Article
Pharmacology & Pharmacy
Lucia Gozzo, Giovanni Luca Romano, Serena Brancati, Laura Longo, Daniela Cristina Vitale, Filippo Drago
Summary: According to European regulation, new drugs for neurodegenerative diseases, autoimmune and immune dysfunctions must be approved by EMA before being marketed. Each country is responsible for national market access, based on assessment by HTA bodies. This study compares HTA recommendations issued by France, Germany, and Italy for MS drugs following EMA approval. Out of the 11 authorized MS drugs in Europe, there was no agreement on their therapeutic value, indicating the need for better efficacy and safety profiles.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Weipeng Wei, Denglei Ma, Lin Li, Lan Zhang
Summary: Multiple sclerosis is an autoimmune and chronic inflammatory demyelinating disease of the central nervous system, with no complete cure currently available but drugs that can slow down its progression. Traditional therapies mainly focus on disease-modifying drugs to control severity, while new drugs and treatment strategies are being developed.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Martin L. Dalefield, Brittany Scouller, Rabia Bibi, Bronwyn M. Kivell
Summary: Kappa-opioid receptors have wide-ranging effects on various physiological processes and hold therapeutic potential for pain, pruritis, and other diseases. However, adverse effects limit their clinical use, highlighting the need for further development.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Eleonora Cocco, Paola Fadda
Summary: Multiple sclerosis is a complex disorder with a wide range of symptoms, categorized as visible and invisible. Fatigue is a common symptom in MS patients that significantly impacts daily living and quality of life, and it does not improve with rest.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Engineering, Biomedical
Xiangdong Xue, Haijing Qu, Ruonan Bo, Dalin Zhang, Zheng Zhu, Bai Xiang, Longmeng Li, Marina Ricci, Chong-Xian Pan, Tzu-Yin Lin, Yuanpei Li
Summary: We developed a size/charge dually transformable nanoplatform (PDR NP) with multiple therapeutic and immunostimulatory properties to effectively treat advanced cancers. The PDR NPs exhibit three different therapeutic modalities (chemotherapy, phototherapy, and immunotherapy) and can effectively treat primary and distant tumors, as well as reduce recurrent tumors. The immunotherapy is activated by three major pathways, effectively suppressing tumor development in combination with an immune checkpoint inhibitor. The size and charge responsive transformability of PDR NPs in the tumor microenvironment allows efficient delivery of payloads into tumor cells.
Article
Clinical Neurology
Ran Zhou, Qiuming Zeng, Huan Yang, Yan Xu, Guojun Tan, Hongbo Liu, Lihua Wang, Hongyu Zhou, Meini Zhang, Jinzhou Feng, Tao Jin, Xinghu Zhang, Jiawei Wang, Xu Zhang, Feng Gao, Chunsheng Yang, Bitao Bu, Chunyang Li, Min Zhang, Huiqing Dong, Aiyu Lin, Weibin Liu, Lei Wu, Manxia Wang, Yulan Tang, Honghao Wang, Youming Long, Zhe Wang, Weihong Zheng
Summary: The study found that highly educated patients with frequent relapses were more willing to receive treatment, while patients with more understanding of the disease opted to be treated. Younger patients, those with severe disease course, and those with more symptoms were more likely to choose treatment. A higher proportion of women chose to be treated with DMTs than with other immunotherapies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Alyssa A. Toorop, Zoe Y. G. J. van Lierop, Liza M. Y. Gelissen, Elske Hoitsma, Esther M. P. E. Zeinstra, Luuk C. van Rooij, Caspar E. P. van Munster, Anke Vennegoor, Jop P. Mostert, Beatrijs H. A. Wokke, Nynke F. Kalkers, Erwin L. J. Hoogervorst, Jeroen J. J. van Eijk, Christiaan M. Roosendaal, Jolijn J. Kragt, Marijke Eurelings, Jessie van Genugten, Jessica Nielsen, Lgf Sinnige, Mark E. Kloosterziel, Edo P. J. Arnoldus, Gert W. van Dijk, Willem H. Bouvy, Mark H. J. Wessels, Lynn Boonkamp, Eva M. M. Strijbis, Bob W. van Oosten, Brigit A. De Jong, Birgit Lissenberg-Witte, Frederik Barkhof, Bastiaan Moraal, Charlotte E. Teunissen, Theo Rispens, Bernard M. J. Uitdehaag, Joep Killestein, Zoe L. E. van Kempen
Summary: Personalized extended interval dosing of natalizumab effectively controls disease activity in multiple sclerosis and can safely extend treatment intervals through therapeutic drug monitoring.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Medicine, Research & Experimental
Behnam Hashemi, Maryam Abdollahi, Sanaz Abbaspour-Aghdam, Ali Hazrati, Kosar Malekpour, Shahla Meshgi, Hossein Samadi Kafil, Farhood Ghazi, Mehdi Yousefi, Leila Roshangar, Majid Ahmadi
Summary: Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system and results in nerve demyelination. The exact cause of MS is unknown, but regulating the immune system and inhibiting inflammatory pathways may have positive effects on disease control and improvement. Studies have shown that probiotics can modulate the gut microbiome, thus impacting the immune system and inflammatory responses in MS patients. The findings indicate that probiotics have a beneficial effect on the recovery of both human and animal MS patients. This review article explores the impact of probiotics on immune cells and inflammatory cytokines, highlighting their potential therapeutic mechanisms and role in disease management and control.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Jiaqi Yao, Xinchan Jiang, Joyce H. S. You
Summary: The study evaluated the cost-effectiveness of proactive versus reactive therapeutic drug monitoring of adalimumab in pediatric patients with Crohn's disease from the perspective of the US health-care provider. Results showed that proactive TDM led to higher quality-adjusted life-years at a lower cost compared to reactive TDM, with ADL drug cost being the most influential factor.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Emilie Audouard, Fanny Michel, Vanessa Pierroz, Taeuk Kim, Lisa Rousselot, Beatrix Gillet-Legrand, Gaelle Dufayet-Chauffaut, Peter Buchmann, Michael Florea, Alexander Khel, Kamilya Altynbekova, Claudia Delgaldo, Encarna Escudero, Alejandra Ben Aissa Soler, Nathalie Cartier, Francoise Piguet, Marc Folcher
Summary: This study presents a wireless powered optogenetic cell-based implant for subcutaneously delivering therapeutic proteins. Utilizing immortalized immune human stem cells for controlled interferon-13 release, a bioelectronic cell-based implant was established. Integration of wireless optoelectronic devices and industrial flexible high-performance equipment was demonstrated.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Clinical Neurology
Maria Cellerino, Giacomo Boffa, Caterina Lapucci, Francesco Tazza, Elvira Sbragia, Elisabetta Mancuso, Nicolo Bruschi, Simona Minguzzi, Federico Ivaldi, Ilaria Poire, Alice Laroni, Gianluigi Mancardi, Elisabetta Capello, Antonio Uccelli, Giovanni Novi, Matilde Inglese
Summary: The study found that ocrelizumab is an effective and safe treatment for patients with RRMS and PMS, with better outcomes observed in treatment-naive patients and those with lower baseline disability levels. Depletion of CD8 + cells may be a key factor in the early therapeutic effects of ocrelizumab.
Article
Immunology
Xinyue Yin, Xinming Rang, Xiangxiang Hong, Yinglian Zhou, Chaohan Xu, Jin Fu
Summary: In this study, target genes and target pathways for drug repositioning in multiple sclerosis (MS) were identified based on transcriptomic changes in MS immune cells. The study found that targeting both the PI3K-Akt signaling pathway and Chemokine signaling pathway, or using tyrosine kinase inhibitors may be potential therapies for the treatment of MS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
Emma Campbell, Hope Adamson, Declan Kohl, Christian Tiede, Christoph Walti, Darren C. Tomlinson, Lars J. C. Jeuken
Summary: The study demonstrates a method using an enzyme switch sensor platform for rapid and sensitive quantification of two monoclonal antibody therapies. This method successfully monitored the two therapies within the therapeutic range in human serum.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Clinical Neurology
Jianfeng Lin, Jiawei Zhou, Yan Xu
Summary: Lin et al. use Mendelian randomization analysis to identify potential drug targets for multiple sclerosis. They find that genetically determined levels of certain plasma and CSF proteins are associated with multiple sclerosis risk. These findings suggest promising drug targets for multiple sclerosis prevention.
Article
Biochemistry & Molecular Biology
Pasquale Picone, Domenico Nuzzo
Summary: In recent years, studies have shown that mitochondrial aberration plays a crucial role in mediating axonal degeneration in Multiple Sclerosis (MS), along with inflammation and demyelination. This has led to the recognition of mitochondria as a potential therapeutic target for MS. Mitochondrial transplantation has emerged as a new approach for treating various diseases, including neurodegenerative diseases. In this hypothesis, the authors propose mitochondrial transplantation as a new, potentially applicable strategy to counteract axonal degeneration in multiple sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ryan D. Schubert, Yang Hu, Gaurav Kumar, Spencer Szeto, Peter Abraham, Johannes Winderl, Joel M. Guthridge, Gabriel Pardo, Jeffrey Dunn, Lawrence Steinman, Robert C. Axtell
JOURNAL OF IMMUNOLOGY
(2015)
Correction
Clinical Neurology
Gabriel Pardo, David E. Jones
JOURNAL OF NEUROLOGY
(2017)
Review
Clinical Neurology
Farhat Husain, Gabriel Pardo, Meheroz Rabadi
CURRENT TREATMENT OPTIONS IN NEUROLOGY
(2018)
Article
Clinical Neurology
Raja Kapoor, Pei-Ran Ho, Nolan Campbell, Ih Chang, Aaron Deykin, Fiona Forrestal, Nisha Lucas, Bei Yu, Douglas L. Arnold, Mark Freedman, Myia D. Goldman, Hans-Peter Hartung, Eva Kubala Havrdova, Douglas Jeffery, Aaron Miller, Finn Sellebjerg, Diego Cadavid, Dan Mikol, Deborah Steiner
Article
Clinical Neurology
Michael Kaufman, Gabriel Pardo, Howard Rossman, Marianne T. Sweetser, Fiona Forrestal, Petra Duda
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2014)
Article
Clinical Neurology
Cecilie Fjeldstad, Anette S. Fjeldstad, Joseph P. Weir, Gabriel Pardo
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2014)
Article
Pharmacology & Pharmacy
Eduardo D. S. Freitas, Christine Frederiksen, Ryan M. Miller, Aaron Heishman, Mark Anderson, Gabriel Pardo, Cecilie Fjeldstad, Debra A. Bemben, Michael G. Bemben
Article
Clinical Neurology
Christopher M. Perrone, Robert P. Lisak, Ethan Meltzer, Peter Sguigna, Etsegenet Tizazu, Dina Jacobs, Esther Melamed, Ashlea Lucas, Leorah Freeman, Gabriel Pardo, Andrew Goodman, Edward J. Fox, Kathleen Costello, Matthew S. Parsons, Scott S. Zamvil, Elliot M. Frohman, Teresa C. Frohman
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2019)
Article
Immunology
Neelakshi R. Jog, Micah T. McClain, Latisha D. Heinlen, Timothy Gross, Rheal Towner, Joel M. Guthridge, Robert C. Axtell, Gabriel Pardo, John B. Harley, Judith A. James
JOURNAL OF AUTOIMMUNITY
(2020)
Article
Environmental Sciences
John W. Farrell, Debra A. Bemben, Christopher D. Black, Daniel J. Larson, Gabriel Pardo, Cecilie Fjeldstad-Pardo, Rebecca D. Larson
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Review
Clinical Neurology
Gabriel Pardo, Samantha Coates, Darin T. Okuda
Summary: Various instruments have been developed to assess disease stability or progression in individuals with multiple sclerosis, providing clinicians with valuable tools to optimize therapy. Technological advancements, such as wearable sensors, offer new opportunities to better understand changes in MS-related symptoms and impairment. Continued research and development have significantly improved the management and evaluation of MS in recent decades.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Bobbette J. Miller, Thubi H. A. Kolobe, Rebecca D. Larson, Brian A. Pribble, Gabriel Pardo, Shirley A. James
Summary: This study investigated the effects of a combination treatment of intermuscular electrical stimulation and functional electrical stimulation on gait, spasticity, fatigue, and muscle strength in individuals with multiple sclerosis (MS). The results showed that participants demonstrated improvements in gait speed, endurance, and a decrease in spasticity after the treatment. The combination intervention also increased toe taps and heel raises without increasing fatigue.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2022)