Article
Environmental Sciences
Xin Wang, Kelly M. Bakulski, Bhramar Mukherjee, Howard Hu, Sung Kyun Park
Summary: Chronic lead exposure has long-term health effects. Blood lead can be used to assess recent exposure, while bone lead can be used to assess chronic exposure. A machine learning approach called Super Learner was developed to predict bone lead concentrations by combining the predictions from multiple algorithms.
Article
Nutrition & Dietetics
Ligia J. Dominguez, Nicola Veronese, Eleonora Baiamonte, Martina Guarrera, Angela Parisi, Chiara Ruffolo, Federica Tagliaferri, Mario Barbagallo
Summary: Multiple factors, including genetics, behavior, environment, and diet, contribute to the complex process of aging. Nutritional factors have a significant impact on age-related chronic diseases and mortality. Recent nutrition research has shifted from focusing on single nutrients to considering food combinations and overall dietary patterns.
Article
Nutrition & Dietetics
Toshiko Tanaka, Sameera A. Talegawkar, Yichen Jin, Julian Candia, Qu Tian, Ruin Moaddel, Eleanor M. Simonsick, Luigi Ferrucci
Summary: Diet quality is associated with aging rates. This study identified metabolomic biomarkers of dietary patterns and explored their role in mediating the relationship between diet and healthy aging. Adherence to different dietary patterns was associated with lower frailty index. Multiple metabolite classes were associated with different dietary patterns, suggesting common mechanisms underlying the relationship between diet and frailty. These metabolites may serve as biomarkers for poor diet quality.
Review
Food Science & Technology
Hui Duan, Jiani Pan, Min Guo, Jinwei Li, Leilei Yu, Liuping Fan
Summary: Dietary intervention is a safe, broad-spectrum, and low-cost strategy for slowing aging. It regulates nutrient-sensing pathways, gut microbiota, metabolism, and immunity. Different dietary patterns and supplements, as well as the proportion of macronutrients, have varying effects on aging.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Yifei Ouyang, Tingyi Tan, Xiaoyun Song, Feifei Huang, Bing Zhang, Gangqiang Ding, Huijun Wang
Summary: The study found a significant decrease in dietary protein intake among the elderly Chinese population over a 28-year period, with cereals and meat as the main sources and an increase in the proportion of energy gained from fat. Despite positive effects on protein quality due to dietary pattern changes, some elderly Chinese individuals may face the risk of inadequate dietary protein intake.
Article
Environmental Sciences
Tingxin Li, Jian Xie, Ping Shuai, Jie Huang, Baoming He
Summary: The present study investigated the correlation between dietary patterns (DPs) with skeletal muscle mass (SMM) and cardiovascular risks in Sichuan males aged >= 65-years-old. The results showed that animal-based and processed food DP was positively associated with overweight/obesity and dyslipidemia, while traditional DP was negatively associated with these risks. Ovo-lacto vegetarian DP was negatively associated with dyslipidemia and hyperuricemia.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Shravanthi M. Seshasayee, Sheryl L. Rifas-Shiman, Jorge E. Chavarro, Jenny L. Carwile, Pi-I D. Lin, Antonia M. Calafat, Sharon K. Sagiv, Emily Oken, Abby F. Fleisch
Summary: This study examined the association between children's diet and PFAS, finding that intake of ice cream and soda was associated with higher plasma concentrations of specific PFAS. A dietary pattern consisting of primarily packaged foods and fish was identified to be correlated with higher PFAS concentrations. Further investigation is needed to inform measures to modify childhood PFAS exposure.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Yifei Ouyang, Feifei Huang, Xiaofan Zhang, Li Li, Bing Zhang, Zhihong Wang, Huijun Wang
Summary: This cross-sectional study investigates the association between dietary protein intake and muscle mass in elderly Chinese adults. The results show that high total protein intake and high plant-based protein intake are positively associated with higher muscle mass. Therefore, it is encouraged to increase daily protein intake to maintain muscle health in the elderly.
Article
Physiology
Jinfeng Zhao, Yanfeng Ding, Geoffrey P. Kline, Zhengyang Zhou, Robert T. Mallet, Xiangrong Shi
Summary: The study revealed that elderly women experience more intense hypoxemia and reduced chemoreflex sensitivity during brief hypoxia breathing compared to elderly men. Although women show a faster decrease in oxygen saturation per unit decrease in end-tidal oxygen pressure, their minute ventilation increases less significantly, leading to a decrease in oxygen extraction fraction (OEF) stability in women.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Summary: This study found that even with relatively low intake of whey protein, there is a risk of blood pressure decrease in older men.
Article
Nutrition & Dietetics
Zhen Liu, Di Xu, Wen-xiu Xu, Yin-jiao Fei, Dan-dan Wang, Fei Deng, Jin-hai Tang
Summary: This study investigates the relationships between different dietary patterns or nutritional status and mortality risk in individuals. The results suggest that higher healthy eating index and lower dietary inflammatory index are associated with lower mortality risk in people aged over 60 in the United States, while excessively low nutritional status increases the risk of death.
FRONTIERS IN NUTRITION
(2022)
Review
Geriatrics & Gerontology
Ligia J. Dominguez, Nicola Veronese, Mario Barbagallo
Summary: Nutrition plays a significant role in healthy aging and longevity. The focus of research has shifted from isolated nutrients or foods to dietary patterns. Plant-based dietary patterns are associated with reduced risk of age-associated chronic diseases and frailty, promoting healthy aging. On the other hand, diets high in ultra-processed food are linked to unhealthy aging.
Article
Nutrition & Dietetics
Miika M. Wynne-Ellis, Jaakko J. Mursu, Tomi-Pekka Tuomainen, Elizabeth Bertone-Johnson, Jukka T. Salonen, Jyrki K. Virtanen
Summary: The quality of dietary fat was not independently associated with serum androgen concentrations in middle-aged men. However, replacing protein with saturated fatty acids may be associated with higher serum androgen concentrations.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Robert Gajda, Marzena Jezewska-Zychowicz, Ewa Raczkowska
Summary: This study aimed to assess the diversity of dietary patterns among 427 Polish elderly individuals aged 60 and older, taking into account their region of residence, household structure, and socioeconomic status. The findings revealed that adherence to specific dietary patterns was associated with socioeconomic status and living environment, while region did not play a significant role. Elderly individuals living with family were more likely to follow both prudent and adverse dietary patterns. High socioeconomic status decreased adherence to certain dietary patterns, while living with family increased adherence to others. Identifying dietary patterns in the elderly can help guide public policies and nutritional counseling for this age group.
Article
Endocrinology & Metabolism
Aleksandra Ryl, Aleksandra Szylinska, Andrzej Bohatyrewicz, Alina Jurewicz, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Iwona Rotter
Summary: This study investigated the relationships between serum and bone concentrations of bioelements and lead, and indicators of metabolic disorders. The results showed that there were no significant relationships between these concentrations and BMI. However, bone Mg was significantly higher in men with higher VAI, and bone Cu, Zn, and Mg were higher in patients with higher LAP. Further multivariate logistic regression analysis revealed correlations between specific elements and cut-off points for VAI and LAP.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Nutrition & Dietetics
Nicole A. Karazurna, Caitlin M. Porter, Semra Aytur, Tammy Scott, Josiemer Mattei, Sabrina E. Noel, Hector M. Gonzalez, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Linda C. Gallo, Martha L. Daviglus, Linda Van Horn, Tali Elfassy, Marc D. Gellman, Ashley E. Moncrieft, Katherine L. Tucker, Robert C. Kaplan, Sherman J. Bigornia
Summary: The study aimed to investigate the association between dietary fatty acid patterns and cognitive function among Hispanic/Latino adults. The results suggest that the consumption of short to medium-chain SFA may be associated with higher cognitive function.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Neha Sahasrabudhe, Jong Soo Lee, Xiyuan Zhang, Tammy Scott, Laura Punnett, Katherine L. Tucker, Natalia Palacios
Summary: Higher adherence to the Mediterranean diet is associated with lower depressive symptoms, including among Latino populations such as Puerto Ricans in mainland U.S. This study found that adherence to the Mediterranean diet was negatively associated with self-reported depressive symptoms among Puerto Rican adults in the Boston area.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jan Philipp Schuchardt, Marianna Cerrato, Martina Ceseri, Laura F. DeFina, Graciela E. Delgado, Sandra Gellert, Andreas Hahn, Barbara V. Howard, Aya Kadota, Marcus E. Kleber, Roberto Latini, Winfried Maerz, JoAnn E. Manson, Samia Mora, Yongsoon Park, Aleix Sala-Vila, Clemens von Schacky, Akira Sekikawa, Nathan Tintle, Katherine L. Tucker, Ramachandran S. Vasan, William S. Harris
Summary: Red blood cell fatty acid patterns are recognized as long-term biomarkers of tissue fatty acid composition. This study investigated RBC fatty acid data from seven countries and found that most countries had a low Omega-3 Index, with only South Korea and Japan showing desirable levels. The study suggests that countries conducting national health studies should use a uniform method to measure Omega-3 fatty acid levels.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Sona Rivas-Tumanyan, Lorena S. Pacheco, Danielle E. Haslam, Liming Liang, Katherine L. Tucker, Kaumudi J. Joshipura, Shilpa N. Bhupathiraju
Summary: This study assessed the longitudinal associations between plasma metabolites, their network-derived clusters, and the progression of type 2 diabetes (T2D) in Puerto Rican adults. The findings highlight potential prognostic biomarkers for identifying high-risk individuals and suggest the need for further research on the role of diet and lifestyle in modifying these associations.
Letter
Endocrinology & Metabolism
Sung Kyun Park, Xin Wang, Carrie A. Karvonen-Gutierrez
Article
Nutrition & Dietetics
Nayla Bezares, Amanda C. McClain, Martha Tamez, Jose F. Rodriguez-Orengo, Katherine L. Tucker, Josiemer Mattei
Summary: This study examined the association between frequency and type of consuming foods away from home (FAFH) and diet quality in adults in San Juan, Puerto Rico. The results showed that frequent FAFH consumption was associated with lower diet quality and lower adherence to dietary recommendations. Future studies should explore strategies to improve diet quality, such as prioritizing healthy at-home meals and improving the quality of commercial FAFH.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Environmental Sciences
Xin Wang, Kelly M. Bakulski, Bhramar Mukherjee, Howard Hu, Sung Kyun Park
Summary: Chronic lead exposure has long-term health effects. Blood lead can be used to assess recent exposure, while bone lead can be used to assess chronic exposure. A machine learning approach called Super Learner was developed to predict bone lead concentrations by combining the predictions from multiple algorithms.
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph, Bhramar Mukherjee, Ellen B. Gold, Sung Kyun Park
Summary: Exposure to heavy metals may affect sex hormone levels in women. This study analyzed the association between urinary metal concentrations and serum levels of estradiol (E-2), follicle-stimulating hormone (FSH), testosterone, and sex hormone-binding globulin (SHBG) in a multi-ethnic group of women aged 45-56 years. The results showed that higher urinary metal concentrations were linked to lower E-2 levels for mercury and lead, higher FSH levels for lead, and higher SHBG levels for cadmium. However, no significant association was found between metals and testosterone levels.
ENVIRONMENTAL POLLUTION
(2023)
Article
Geriatrics & Gerontology
Deepika Dinesh, Jong Soo Lee, Tammy M. Scott, Katherine L. Tucker, Natalia Palacios
Summary: This study conducted among Boston Puerto Ricans found no association between proton pump inhibitor (PPI) use and global cognition, executive function, or memory, both cross-sectionally and over 12.7 years of follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sha Hua, Bomin Lv, Zeping Qiu, Zhuojin Li, Zhiyan Wang, Yanjia Chen, Yanxin Han, Katherine L. Tucker, Hao Wu, Wei Jin
Summary: This study aimed to identify microbial signatures that contribute to the shared etiologies between chronic heart failure (CHF), type 2 diabetes, and chronic kidney disease. The serum levels of 151 microbial metabolites were measured in 260 individuals from the Risk Evaluation and Management of heart failure cohort, and it was found that those metabolites varied by an order of 10(5) fold. Key microbial metabolite-based risk scores were superior in CHF prognosis than the traditional Framingham or Get with the Guidelines-Heart Failure risk scores. Interactive visualization of these specific metabolite-disease links is available on our omics data server ().
EMBO MOLECULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ruth J. Geller, Amelia K. Wesselink, Martha R. Koenig, Michael L. Eisenberg, Katherine L. Tucker, Elizabeth E. Hatch, Lauren A. Wise
Summary: This study found weak positive associations between male fatty acid intake and fecundability among couples planning pregnancy. However, no other fatty acid subtypes were significantly associated with fecundability. This study fills a knowledge gap regarding the association between male fatty acid intake and fecundability.
HUMAN REPRODUCTION
(2023)
Article
Nutrition & Dietetics
Liam E. Fouhy, Kelsey M. Mangano, Xiyuan Zhang, Bess Dawson Hughes, Katherine L. Tucker, Sabrina E. Noel
Summary: This study aimed to investigate the association between the calcium-to-magnesium intake ratio and bone mineral density (BMD) and osteoporosis in Puerto Rican adults. The results showed that the highest and lowest tertiles of calcium intake had higher odds of osteoporosis compared to the middle tertile.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Andrea Lopez-Cepero, Katherine L. Tucker, Jose F. Rodriguez-Orengo, Josiemer Mattei
Summary: A diet high in quality is essential for preventing chronic diseases. This study examined the eating behaviors and their associations with nutrient intake and diet quality in Puerto Rican adults. The results showed that engaging in healthy eating behaviors was linked to better diet quality and lower intake of unfavorable nutrients.
NUTRITION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Inyene E. Essien-Aleksi, Yuan Zhang, Ainat Koren, Natalia Palacios, Luis M. Falcon, Katherine L. Tucker
Summary: The study found a high prevalence of prescription opioid use among Puerto Rican adults (PRs), with persistent use significantly associated with perceived discrimination. Future plans should focus on reducing discrimination practices to reduce the persistent use of prescription opioids and related complications among PRs.
Article
Nutrition & Dietetics
Toshiko Tanaka, Jayanta K. Das, Yichen Jin, Qu Tian, Ruin Moaddel, Ann Zenobia Moore, Katherine L. Tucker, Sameera A. Talegawkar, Luigi Ferrucci
Summary: This study explores the role of circulating metabolites in mediating the relationship between dietary protein and frailty. The results suggest that higher intake of plant protein is associated with lower levels of frailty, while animal protein does not show such association. The study also identifies specific metabolites, such as lipid metabolites and tryptophan-related metabolites, that mediate the protective effect of plant protein on frailty.