期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 276, 期 -, 页码 38-45出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2016.11.009
关键词
Magnetoencephalography; Head localization; Spatial resolution; MRI-MEG Co-registration; Head movement minimization; Head-cast; 3D printing
资金
- Wellcome Trust
- Medical Research Council and Engineering and Physical Sciences Research Council [MR/K6010/86010/1]
- Medical Research Council UKMEG Partnership grant [MR/K005464/1]
- BBSRC research grant [BB/M009645/1]
- Medical Research Council New Investigator Grant [MR/M006301/1]
- Wellcome Trust [091593/Z/10/Z]
- European Research Council under the European Union's Seventh Framework Programme (FP7)/ERC grant [616905]
- Biotechnology and Biological Sciences Research Council [BB/M009645/1] Funding Source: researchfish
- Medical Research Council [MR/M006301/1] Funding Source: researchfish
- BBSRC [BB/M009645/1] Funding Source: UKRI
- MRC [MR/M006301/1] Funding Source: UKRI
Background: In combination with magnetoencephalographic (MEG) data, accurate knowledge of the brain's structure and location provide a principled way of reconstructing neural activity with high temporal resolution. However, measuring the brain's location is compromised by head movement during scanning, and by fiducial-based co-registration with magnetic resonance imaging (MRI) data. The uncertainty from these two factors introduces errors into the forward model and limit the spatial resolution of the data. New method: We present a method for stabilizing and reliably repositioning the head during scanning, and for co-registering MRI and MEG data with low error. Results: Using this new flexible and comfortable subject-specific head-cast prototype, we find within session movements of<0.25 mm and between-session repositioning errors around 1 mm. Comparison with existing method(s): This method is an improvement over existing methods for stabilizing the head or correcting for location shifts on-or off-line, which still introduce approximately 5 mm of uncertainty at best (Adjamian et al., 2004; Stolle et al., 2013; Whalen et al., 2008). Further, the head-cast design presented here is more comfortable, safer, and easier to use than the earlier 3D printed prototype, and give slightly lower co-registration errors (Troebinger et al., 2014b). Conclusions: We provide an empirical example of how these head-casts impact on source level reproducibility. Employment of the individual flexible head-casts for MEG recordings provide a reliable method of safely stabilizing the head during MEG recordings, and for co-registering MRI anatomical images to MEG functional data. (C) 2016 The Author(s). Published by Elsevier B.V.
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