Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

(2017) Graham H. Diering et al.   SCIENCE

Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences

(2016) Li Ye et al.   CELL

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

(2016) Nicolas Renier et al.   CELL

Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy

(2016) Shengjie Feng et al.   EMBO REPORTS

Interictal epileptiform discharges induce hippocampal–cortical coupling in temporal lobe epilepsy

(2016) Jennifer N Gelinas et al.   NATURE MEDICINE

Lrp4 in astrocytes modulates glutamatergic transmission

(2016) Xiang-Dong Sun et al.   NATURE NEUROSCIENCE

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

(2016) Taku Nagai et al.   NEURON

Npas4: Linking Neuronal Activity to Memory

(2016) Xiaochen Sun et al.   TRENDS IN NEUROSCIENCES

Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells

(2015) Thilo Speckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus

(2015) Bin Gu et al.   NEURON

Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs

(2014) Ivo Spiegel et al.   CELL

An unknown quantity-The worldwide prevalence of epilepsy

(2014) Gail S. Bell et al.   EPILEPSIA

Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor

(2014) T. Nakai et al.   JOURNAL OF NEUROSCIENCE

Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus

(2014) Ikram Ullah et al.   NEUROMOLECULAR MEDICINE

Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons

(2014) Sei-ichi Yoshihara et al.   Cell Reports

Increased Cell-Intrinsic Excitability Induces Synaptic Changes in New Neurons in the Adult Dentate Gyrus That Require Npas4

(2013) S. Sim et al.   JOURNAL OF NEUROSCIENCE

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice

(2013) Thongchai Sooksawate et al.   Frontiers in Neural Circuits

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Pilocarpine-induced status epilepticus increases Homer1a and changes mGluR5 expression

(2012) C.F. Cavarsan et al.   EPILEPSY RESEARCH

Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter

(2012) Yoko Furukawa-Hibi et al.   JOURNAL OF NEUROCHEMISTRY

Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement

(2011) Gina Turrigiano   Annual Review of Neuroscience

PSD-95 and PSD-93 Play Critical But Distinct Roles in Synaptic Scaling Up and Down

(2011) Q. Sun et al.   JOURNAL OF NEUROSCIENCE

Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

(2011) H. Mizoguchi et al.   JOURNAL OF NEUROSCIENCE

Neuronal homeostasis: time for a change?

(2011) Timothy O’Leary et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy

(2011) Ke-Xin Li et al.   NATURE NEUROSCIENCE

Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons

(2011) Guo-He Tan et al.   NATURE NEUROSCIENCE

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation

(2011) K. Ramamoorthi et al.   SCIENCE

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

(2010) Jaesuk Yun et al.   JOURNAL OF NEUROCHEMISTRY

Homeostatic Scaling Requires Group I mGluR Activation Mediated by Homer1a

(2010) Jia-Hua Hu et al.   NEURON

The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure

(2009) Mariko Kato Hayashi et al.   CELL

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses

(2008) Gina G. Turrigiano   CELL

Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients

(2008) Idil Cavus et al.   EPILEPSIA

Activity-Induced Polo-Like Kinase 2 Is Required for Homeostatic Plasticity of Hippocampal Neurons during Epileptiform Activity

(2008) D. P. Seeburg et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing

(2008) Keiji Ibata et al.   NEURON