and preventing the progression of non-alcoholic fatty liver disease.
Article
Cardiac & Cardiovascular Systems
Cira Rubies, Montserrat Batlle, Maria Sanz-de la Garza, Ana-Paula Dantas, Ignasi Jorba, Guerau Fernandez, Gemma Sanguesa, Marc Abuli, Josep Brugada, Marta Sitges, Daniel Navajas, Lluis Mont, Eduard Guasch
Summary: Moderate exercise has well-established benefits for cardiovascular health, but intense training may diminish these benefits by causing adverse remodeling of blood vessels and heart arteries.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Gemma Sanguesa, Montserrat Batlle, Emma Munoz-Moreno, Guadalupe Soria, Anna Alcarraz, Cira Rubies, Laia Sitja-Roqueta, Elisabeth Solana, Eloy Martinez-Heras, Aline Meza-Ramos, Sergi Amaro, Sara Llufriu, Lluis Mont, Eduard Guasch
Summary: The study showed that strenuous long-term exercise may not improve learning ability as much as moderate exercise. Rats undergoing intense training displayed mitochondrial dysfunction in the cortex and an imbalance in antioxidant capacity.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Clara Bartra, Lars Andre Jager, Anna Alcarraz, Aline Meza-Ramos, Gemma Sanguesa, Ruben Corpas, Eduard Guasch, Montserrat Batlle, Coral Sanfeliu
Summary: Physically active lifestyle has significant implications for the health and well-being, but excessive training can lead to cardiovascular events and impaired brain plasticity. In this study, young adult male mice were subjected to moderate or high-intensity treadmill running for eight weeks. The high-intensity training resulted in decreased weight gain and cardiac hypertrophy, but without hemodynamic overload. It also reduced heart rate and improved motor skills, without impairing recognition or spatial memory.
Article
Biochemistry & Molecular Biology
Nuria Roglans, Elena Fauste, Roger Bentanachs, Ana M. Velazquez, Madelin Perez-Armas, Cristina Donis, Maria Panadero, Marta Alegret, Paola Otero, Carlos Bocos, Juan C. Laguna
Summary: In our study, we found that the HFHFr diet reduces the production of liver H2S, mainly by decreasing the expression of CBS and CSE. However, treatment with BemA restores H2S production by increasing the expression of CBS and CSE, suggesting the involvement of the FXR transcriptional activity and the mTORC1/S6K1/PGC1 alpha pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)