期刊
JOURNAL OF NEUROGENETICS
卷 31, 期 3, 页码 70-87出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01677063.2017.1343316
关键词
Retina; reverse genetics; forward genetics; zebrafish; transgenesis
资金
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [31003A_153289, 31003A_173083]
- Swiss National Science Foundation (SNF) [31003A_153289] Funding Source: Swiss National Science Foundation (SNF)
The zebrafish (Danio rerio) possesses a vertebrate-type retina that is extraordinarily conserved in evolution. This well-organized and anatomically easily accessible part of the central nervous system has been widely investigated in zebrafish, promoting general understanding of retinal development, morphology, function and associated diseases. Over the recent years, genome and protein engineering as well as imaging techniques have experienced revolutionary advances and innovations, creating new possibilities and methods to study zebrafish development and function. In this review, we focus on some of these emerging technologies and how they may impact retinal research in the future. We place an emphasis on genetic techniques, such as transgenic approaches and the revolutionizing new possibilities in genome editing.
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