Low intrathecal antibody production despite high seroprevalence of Epstein–Barr virus in multiple sclerosis: a review of the literature

Untreated relapsing remitting multiple sclerosis patients show antibody production against latent Epstein Barr Virus (EBV) antigens mainly in the periphery and innate immune IL-8 responses preferentially in the CNS

(2017) Sofia Sisay et al.   JOURNAL OF NEUROIMMUNOLOGY

The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature

(2016) S. Jarius et al.   JOURNAL OF NEUROLOGY

Antibody producing B lineage cells invade the central nervous system predominantly at the time of and triggered by acute Epstein–Barr virus infection: A hypothesis on the origin of intrathecal immunoglobulin synthesis in multiple sclerosis

(2016) Carolin Otto et al.   MEDICAL HYPOTHESES

Epidemiology of Multiple Sclerosis: From Risk Factors to Prevention—An Update

(2016) Kassandra Munger et al.   SEMINARS IN NEUROLOGY

Association of serum Epstein–Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis

(2015) Catherina Pfuhl et al.   JOURNAL OF NEUROIMMUNOLOGY

Antibody patterns vary arbitrarily between cerebrospinal fluid and aqueous humor of the individual multiple sclerosis patient: Specificity-independent pathological B cell function

(2015) Hansotto Reiber et al.   JOURNAL OF NEUROIMMUNOLOGY

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

(2015) Lazaros Belbasis et al.   LANCET NEUROLOGY

Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination

(2015) Naila Makhani et al.   Multiple Sclerosis Journal

Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination

(2015) Naila Makhani et al.   Multiple Sclerosis Journal

Epstein-Barr virus-specific intrathecal oligoclonal IgG production in relapsing-remitting multiple sclerosis is limited to a subset of patients and is composed of low-affinity antibodies

(2014) Massimiliano Castellazzi et al.   Journal of Neuroinflammation

Systematic Review and Meta-Analysis of the Sero-Epidemiological Association between Epstein Barr Virus and Multiple Sclerosis

(2013) Yahya H. Almohmeed et al.   PLoS One

Behavioral, Virologic, and Immunologic Factors Associated With Acquisition and Severity of Primary Epstein–Barr Virus Infection in University Students

(2012) Henry H. Balfour et al.   JOURNAL OF INFECTIOUS DISEASES

The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis

(2012) J. Pakpoor et al.   Multiple Sclerosis Journal

The initiation and prevention of multiple sclerosis

(2012) Alberto Ascherio et al.   Nature Reviews Neurology

Measles IgG Antibody Index Correlates with T2 Lesion Load on MRI in Patients with Early Multiple Sclerosis

(2012) Berit Rosche et al.   PLoS One

Seroprevalence of Measles-, Mumps- and Rubella-Specific IgG Antibodies in German Children and Adolescents and Predictors for Seronegativity

(2012) Christina Poethko-Müller et al.   PLoS One

Low intrathecal immune response of anti–EBNA-1 antibodies and EBV DNA from multiple sclerosis patients

(2011) Enrique Villegas et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Anti-Epstein–Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel

(2011) KL Munger et al.   Multiple Sclerosis Journal

Intrathecal EBV antibodies are part of the polyspecific immune response in multiple sclerosis

(2011) C. Otto et al.   NEUROLOGY

Common viruses associated with lower pediatric multiple sclerosis risk

(2011) E. Waubant et al.   NEUROLOGY

Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis

(2010) Massimiliano Castellazzi et al.   Multiple Sclerosis Journal

Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis

(2010) S. A. Sargsyan et al.   NEUROLOGY

An Updated Meta-Analysis of Risk of Multiple Sclerosis following Infectious Mononucleosis

(2010) Adam E. Handel et al.   PLoS One

Intrathecal antibody production against Epstein-Barr and other neurotropic viruses in pediatric and adult onset multiple sclerosis

(2009) Daniela Pohl et al.   JOURNAL OF NEUROLOGY

Paediatric and adult multiple sclerosis: age-related differences and time course of the neuroimmunological response in cerebrospinal fluid

(2009) H. Reiber et al.   Multiple Sclerosis Journal

The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis

(2009) Douglas S. Goodin   PLoS One

IgG Antibodies against Measles, Rubella, and Varicella Zoster Virus Predict Conversion to Multiple Sclerosis in Clinically Isolated Syndrome

(2009) Johannes Brettschneider et al.   PLoS One

Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica

(2008) S Jarius et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Common infectious agents in multiple sclerosis: a case—control study in children

(2007) Bernd Krone et al.   Multiple Sclerosis Journal