期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 313, 期 -, 页码 145-151出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2017.09.012
关键词
Autoimmunity; Diazepam; Inflammatory T cells; TSPO
资金
- Consejo de Investigaciones Cientificas y Tecnicas (CONICET) [PIP 112-201101-00501]
- Agencia Nacional de Promocion Cientifica y Tecnologica (Prestamo BID) [PICT2011-799]
- Secretaria de Ciencia y Tecnologia de la Universidad Nacional de Cordoba (SeCyT-UNC), Argentina [05/C323]
- CONICET
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT2013-939]
- Universidad Nacional del Sur, Argentina
Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also, we evaluated the expression of Translocator Protein (18 kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b(+) cells.
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