Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism

Injected Amyloid Beta in the Olfactory Bulb Transfers to Other Brain Regions via Neural Connections in Mice

(2017) Baixuan He et al.   MOLECULAR NEUROBIOLOGY

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

(2016) Alexander Jais et al.   CELL

Neuronal human BACE1 knockin induces systemic diabetes in mice

(2016) Kaja Plucińska et al.   DIABETOLOGIA

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

(2016) Leszek Szablewski   JOURNAL OF ALZHEIMERS DISEASE

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

(2016) Peter J. Meikle et al.   Nature Reviews Endocrinology

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes

(2015) Christopher J. Nolan et al.   DIABETES

Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism

(2015) F. Visiedo et al.   PLACENTA

Obesity and Hepatic Steatosis Are Associated with Elevated Serum Amyloid Beta in Metabolically Stressed APPswe/PS1dE9 Mice

(2015) Feng-Shiun Shie et al.   PLoS One

Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

(2014) Dirk Mossmann et al.   Cell Metabolism

Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?

(2014) Timothy Connor et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes

(2014) D. Lee Hamilton et al.   DIABETOLOGIA

Role of insulin resistance in Alzheimer’s disease

(2014) Zhiyou Cai et al.   METABOLIC BRAIN DISEASE

Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?

(2014) Paul Carrillo-Mora et al.   Oxidative Medicine and Cellular Longevity

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

(2013) Zheng Sun et al.   MOLECULAR CELL

Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

(2013) Noriko Hasebe et al.   PLoS One

Increased Aβ production prompts the onset of glucose intolerance and insulin resistance

(2012) Margarita Jiménez-Palomares et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease

(2012) Uwe Konietzko   Current Alzheimer Research

Amyloid-  Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway

(2012) Y. Zhang et al.   DIABETES

Amyloid-  Induces Hepatic Insulin Resistance In Vivo via JAK2

(2012) Y. Zhang et al.   DIABETES

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid   production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

(2012) P. Mao et al.   HUMAN MOLECULAR GENETICS

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

(2012) Julius Popp et al.   JOURNAL OF NEUROCHEMISTRY

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

(2011) Paul J. Meakin et al.   BIOCHEMICAL JOURNAL

Susceptibility to diet-induced obesity and glucose intolerance in the APP SWE/PSEN1 A246E mouse model of Alzheimer’s disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein

(2011) N. Mody et al.   DIABETOLOGIA

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexaenoic Acid Reduces Amyloid β Production via Multiple Pleiotropic Mechanisms

(2011) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease

(2011) Marcus O. W. Grimm et al.   JOURNAL OF NEUROCHEMISTRY

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism

(2011) Arlee Fafalios et al.   NATURE MEDICINE

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

The role of APP proteolytic processing in lipid metabolism

(2011) Marcus O. W. Grimm et al.   EXPERIMENTAL BRAIN RESEARCH

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

(2010) Leonardo M. Saraiva et al.   PLoS One

Mechanisms of obesity and related pathology: linking immune responses to metabolic stress

(2009) Katia P. Karalis et al.   FEBS Journal

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

(2009) Z. V. Goodger et al.   JOURNAL OF CELL SCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease

(2009) Alessio Colombo et al.   NEUROBIOLOGY OF DISEASE

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

(2008) Uwe Konietzko et al.   NEUROBIOLOGY OF AGING