Article
Oncology
Khaled Dibs, Dukagjin M. Blakaj, Rahul N. Prasad, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Evan Thomas, Hyeri Lee, John Grecula, Raju R. Raval, Ehud Mendel, Thomas Scharschmidt, Russell Lonser, Arnab Chakravarti, James B. Elder, Joshua D. Palmer
Summary: Spine SBRT treatment for patients with >= 3 contiguous involved levels is feasible and may offer excellent local control without significant toxicity. Prospective evaluation is warranted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Diana A. Roth O'Brien, Sydney M. Kaye, Phillip J. Poppas, Sean S. Mahase, Anjile An, Paul J. Christos, Benjamin Liechty, David Pisapia, Rohan Ramakrishna, A. G. Wernicke, Jonathan P. S. Knisely, Susan C. Pannullo, Theodore H. Schwartz
Summary: This study evaluated the real-world local recurrence of all brain metastasis patients referred for adjuvant stereotactic radiosurgery (SRS) and identified predictors of SRS timing. The timing of SRS was found to be associated with local recurrence rate and LRFS, with receiving SRS within 4 weeks postoperatively potentially reducing the recurrence rate.
JOURNAL OF NEUROSURGERY
(2021)
Review
Oncology
Marion Tonneau, Raphaelle Mouttet-Audouard, Florence Le Tinier, Xavier Mirabel, David Pasquier
Summary: SBRT appears to be a safe, effective, and rapid treatment option for palliative patients, as shown by a study on five patients treated with SBRT for IMM.
Review
Clinical Neurology
Alfredo Conti, Daniele Starnoni, Juan Barges-Coll, Kyriakos Papadimitriou, Marc Levivier, Constantin Tuleasca
Summary: Radiosurgery is a safe and effective treatment for spinal vertebral hemangiomas. It provides significant pain relief for patients and does not result in progressive disease. However, higher radiation doses may cause damage to surrounding tissues.
WORLD NEUROSURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongye Chen, Siyuan Qin, Weili Zhao, Qizheng Wang, Ke Liu, Peijin Xin, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: This study aimed to develop response prediction models for patients with spinal metastases undergoing stereotactic body radiotherapy (SBRT) by extracting radiomics features from MRI using machine learning algorithms. The results showed that the MRI-based radiomics models have valuable predictive capability for treatment outcomes in these patients.
INSIGHTS INTO IMAGING
(2023)
Article
Clinical Neurology
Dukagjin M. Blakaj, Joshua D. Palmer, Khaled Dibs, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Miki Katzir, Vedat O. Yildiz, John Grecula, Andrea Arnett, Raju Raval, Thomas Scharschmidt, James B. Elder, Russell Lonser, Arnab Chakravarti, Ehud Mendel
Summary: Factors associated with local control and progression-free survival for patients receiving postoperative stereotactic spine radiosurgery included time from surgery to radiosurgery, radiotherapy dose, and preoperative embolization.
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Clinical Neurology
Pejman Jabehdar Maralani, Chia-Lin Tseng, Hamidreza Baharjoo, Erin Wong, Anish Kapadia, Archya Dasgupta, Peter Howard, Aimee K. M. Chan, Eshetu G. Atenafu, Hua Lu, Pascal Tyrrell, Sunit Das, Seyedmehdi Payabvash, Jay Detsky, Zain Husain, Sten Myrehaug, Hany Soliman, Hanbo Chen, Chris Heyn, Sean Symons, Arjun Sahgal
Summary: This study aimed to determine the minimum detectable difference in GTV based on MRI and found that larger volume changes were required before local failure could be determined for small tumors compared to medium/large tumors.
Article
Oncology
Roman O. Kowalchuk, Benjamin A. Johnson-Tesch, Joseph T. Marion, Trey C. Mullikin, William S. Harmsen, Peter S. Rose, Brittany L. Siontis, Dong Kun Kim, Brian A. Costello, Jonathan M. Morris, Robert W. Gao, Satomi Shiraishi, John J. Lucido, Terence T. Sio, Daniel M. Trifiletti, Kenneth R. Olivier, Dawn Owen, Bradley J. Stish, Mark R. Waddle, Nadia N. Laack, Sean S. Park, Paul D. Brown, Kenneth W. Merrell
Summary: This study aimed to develop and evaluate a risk stratification model for vertebral compression fracture (VCF) after Stereotactic Body Radiation Therapy (SBRT). By studying a cohort of 331 patients, several variables associated with high risk of VCF were identified, and a multivariable Cox model was proposed to predict the risk of VCF accurately.
Article
Oncology
Khaled Dibs, Joshua D. D. Palmer, Rahul N. N. Prasad, Alexander Olausson, Eric C. C. Bourekas, Daniel Boulter, Ahmet S. S. Ayan, Eric Cochran, William S. S. Marras, Prasath Mageswaran, Evan Thomas, John Grecula, Michael Guiou, Soheil Soghrati, Esmerina Tili, Raju R. R. Raval, Ehud Mendel, Thomas Scharschmidt, James B. B. Elder, Russell Lonser, Arnab Chakravarti, Dukagjin M. M. Blakaj
Summary: Circumferential spine SBRT is feasible and may offer excellent local control without significant toxicity for patients with circumferential disease. Prospective evaluation of this approach is warranted.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Felix Ehret, David Kaul, Volker Budach, Laura-Nanna Lohkamp
Summary: This systematic review summarizes the current experience and evidence for robotic radiosurgery (RRS) and robotic stereotactic radiotherapy (RSRT) in pediatric neuro-oncology. The results indicate that both treatment modalities are infrequently used and primarily employed in specific situations, with encouraging treatment outcomes but a lack of high-quality studies. Prospective studies are needed to determine the actual utility of RRS and RSRT in pediatric neuro-oncology.
Article
Clinical Neurology
Daniel Moore-Palhares, Arjun Sahgal, K. Liang Zeng, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Mark Ruschin, Eshetu G. Atenafu, Jeff Wilson, Jeremie Larouche, Leodante da Costa, Pejman Jabehdar Maralani, Hany Soliman
Summary: This study reports the outcomes of a novel fractionation scheme, 30 Gy in 4 fractions, for the treatment of spinal metastases. The results show that this approach is safe and effective, especially for patients with a clinical target volume (CTV) volume of ≥72 cc.
Article
Clinical Neurology
Yongye Chen, Enlong Zhang, Qizheng Wang, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: In this study, DCE-MRI was used to evaluate the early efficacy of CyberKnife stereotactic radiosurgery in patients with symptomatic vertebral hemangioma (SVH). The study found that parameters K-trans and K-ep changed significantly after treatment, indicating the potential value of DCE-MRI in assessing treatment efficacy.
EUROPEAN SPINE JOURNAL
(2021)
Article
Oncology
Marcin Miszczyk, Mateusz Sajdok, Jacek Bednarek, Tomasz Latusek, Wojciech Wojakowski, Bartlomiej Tomasik, Krystian Wita, Tomasz Jadczyk, Radoslaw Kurzelowski, Anna Drzewiecka, Magdalena Cybulska, Rafal Gardas, Grzegorz Jarosinski, Lukasz Dolla, Aleksandra Grzadziel, Kamil Zub, Adam Bekman, Konrad Kaminiow, Anna Kozub, Krzysztof S. Golba, Slawomir Blamek
Summary: This study evaluated the safety and efficacy of stereo-tactic arrhythmia radioablation (STAR) in patients with ventricular tachycardia (VT). The results showed that STAR is a safe and effective treatment, reducing VT burden. However, long-term outcomes still need to be evaluated.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Clinical Neurology
Palak P. Patel, Edward P. Esposito, Jiafeng Zhu, Xuguang Chen, Majid Khan, Lawrence Kleinberg, Daniel Lubelski, Nicholas Theodore, Sheng-fu Larry Lo, Sang Hun Lee, Khaled Kebaish, Ali Bydon, Kristin J. Redmond
Summary: This study examines the association between antiresorptive use surrounding spinal SBRT and vertebral compression fracture (VCF) incidence, and the results suggest that initiating antiresorptive agents before SBRT may reduce the risk of treatment-induced VCF.
GLOBAL SPINE JOURNAL
(2023)