Article
Neurosciences
Dylan Finneran, Qingyou Li, Meena S. Subbarayan, Aurelie Joly-Amado, Siddharth Kamath, Daniela G. Dengler, Marcia N. Gordon, Michael R. Jackson, Dave Morgan, Paula C. Bickford, Layton H. Smith, Kevin R. Nash
Summary: This study investigates the function and pharmacology of two commonly used isoforms of Fractalkine (FKN) and finds differences in cell activity and binding affinity, as well as the ineffectiveness of high concentrations of FKN in reducing inflammation. These findings provide a better understanding of the selection and interpretation of FKN peptides for in vitro and in vivo studies.
Review
Pharmacology & Pharmacy
Meena S. Subbarayan, Aurelie Joly-Amado, Paula C. Bickford, Kevin R. Nash
Summary: Neuroinflammation, mediated by CX3CL1/CX3CR1 signaling, plays a significant role in the development and progression of neurodegenerative diseases. CX3CL1 acts as a modulator, reducing inflammatory responses and exerting neuroprotective effects. However, it can also promote neurodegeneration. This review provides an overview of the complex nature of CX3CL1/CX3CR1 signaling in various neurodegenerative diseases.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Giulia Bivona, Matilda Iemmolo, Tommaso Piccoli, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Giulio Ghersi
Summary: Alzheimer's disease (AD) is the most common form of cognitive decline, characterized by aggregates of A beta and tau protein. In addition to A beta deposition, inflammation and microglia activation in the brain may also play a role in the pathogenesis of AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Peter Rappl, Silvia Roesser, Patrick Maul, Rebekka Bauer, Arnaud Huard, Yannick Schreiber, Dominique Thomas, Gerd Geisslinger, Per-Johan Jakobsson, Andreas Weigert, Bernhard Bruene, Tobias Schmid
Summary: mPGES-1 plays a crucial role in the resolution of acute inflammation, with its inhibition leading to an increase in inflammatory cell numbers. Inhibition of mPGES-1 was found to enhance CX3CR1 expression and promote the production of CX3CL1, affecting the adhesion and survival of M phi.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Amin Ullah, Jing Zhao, Rajeev K. Singla, Bairong Shen
Summary: This review discusses the role of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of preeclampsia and gestational diabetes mellitus (GDM) and investigates the potential of CXC-based therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yinhua Ni, Fen Zhuge, Liyang Ni, Naoto Nagata, Tatsuya Yamashita, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota, Mayumi Nagashimada
Summary: This study investigates the roles of CX3CL1/CX3CR1 in macrophage migration and polarization in the livers of NASH mice. It is found that CX3CL1 and CX3CR1 expression is upregulated in NASH mice livers, and CX3CR1 is predominantly expressed by F4/80+ macrophages. CX3CR1 deficiency leads to increased inflammatory monocyte/macrophage infiltration and a shift towards M1 dominant macrophages, exacerbating NASH progression. Deletion of CCL2 in CX3CR1-deficient mice alleviates NASH progression by reducing macrophage infiltration and inducing a shift towards M2 dominant macrophages.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Physiology
Diana Hamdan, Lisa A. Robinson
Summary: CX(3)CL1 is a key chemokine involved in kidney disease, playing diverse roles beyond leukocyte recruitment, including cell survival and immunoregulation. Understanding how CX(3)CL1 expression and function are regulated is essential to harness its therapeutic potential.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jineta Banerjee, Mauricio D. Dorfman, Rachael Fasnacht, John D. Douglass, Alice C. Wyse-Jackson, Andres Barria, Joshua P. Thaler
Summary: The study shows that suppressing hypothalamic microglial activation during high fat diet feeding can reduce susceptibility to diet-induced obesity by increasing POMC neuron excitability and melanocortin signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nur Balci, Ali Cekici, Sivge Kurgan, Selin Sahinkaya, Muhittin A. Serdar
Summary: This study aimed to determine differences in GCF and serum levels of fractalkine/CX3CL1 and its receptor/CX3CR1 between patients with periodontitis and healthy subjects. The results showed significantly higher levels of these factors in periodontitis patients, indicating a potential role in the pathogenesis of periodontal disease through regulation of inflammation.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Giulia Bivona, Matilda Iemmolo, Giulio Ghersi
Summary: Alzheimer's disease is a progressive disease with a lack of effective treatments. It is characterized by the deposition of amyloid beta and hyperphosphorylated tau protein aggregates in the brain. In addition to these classical hallmarks, microglia activation and chronic inflammation have gained attention as potential mechanisms underlying the pathogenesis of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yi-Hong Wu, Chen-Ying Wei, Wei-Chin Hong, Jong-Hwei Su Pang
Summary: Berberine has therapeutic effects in inflammation-associated diseases, including acute lung injury (ALI). The study showed that berberine alleviated LPS-induced lung injury through different anti-inflammatory mechanisms, including inhibiting the activation of the NF-kappa B and STAT3 signaling pathways. Berberine also effectively reduced the expression and shedding of CX3CL1, a molecule involved in leukocyte binding to the endothelium. These findings suggest that targeting the CX3CL1/CX3CR1 axis and ADAM10 pathway may be a potential therapeutic strategy for ALI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Sarah Cormican, Matthew D. Griffin
Summary: Innate immune cells play a key role in kidney inflammation and fibrosis, with the CX3CL1-CX3CR1 signaling pathway being closely linked to acute and chronic kidney diseases. Targeting this pathway may offer potential benefits for patients with CKD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yosra A. Hussien, Dina F. Mansour, Somaia A. Nada, Sahar S. Abd El-Rahman, Rania M. Abdelsalam, Amina S. Attia, Dalia M. El-Tanbouly
Summary: This study found that linagliptin can alleviate acute liver injury and hepatic encephalopathy induced by thioacetamide in rats, indicating its neuroprotective effect. Linagliptin achieves this effect by modulating inflammatory signaling, oxidative stress, and neurotransmitter levels.
Article
Biochemistry & Molecular Biology
Sei Muraoka, Kaichi Kaneko, Kaori Motomura, Junko Nishio, Toshihiro Nanki
Summary: Inflammatory conditions promote osteoclast differentiation with the help of CX3CL1, which plays a crucial role not only in accumulating inflammatory cells but also in regulating osteoclastogenesis in rheumatoid arthritis.
Article
Psychiatry
Jasmina Arabska, Adam Wysokinski, Ewa Brzezinska-Blaszczyk, Elzbieta Kozlowska
Summary: This study compared levels of interleukin in schizophrenia patients and healthy controls, finding higher levels of CXCL8 and lower levels of fractalkine in the patients. There was no significant difference in IL-10 levels between the two groups. Additionally, patients not taking mood stabilizers showed higher levels of CXCL8.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Aleksandra Rutkowska, Kumlesh K. Dev, Andreas W. Sailer
CURRENT DRUG TARGETS
(2016)
Review
Pharmacology & Pharmacy
Martin Madill, Denise Fitzgerald, Kara E. O'Connell, Kumlesh K. Dev, Sanbing Shen, Una FitzGerald
DRUG DISCOVERY TODAY
(2016)
Article
Immunology
Sinead A. O'Sullivan, Fabrizio Gasparini, Anis K. Mir, Kumlesh K. Dev
JOURNAL OF NEUROINFLAMMATION
(2016)
Article
Neurosciences
Sinead A. O'Sullivan, Maria Velasco-Estevez, Kumlesh K. Dev
Article
Immunology
Aleksandra Rutkowska, Andreas W. Sailer, Kumlesh K. Dev
JOURNAL OF NEUROINFLAMMATION
(2017)
Review
Neurosciences
Sinead O'Sullivan, Kumlesh K. Dev
Editorial Material
Neurosciences
K. K. Dev, A. J. Irving
Article
Neurosciences
Priyanka Dutta, Leila Dargahi, Kara E. O'Connell, Ashini Bolia, Banu Ozkan, Andreas W. Sailer, Kumlesh K. Dev
NEUROSCIENCE LETTERS
(2018)
Article
Multidisciplinary Sciences
Cedric Misslin, Maria Velasco-Estevez, Marie Albert, Sinead A. O'Sullivan, Kumlesh K. Dev
Article
Neurosciences
Maria Velasco-Estevez, Sara O. Rolle, Myrthe Mampay, Kumlesh K. Dev, Graham K. Sheridan
Article
Neurosciences
Maria Velasco-Estevez, Kamal K. E. Gadalla, Nuria Linan-Barba, Stuart Cobb, Kumlesh K. Dev, Graham K. Sheridan
Article
Neurosciences
Sibylle Bechet, Sinead A. O'Sullivan, Justin Yssel, Steven G. Fagan, Kumlesh K. Dev
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Kapil Sharma, Kumlesh K. Dev
Summary: The role of altered myelin in the onset and development of schizophrenia and changes in myelin due to antipsychotics remains unclear. However, this study suggests that antipsychotics directly regulate glial cell dysfunction and exert a protective effect on myelin loss. These findings may have implications for the potential use of antipsychotics in Krabbe disease.
Article
Clinical Neurology
Marianna Mekhaeil, Melissa Jane Conroy, Kumlesh Kumar Dev
Summary: Metachromatic leukodystrophy (MLD) is a severe genetic leukodystrophy characterized by deficits in the arylsulfatase A gene (ARSA) and accumulation of sulfatide. In an ex vivo cerebellar slice culture model, sulfatide was found to induce demyelination through PARP-1 activation, oligodendrocyte loss, inflammation, and gliosis. Treatment with the PARP-1 inhibitor Olaparib attenuated sulfatide-induced effects, indicating its potential therapeutic utility in rare demyelinating diseases.