期刊
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
卷 29, 期 2, 页码 142-147出版社
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.16040062
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资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Norte (FAPERN, Brazil)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
An association between Parkinson's disease (PD) and brain-derived neurotrophic factor (BDNF) was suggested by several studies, with contradictory results. BDNF is necessary for the survival of dopaminergic neurons in substantia nigra. Val66Met is a common polymorphism of the BDNF gene that affects cognitive and motor processes. The authors studied 104 Brazilian patients with PD and 96 control participants. The G/G genotype was significantly associated with depression and anxiety symptoms and development of PD. This is the first study that associates this genotype with PD.
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