Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner

High-Mobility Group Box 1 (HMGB1) Is Elevated Systemically in Persons with Acute or Chronic Traumatic Spinal Cord Injury

(2017) Angelos Papatheodorou et al.   JOURNAL OF NEUROTRAUMA

Probenecid protects against oxygen–glucose deprivation injury in primary astrocytes by regulating inflammasome activity

(2016) Zhihong Jian et al.   BRAIN RESEARCH

Downregulation of Aquaporin-4 Protects Brain Against Hypoxia Ischemia via Anti-inflammatory Mechanism

(2016) Sujuan Liu et al.   MOLECULAR NEUROBIOLOGY

High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury

(2016) Athanasios Didangelos et al.   Scientific Reports

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury

(2016) Nasya M. Sturdivant et al.   Scientific Reports

LPS-Primed Release of HMGB-1 from Cortical Astrocytes is Modulated Through PI3K/AKT Pathway

(2015) Ze-Feng Xie et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway

(2015) Xi Li et al.   INFLAMMATION

TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis

(2015) GANG LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Relative Contribution of Edema and Hemorrhage to Raised Intrathecal Pressure after Traumatic Spinal Cord Injury

(2015) Anna V. Leonard et al.   JOURNAL OF NEUROTRAUMA

Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the JAK/STAT signaling pathway

(2014) Jianing Zu et al.   ACTA HISTOCHEMICA

Involvement of Aquaporin 4 in Astrocyte Function and Neuropsychiatric Disorders

(2014) Ming Xiao et al.   CNS Neuroscience & Therapeutics

High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem/progenitor cells

(2014) MAN LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Immunolocalization of Water Channel Proteins AQP1 and AQP4 in Rat Spinal Cord

(2014) Michal K. Oklinski et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Activation of NF-κB Mediates Astrocyte Swelling and Brain Edema in Traumatic Brain Injury

(2014) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROTRAUMA

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

(2014) Hongbin Ni et al.   JOURNAL OF SPINAL CORD MEDICINE

Oxygen Glucose Deprivation/Reperfusion Astrocytes Promotes Primary Neural Stem/Progenitor Cell Proliferation by Releasing High-Mobility Group Box 1

(2014) Man Li et al.   NEUROCHEMICAL RESEARCH

High-mobility group box 1 up-regulates aquaporin 4 expression via microglia–astrocyte interaction

(2014) Masatoshi Ohnishi et al.   NEUROCHEMISTRY INTERNATIONAL

Myelotomy reduces spinal cord edema and inhibits aquaporin-4 and aquaporin-9 expression in rats with spinal cord injury

(2014) A-M Hu et al.   SPINAL CORD

Drowning stars: reassessing the role of astrocytes in brain edema

(2014) Alexander S. Thrane et al.   TRENDS IN NEUROSCIENCES

The Role of High Mobility Group Box 1 in Innate Immunity

(2014) Shin-Ae Lee et al.   YONSEI MEDICAL JOURNAL

Precipitants of hepatic encephalopathy induce rapid astrocyte swelling in an oxidative stress dependent manner

(2013) Vera Lachmann et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats

(2013) Rui Ge et al.   BRAIN RESEARCH

High mobility group box protein-1 promotes cerebral edema after traumatic brain injury via activation of toll-like receptor 4

(2013) Melissa D. Laird et al.   GLIA

Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy

(2013) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Aquaporin-4 Expression in Post-Traumatic Syringomyelia

(2013) Sarah J. Hemley et al.   JOURNAL OF NEUROTRAUMA

Knocking Down HMGB1 Using Dendrimer-Delivered siRNA Unveils Its Key Role in NMDA-Induced Autophagy in Rat Cortical Neurons

(2013) María D. Pérez-Carrión et al.   PHARMACEUTICAL RESEARCH

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

Hyperbaric Oxygen Alleviates Experimental (Spinal Cord) Injury by Downregulating HMGB1/NF-κB Expression

(2013) Jing Yang et al.   SPINE

High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter

(2012) Kazuhide Hayakawa et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β

(2012) Emanuele Zurolo et al.   Journal of Neuroinflammation

Chronic-Pain-Associated Astrocytic Reaction in the Spinal Cord Dorsal Horn of Human Immunodeficiency Virus-Infected Patients

(2012) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

HMGB1 in Development and Diseases of the Central Nervous System

(2012) Ping Fang et al.   MOLECULAR NEUROBIOLOGY

Protective effects of erythropoietin on astrocytic swelling after oxygen–glucose deprivation and reoxygenation: Mediation through AQP4 expression and MAPK pathway

(2012) Zhaohua Tang et al.   NEUROPHARMACOLOGY

Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy

(2012) A.R. Jayakumar et al.   NEUROSCIENCE

Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1

(2011) Gu Gong et al.   ACTA PHARMACOLOGICA SINICA

Toll-like receptors in cerebral ischemic inflammatory injury

(2011) Yan-Chun Wang et al.   Journal of Neuroinflammation

Aquaporin-4 Expression in Cultured Astrocytes after Fluid Percussion Injury

(2011) Kakulavarapu V. Rama Rao et al.   JOURNAL OF NEUROTRAUMA

High-Mobility Group Box-1 and Its Receptors Contribute to Proinflammatory Response in the Acute Phase of Spinal Cord Injury in Rats

(2011) Ke-Bing Chen et al.   SPINE

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

The effect of aminoguanidine on compression spinal cord injury in rats

(2010) Zhong-kai Fan et al.   BRAIN RESEARCH

Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes

(2010) Kakulavarapu V Rama Rao et al.   Journal of Neuroinflammation

Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-κB expression

(2010) Lina Wang et al.   NEUROSCIENCE LETTERS

High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia

(2010) Jianhua Qiu et al.   STROKE

Aquaporin-4 in brain and spinal cord oedema

(2009) S. Saadoun et al.   NEUROSCIENCE

Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice

(2008) S. Saadoun et al.   BRAIN