Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms

Sex-dependent effects of developmental exposure to different pesticides on spatial learning. The role of induced neuroinflammation in the hippocampus

(2017) Belén Gómez-Giménez et al.   FOOD AND CHEMICAL TOXICOLOGY

Use of a probabilistic PBPK/PD model to calculate Data Derived Extrapolation Factors for chlorpyrifos

(2017) Torka S. Poet et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Spatial learning impairment in prepubertal guinea pigs prenatally exposed to the organophosphorus pesticide chlorpyrifos: Toxicological implications

(2016) Jacek Mamczarz et al.   NEUROTOXICOLOGY

Differential epigenetic effects of chlorpyrifos and arsenic in proliferating and differentiating human neural progenitor cells

(2016) Hee Yeon Kim et al.   REPRODUCTIVE TOXICOLOGY

Repeated exposure to neurotoxic levels of chlorpyrifos alters hippocampal expression of neurotrophins and neuropeptides

(2016) Young S. Lee et al.   TOXICOLOGY

Acetylcholine contributes to control the physiological inflammatory response during the peri-implantation period

(2015) D. Paparini et al.   Acta Physiologica

A review of epidemiologic studies of low-level exposures to organophosphorus insecticides in non-occupational populations

(2015) Richard Reiss et al.   CRITICAL REVIEWS IN TOXICOLOGY

Effect on theH19gene methylation of sperm and organs of offspring after chlorpyrifos-methyl exposure during organogenesis period

(2015) Hyo-Sook Shin et al.   ENVIRONMENTAL TOXICOLOGY

Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers

(2015) Steven T. Singleton et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Chlorpyrifos and malathion have opposite effects on behaviors and brain size that are not correlated to changes in AChE activity

(2015) Holly Richendrfer et al.   NEUROTOXICOLOGY

Prenatal exposure of guinea pigs to the organophosphorus pesticide chlorpyrifos disrupts the structural and functional integrity of the brain

(2015) Roger J. Mullins et al.   NEUROTOXICOLOGY

Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor

(2015) Virginia A. Rauh et al.   NEUROTOXICOLOGY

Neonatal chlorpyrifos exposure induces loss of dopaminergic neurons in young adult rats

(2015) Jie Zhang et al.   TOXICOLOGY

The effect of HMGB1 on sub-toxic chlorpyrifos exposure-induced neuroinflammation in amygdala of neonatal rats

(2015) Jing Tian et al.   TOXICOLOGY

Histone methylation during neural development

(2014) Deborah Roidl et al.   CELL AND TISSUE RESEARCH

Prenatal maternal factors in the development of cognitive impairments in the offspring

(2014) Juliet Richetto et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: Distribution, temporal variability, and relationship with child attention and hyperactivity

(2013) Gamola Z. Fortenberry et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: Significance for maternal stress and preterm labor

(2013) Edward D. Levin et al.   NEUROTOXICOLOGY AND TERATOLOGY

The organophosphate chlorpyrifos disturbs redox balance and triggers antioxidant defense mechanisms in JEG-3 cells

(2013) G. Chiapella et al.   PLACENTA

Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats

(2013) Xue-Han Zhang et al.   Molecular Brain

IGF2/H19 hypomethylation in a patient with very low birthweight, preocious pubarche and insulin resistance

(2012) Rinki Murphy et al.   BMC Medical Genetics

Selective cognitive impairments are related to selective hippocampus and prefrontal cortex deficits after prenatal chlorpyrifos exposure

(2012) Xiao-Ping Chen et al.   BRAIN RESEARCH

Neurobehavioral problems following low-level exposure to organophosphate pesticides: a systematic and meta-analytic review

(2012) Sarah Mackenzie Ross et al.   CRITICAL REVIEWS IN TOXICOLOGY

Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community

(2012) Karen Huen et al.   ENVIRONMENTAL RESEARCH

Contributions of inhalation and dermal exposure to chlorpyrifos dose in Egyptian cotton field workers

(2012) Richard A. Fenske et al.   INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

Does the home environment and the sex of the child modify the adverse effects of prenatal exposure to chlorpyrifos on child working memory?

(2012) Megan K. Horton et al.   NEUROTOXICOLOGY AND TERATOLOGY

Functional consequences of repeated organophosphate exposure: Potential non-cholinergic mechanisms

(2012) A.V. Terry   PHARMACOLOGY & THERAPEUTICS

Differentiating experimental animal doses from human exposures to chlorpyrifos

(2012) D. R. Juberg   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain anomalies in children exposed prenatally to a common organophosphate pesticide

(2012) V. A. Rauh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetics of early-life lead exposure and effects on brain development

(2012) Marie-Claude Senut et al.   Epigenomics

The alterations of oligodendrocyte, myelin in corpus callosum, and cognitive dysfunction following chronic cerebral ischemia in rats

(2011) Yuichiro Chida et al.   BRAIN RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Biomarkers of Chlorpyrifos Exposure and Effect in Egyptian Cotton Field Workers

(2011) Fayssal M. Farahat et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Prenatal Exposure to Organophosphates, Paraoxonase 1, and Cognitive Development in Childhood

(2011) Stephanie M. Engel et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos, a Common Agricultural Pesticide

(2011) Virginia Rauh et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Organophosphate Pesticide Exposure and Attention in Young Mexican-American Children: The CHAMACOS Study

(2010) Amy R. Marks et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Transgenic miR132 Alters Neuronal Spine Density and Impairs Novel Object Recognition Memory

(2010) Katelin F. Hansen et al.   PLoS One

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

(2010) S. T. Magill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice Treated with Chlorpyrifos or Chlorpyrifos Oxon Have Organophosphorylated Tubulin in the Brain and Disrupted Microtubule Structures, Suggesting a Role for Tubulin in Neurotoxicity Associated with Exposure to Organophosphorus Agents

(2010) Wei Jiang et al.   TOXICOLOGICAL SCIENCES

Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging

(2009) Edward D. Levin et al.   BEHAVIOURAL BRAIN RESEARCH

Protein kinase C is a target for diverse developmental neurotoxicants: Transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells

(2009) Theodore A. Slotkin et al.   BRAIN RESEARCH

American Healthy Homes Survey: A National Study of Residential Pesticides Measured from Floor Wipes

(2009) Daniel M. Stout II et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus

(2009) Emmanuel Galliot et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Oxidative stress from diverse developmental neurotoxicants: Antioxidants protect against lipid peroxidation without preventing cell loss

(2009) Theodore A. Slotkin et al.   NEUROTOXICOLOGY AND TERATOLOGY

Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: Comparison with nicotine and pilocarpine effects and relationship to dopamine deficits

(2009) Donnie Eddins et al.   NEUROTOXICOLOGY AND TERATOLOGY

Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero

(2009) Julia A. Haviland et al.   REPRODUCTIVE TOXICOLOGY

Developmental Chlorpyrifos and Methyl Parathion Exposure Alters Radial-Arm Maze Performance in Juvenile and Adult Rats

(2009) Frank O. Johnson et al.   TOXICOLOGICAL SCIENCES

Mass spectrometry identifies multiple organophosphorylated sites on tubulin

(2009) Hasmik Grigoryan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: A potential mechanism of long term toxicity by organophosphorus agents

(2008) Hasmik Grigoryan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

(2008) David L. Eaton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Pesticides and child neurodevelopment

(2008) Lisa G Rosas et al.   CURRENT OPINION IN PEDIATRICS

The Role of Neurotrophins During Early Development

(2008) PAULETTE BERND   GENE EXPRESSION

Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: Effects on serotonin systems in adolescence and adulthood

(2007) Theodore A. Slotkin et al.   BRAIN RESEARCH BULLETIN

Characterization of chlorpyrifos-induced apoptosis in placental cells

(2007) Marilyn D. Saulsbury et al.   TOXICOLOGY

Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase

(2007) Dongren Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY