期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 30, 页码 7164-7176出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0245-17.2017
关键词
emotion; sleep; wakefulness
资金
- Merck Investigator Studies Program, a KAKENHI [54843, JP15H01425]
- Japan Society for the Promotion of Science [JP 15H03122]
- KAKENHI [JP 15K12768, 16H06401]
- Merck Sharp and Dohme Corp
- Grants-in-Aid for Scientific Research [15H03122, 16H06400, 16H06401] Funding Source: KAKEN
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether the extended amygdala plays a role in sleep-wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus of the stria terminalis (GABA(BNST) neurons). Acute optogenetic excitation of these cells during nonrapid eye movement (NREM) sleep resulted in an immediate state transition to wakefulness, whereas stimulation during REM sleep showed no effect on sleep-wakefulness states in male mice. An anterograde tracing study suggested GABA(BNST) neurons send axonal projections to several brain regions implicated in arousal, including the preoptic area, lateral hypothalamus, periaqueductal gray, deep mesencephalic nucleus, and parabrachial nucleus. A dual orexin receptor antagonist, DORA-22, did not affect the optogenetic transition from NREM sleep to wakefulness. Chemogenetic excitation of GABA(BNST) neurons evoked a sustained wakefulness state, but this arousal effect was markedly attenuated by DORA-22. These observations suggest that GABA(BNST) neurons play an important role in transition from NREM sleep to wakefulness without the function of orexin neurons, but prolonged excitation of these cells mobilizes the orexin system to sustain wakefulness.
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