Article
Gastroenterology & Hepatology
Moritz Leppkes, Aylin Lindemann, Stefanie Goesswein, Susanne Paulus, Dominik Roth, Anne Hartung, Eva Liebing, Sebastian Zundler, Miguel Gonzalez-Acera, Jay Patankar, Fabrizio Mascia, Kristina Scheibe, Markus Hoffmann, Stefan Uderhardt, Christine Schauer, Sebastian Foersch, Clemens Neufert, Michael Vieth, Georg Schett, Raja Atreya, Anja A. Kuehl, Andre Bleich, Christoph Becker, Martin Herrmann, Markus F. Neurath
Summary: Bleeding ulcers and erosions are common in active ulcerative colitis, with fibrin layers correlated with rectal bleeding. Neutrophils induce secondary immunothrombosis through PAD4-dependent mechanisms, protecting against acute colitis and rectal bleeding. Deficiency in immunothrombosis can lead to exacerbated colitis and increased bleeding.
Article
Hematology
Ryan C. Lynch, Chaitra S. Ujjani, Christina Poh, Edus H. Warren, Stephen D. Smith, Mazyar Shadman, Brian Till, Vikram M. Raghunathan, Stefan Alig, Ash A. Alizadeh, Avanti Gulhane, Delphine L. Chen, Yolanda Tseng, Hilary Coye, Megan Shelby, Susan Ottemiller, Sarith Keo, Kaitlin Verni, Hongyan Du, Jacquelin Vandermeer, Ashley Gaston, Heather Rasmussen, Paul Martin, Edmond Marzbani, Jenna Voutsinas, Ajay K. Gopal
Summary: This study investigated the concurrent administration of pembrolizumab with chemotherapy in untreated classic Hodgkin lymphoma, showing promising safety and efficacy. Although some patients experienced adverse events, the overall response rate was 100% with a complete response rate of 90%.
Review
Medicine, General & Internal
Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Shigeo Nakamura
Summary: Hodgkin lymphomas are lymphoid neoplasms characterized by dysplastic cells and interactions with the tumor microenvironment. Overexpression of CD274/PD-L1 is considered a defining feature of an HL subset, and targeting immune checkpoint molecules shows promise as a therapeutic option. However, the presence of multiple disease subtypes and overlap with morphological mimics poses challenging diagnostic and therapeutic problems in HLs.
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Gastroenterology & Hepatology
Michele Carvello, Vittoria Bellato, Annalisa Maroli, Ailsa Hart, Silvio Danese, Janindra Warusavitarne, Antonino Spinelli
Summary: Rectal cancer in patients with ulcerative colitis is a complex condition, but surgery can achieve excellent oncological and functional outcomes. Multidisciplinary collaboration among surgeons, gastroenterologists, and medical oncologists is crucial for determining the most appropriate treatment pathway for individual patients.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Virology
Ke Zhuang, Yongxi Zhang, Pingzheng Mo, Liping Deng, Yong Jiang, Lei Yu, Fanghua Mei, Shaoxin Huang, Xi Chen, Yajun Yan, Hongbin Tang, Xiangdong Li, Yong Xiong, Shuwen Wu, Hengning Ke, Xien Gui, Ke Lan
Summary: The identification of differentially expressed proteins in the plasma of patients with AIDS-NHL may lead to the development of biomarkers for screening, diagnosis, treatment, and prognosis. Immunoglobulin and complement components were found to be common proteins in this study. These proteins play a role in the pathogenesis of AIDS-NHL.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Hematology
Maria Maco, Kristyna Kupcova, Vaclav Herman, Iva Ondeckova, Tomas Kozak, Heidi Mocikova, Ondrej Havranek
Summary: Somatic mutations in genes involved in signaling pathways have been found to be important in the development of HL. Detection and analysis of ctDNA from HL tumor cells in the bloodstream shows promise as a non-invasive tool for tumor analysis and monitoring treatment response.
ANNALS OF HEMATOLOGY
(2022)
Article
Oncology
Bruno Sensi, Giulia Bagaglini, Vittoria Bellato, Daniele Cerbo, Andrea Martina Guida, Jim Khan, Yves Panis, Luca Savino, Leandro Siragusa, Giuseppe S. Sica
Summary: This article discusses the challenges in managing low rectal cancer in ulcerative colitis patients and provides a structured approach to this complex situation, including literature review, clinical experience, and management algorithm.
Article
Gastroenterology & Hepatology
Yu-Fei Lin, Chang Mu Sung, Huei-Mien Ke, Chia-Jung Kuo, Wei-an Liu, Wen-Sy Tsai, Cheng-Yu Lin, Hao-Tsai Cheng, Meiyeh J. Lu, Isheng J. Tsai, Sen-Yung Hsieh
Summary: This study investigated the mucosal tissue microbiomes in distinguishing patients with subclinical UC from healthy individuals, finding that rectal tissue microbiome was more effective than cecal tissue and fecal samples. Specific microbial compositions and functional pathways were identified in subclinical UC patients, suggesting the potential of rectal biopsy microbiome assessment in predicting disease progression and relapse in UC.
Article
Oncology
Victoria Menendez, Jose L. Solorzano, Sara Fernandez, Carlos Montalban, Juan F. Garcia
Summary: This article reviews the important immune populations in the cHL tumor microenvironment, focusing on their integrative functional signatures. The cHL microenvironment plays a significant role in tumor cell survival. HRS cells promote their survival through intrinsic and extrinsic alterations, leading to immunosuppression. cHL is proving to be an ideal model for studying immune checkpoint blockade, with druggable key signaling pathways identified. Additionally, numerous biomarkers for predicting treatment response await further validation.
Review
Oncology
Liwei Lv, Yuanbo Liu
Summary: Non-Hodgkin lymphoma (NHL) is a common hematological malignant tumor that can be diagnosed through invasive tissue biopsies, which have limitations in clinical applications. To overcome these limitations, liquid biopsies (LBs) have been proposed and shown to be applicable for diagnosis, treatment, prognosis, and monitoring of NHL.
FRONTIERS IN ONCOLOGY
(2021)
Review
Hematology
Carrie Ho, Marco Ruella, Bruce L. Levine, Jakub Svoboda
Summary: Although CAR T-cell therapy has been approved for B-cell non-Hodgkin lymphomas, the progress for classic Hodgkin lymphoma (cHL) has been slower. Early clinical trials have shown promising clinical responses with the use of Epstein-Barr virus-specific cytotoxic T lymphocytes and CD30 CAR T cells in cHL patients, and research on CD19 and CD123 CAR T cells targeting the immunosuppressive tumor microenvironment in cHL is ongoing.
Article
Gastroenterology & Hepatology
Sarah C. Sasson, Stephanie M. Slevin, Vincent T. F. Cheung, Isar Nassiri, Anna Olsson-Brown, Eve Fryer, Ricardo C. Ferreira, Dominik Trzupek, Tarun Gupta, Lulia Al-Hillawi, Mari-lenna Issaias, Alistair Easton, Leticia Campo, Michael E. B. FitzPatrick, Joss Adams, Meenali Chitnis, Andrew Protheroe, Mark Tuthill, Nicholas Coupe, Alison Simmons, Miranda Payne, Mark R. Middleton, Simon P. L. Travis, Benjamin P. Fairfax, Paul Klenerman, Oliver Brain
Summary: Our study demonstrates that CD8(+) tissue resident memory T (T-RM) cells are the main activated T cell subset in ICI colitis. The pattern of gastrointestinal immunopathology in ICI colitis is distinct from ulcerative colitis at both the immune and epithelial-signaling levels. Activation of CD8+ T-RM cells correlates with clinical and endoscopic severity of ICI colitis.
Article
Hematology
Rebecca L. Johnston, Anja Mottok, Fong Chun Chan, Aixiang Jiang, Arjan Diepstra, Lydia Visser, Adele Telenius, Randy D. Gascoyne, Debra L. Friedman, Cindy L. Schwartz, Kara M. Kelly, David W. Scott, Terzah M. Horton, Christian Steidl
Summary: This study investigates the tumor microenvironment biology of pediatric cHL using gene expression profiling and develops a predictive model for pediatric cHL prognosis. It provides a risk-stratification tool for personalized therapy.
Review
Hematology
Antonino Carbone, Annunziata Gloghini, Diego Serraino, Michele Spina, Umberto Tirelli, Emanuela Vaccher
Summary: HL can occur in different host conditions, such as the general population and immunocompromised individuals like PLWH. Current treatment strategies for HIV-associated HL include the combination of cART with anti-neoplastic treatments and high-dose chemotherapy, which have shown to improve long-term survival rates for patients. Immune checkpoint inhibitors are also being explored as a potential treatment option for relapsed and refractory HL cases in the general population.
EXPERT REVIEW OF HEMATOLOGY
(2021)
Review
Gastroenterology & Hepatology
S. L. Rasmussen, H. B. Krarup, K. G. Sunesen, I. S. Pedersen, P. H. Madsen, O. Thorlacius-Ussing
COLORECTAL DISEASE
(2016)
Article
Multidisciplinary Sciences
Simon Ladefoged Rasmussen, Henrik Bygum Krarup, Kare Gotschalck Sunesen, Martin Berg Johansen, Mogens Tornby Stender, Inge Sokilde Pedersen, Poul Henning Madsen, Ole Thorlacius-Ussing
Article
Anatomy & Morphology
Christian Thomsen, Soren Nielsen, Boye S. Nielsen, Sine H. Pedersen, Mogens Vyberg
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2020)
Article
Anatomy & Morphology
Christian Thomsen, Ole Nielsen, Soren Nielsen, Rasmus Roge, Mogens Vyberg
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2020)
Review
Gastroenterology & Hepatology
Linnea Samso Udholm, Simon Ladefoged Rasmussen, Thyge K. Madsboll, Mohammed Omairi, Alaa El-Hussuna
Summary: Urgent bowel resection in patients with Crohn's disease is associated with a higher risk of overall postoperative complications and intraabdominal septic complications. Most studies included in the review had a high risk of bias.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Immunology
Christian Thomsen, Rasmus Roge, Asa Fred, Alkwin Wanders
Summary: Double-stranded RNA (dsRNA) can be detected in most viral infections using immunohistochemistry in formalin-fixed paraffin-embedded (FFPE) tissue. The anti-dsRNA monoclonal antibody clone 9D5 performs better than clone J2, providing a similar staining pattern but a higher signal-to-noise ratio. However, dsRNA detection has low clinical specificity and signals can be reduced by pretreatment with dsRNA-specific RNAse-III.
Article
Anatomy & Morphology
Christian Thomsen, Laura Blok-Husum, Jeanette Baehr Georgsen, Torben Steiniche, Mogens Vyberg
Summary: Recent improvements in the medical treatment of non-small cell lung carcinoma have made the histopathological distinction between adenocarcinomas (ACs) and squamous cell carcinomas (SCCs) increasingly important. One immunohistochemical marker of squamous differentiation is Keratin 5 (K5). This study evaluated the performance of K5 antibodies and found that clone SP27 showed significantly higher analytical sensitivity but lower clinical specificity in the differential diagnosis of SCC versus AC.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2023)
Article
Surgery
L. Schmidt Sorensen, S. Ladefoged Rasmussen, P. C. Calder, M. Nytoft Yilmaz, E. Berg Schmidt, O. Thorlacius-Ussing
Review
Surgery
Saulius Palubinskas, Simon Ladefoged Rasmussen
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2017)