期刊
JOURNAL OF NEUROSCIENCE
卷 37, 期 34, 页码 8062-8076出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3490-16.2017
关键词
entorhinal cortex; grid cell; hippocampus; pattern completion; place cell; remapping
资金
- Brazilian Agency CAPES through the Science Without Borders program
- Brazilian Agency CNPq
Place cells in the hippocampus and grid cells in the medial entorhinal cortex have different codes for space. However, howone code relates to the other is ill understood. Based on the anatomy of the entorhinal-hippocampal circuitry, we constructed a model of place and grid cells organized in a loop to investigate their mutual influence in the establishment of their codes for space. Using computer simulations, we first replicated experiments in rats that measured place and grid cell activity in different environments, and then assessed which features of the model account for different phenomena observed in neurophysiological data, such as pattern completion and pattern separation, global and rate remapping of place cells, and realignment of grid cells. We found that (1) the interaction between grid and place cells converges quickly; (2) the spatial code of place cells does not require, but is altered by, grid cell input; (3) plasticity in sensory inputs to place cells is key for pattern completion but not pattern separation; (4) grid realignment can be explained in terms of place cell remapping as opposed to the other way around; (5) the switch between global and rate remapping is self-organized; and (6) grid cell input to place cells helps stabilize their code under noisy and/or inconsistent sensory input. We conclude that the hippocampus-entorhinal circuit uses the mutual interaction of place and grid cells to encode the surrounding environment and propose a theory on how such interdependence underlies the formation and use of the cognitive map.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据