期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 2, 页码 347-362出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1279-17.2017
关键词
corticocortical; corticostriatal; corticotectal; electron microscopy; interneuron; pulvinocortical
资金
- National Eye Institute [R01EY024173]
- Kentucky Science and Engineering Foundation
- NATIONAL EYE INSTITUTE [R01EY012716, R01EY024173] Funding Source: NIH RePORTER
The pulvinar nucleus is a large thalamic structure involved in the integration of visual and motor signals. The pulvinar forms extensive connections with striate and extrastriate cortical areas, but the impact of these connections on cortical circuits has not previously been directly tested. Using a variety of anatomical, optogenetic, and in vitro physiological techniques in male and female mice, we show that pulvinocortical terminals are densely distributed in the extrastriate cortex where they form synaptic connections with spines and small-diameter dendrites. Optogenetic activation of these synapses in vitro evoked large excitatory postsynaptic responses in the majority of pyramidal cells, spiny stellate cells, and interneurons within the extrastriate cortex. However, specificity in pulvinar targeting was revealed when recordings were targeted to projection neuron subtypes. The neurons most responsive to pulvinar input were those that project to the striatum and amygdala (76% responsive) or V1 (55%), whereas neurons that project to the superior colliculus were rarely responsive (6%). Because the pulvinar also projects directly to the striatum and amygdala, these results establish the pulvinar nucleus as a hub linking the visual cortex with subcortical regions involved in the initiation and control of movement. Wesuggest that these circuits may be particularly important for coordinating body movements and visual perception.
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