期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 50, 页码 12153-12166出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0588-17.2017
关键词
cerebellum; combinatorial expansion; combinatorics; granule cell; motor learning; Purkinje
资金
- National Institutes of Health [R01 NS084996-01]
- Klingenstein Foundation
- McKnight Foundation
- Rocky Mountain Neurological Disorders Core Grant [P30NS048154]
- National Institutes of Health CTSI [UL1 RR025780]
Combinatorial expansion by the cerebellar granule cell layer (GCL) is fundamental to theories of cerebellar contributions to motor control and learning. Granule cells (GrCs) sample approximately four mossy fiber inputs and are thought to form a combinatorial code useful for pattern separation and learning. We constructed a spatially realistic model of the cerebellar GCL and examined how GCL architecture contributes to GrC combinatorial diversity. We found that GrC combinatorial diversity saturates quickly as mossy fiber input diversity increases, and that this saturation is in part a consequence of short dendrites, which limit access to diverse inputs and favor dense sampling of local inputs. This local sampling also produced GrCs that were combinatorially redundant, even when input diversity was extremely high. In addition, we found that mossy fiber clustering, which is a common anatomical pattern, also led to increased redundancy of GrC input combinations. We related this redundancy to hypothesized roles of temporal expansion of GrC information encoding in service of learned timing, and we show that GCL architecture produces GrC populations that support both temporal and combinatorial expansion. Finally, we used novel anatomical measurements from mice of either sex to inform modeling of sparse and filopodia-bearing mossy fibers, finding that these circuit features uniquely contribute to enhancing GrC diversification and redundancy. Our results complement information theoretic studies of granule layer structure and provide insight into the contributions of granule layer anatomical features to afferent mixing.
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