期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 81, 期 4, 页码 264-268出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2015.01.003
关键词
Multidrug-resistant bacteria; Prevalence; MLST; Enterobacter cloacae
资金
- INSERM, France
- University of Fribourg, Switzerland
- European Community [FP7/HEALTH-F3-2011-282512, FP7/HEALTH-F3-2001-278232]
A multilocus sequence typing (MIST) scheme including 7 housekeeping genes was used to evaluate whether the current spread of multidrug-resistant Enterobacter cloacae isolates worldwide might be associated to specific successful clones. Fifty E. cloacae clinical isolates of worldwide origin, with various beta-lactamase content, and recovered at different periods of time were studied. Forty-four sequence types were identified, highlighting a high clonal diversity with 3 main lineages. This study revealed that a precise identification of the isolates by sequencing of the chromosomal ampC gene of E. cloacae would provide a significant added value to improve the reliability of the MLST scheme. (C) 2015 Elsevier Inc. All rights reserved.
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