Article
Neurosciences
Mariana Pereira, Sofia Rita Fernandes, Pedro Cavaleiro Miranda, Mamede de Carvalho
Summary: The study aims to define the optimal tsDCS montage for maximizing the electric field in the lumbar spinal cord through computer modeling, and to measure its effect on LMN excitability and SSEPs.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Noah Bryson, Lorenzo Lombardi, Rachel Hawthorn, Jie Fei, Rodolfo Keesey, J. D. Peiffer, Ismael Seanez
Summary: This study investigated whether muscle recruitment selectivity of individual muscles could be enhanced by multielectrode configurations of transcutaneous spinal cord stimulation (tSCS) in neurologically intact individuals. The results showed that multielectrode configurations improved the selectivity and activation of specific muscles, potentially enhancing single-joint movements in neurorehabilitation.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Agriculture, Dairy & Animal Science
Angela Martins, Catia Marina Silva, Debora Gouveia, Ana Cardoso, Tiago Coelho, Oscar Gamboa, Eduardo Marcelino, Antonio Ferreira
Summary: The study demonstrates the importance of intensive neurorehabilitation in promoting ambulation recovery in paraplegic animals, leading to improved quality of life and potentially reducing the number of euthanasia procedures performed on these animals.
Review
Neurosciences
Yury Ivanenko, Elena Y. Shapkova, Daria A. Petrova, Daria F. Kleeva, Mikhail A. Lebedev
Summary: Neuromodulation through spinal cord electrical stimulation (SCES) is effective in restoring function, but its effectiveness can be enhanced by combining it with exoskeleton gait training (EGT) that promotes activity-dependent plasticity. Assessing individual characteristics of spinal cord function is important for developing personalized SCES and EGT therapies. Combining SCES and EGT can have a synergistic rehabilitative effect on restoring multiple functions in paralyzed individuals.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Biology
Yann Roussel, Stephanie F. Gaudreau, Emily R. Kacer, Mohini Sengupta, Tuan Bui
Summary: This study builds models of developing zebrafish spinal circuits and simulates the underlying mechanisms of swimming movements. The simulations reveal the relationships between neuronal firing patterns and developmental stages, highlighting some key features of zebrafish locomotion.
Article
Rehabilitation
Jason Liang, Julio C. Furlan
Summary: This study investigated the frequency and types of peripheral neuropathy in the lower limbs of patients undergoing rehabilitation after traumatic spinal cord injury or spinal cord disease. It found that diseases of the peripheral nervous system were similarly found among patients undergoing rehabilitation for either spinal cord injury or spinal cord disease, with a length-dependent polyneuropathy diagnosed in 0.77% of all admissions.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Engineering, Biomedical
Guijin Li, Gustavo Balbinot, Julio C. Furlan, Sukhvinder Kalsi-Ryan, Jose Zariffa
Summary: This study used computational models to investigate changes in sEMG signal after SCI and identify sEMG features that are sensitive and specific to different aspects of the injury. The results showed that commonly used amplitude-based sEMG features cannot differentiate between injury scenarios, but a broader set of features provides greater specificity to the type of damage present.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Camilla Pierella, Elisa Galofaro, Alice De Luca, Luca Losio, Simona Gamba, Antonino Massone, Ferdinando A. Mussa-Ivaldi, Maura Casadio
Summary: This study explored the use of BoMI to promote whole-arm mobility and developed an assessment protocol and kinematic indicators to evaluate residual abilities and recovery. The preliminary outcomes support the efficacy of BoMI as a rehabilitation tool and suggest potential for clinical practice.
Article
Engineering, Biomedical
David J. Houston, Janelle Unger, Jae W. Lee, Kei Masani, Kristin E. Musselman
Summary: The study found that participants in the FES + VFBT program perceived benefits that led to meaningful improvements in activities of daily living and felt they still had the capacity to improve. They felt they had increased their balance confidence, while a few participants also reported a decrease in their risk of falling. The inclusion of qualitative inquiry allows for the evaluation of the meaningfulness of an intervention and its perceived impact on the lives of the participants.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Neurosciences
Shashank Ghai
Summary: There is limited knowledge about the effects of music therapy-based auditory stimulation (MT) on gait outcomes in individuals with traumatic brain injury (TBI) or spinal cord injury (SCI). This meta-analysis found that MT has positive medium effect improvements on spatiotemporal aspects of gait in individuals with TBI (Hedge's g: 0.52) and SCI (0.53). Further research is needed to fully understand the mechanisms by which MT may influence gait and determine the optimal parameters for its use.
Review
Biochemistry & Molecular Biology
Paola Marangolo, Simona Vasta, Alessio Manfredini, Carlo Caltagirone
Summary: The traditional view of the spinal cord as a bundle of fibers connecting the brain to the body has restricted its study to peripheral sensory and motor control. However, new studies have shown the spinal cord's involvement in motor skill acquisition, cortical neuroplasticity, and modulation of motor and cognitive functions. By activating corticospinal pathways, transpinal direct current stimulation (tsDCS) can promote local and cortical neuroplasticity changes, which may have implications for post-stroke recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Claudia Angeli, Sarah Wagers, Susan Harkema, Enrico Rejc
Summary: This study presents a case of an individual with a chronic, cervical-level complete motor and sensory injury who was able to perform voluntary movements of both upper and lower extremities in a sensory-rich environment. It demonstrates that the human spinal circuitry can generate motor patterns for various tasks even without clinically detectable supraspinal input, as long as appropriate sensory information is available.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Maria Grazia Maggio, Mirjam Bonanno, Alfredo Manuli, Maria Pia Onesta, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabro
Summary: This study aimed to evaluate the effects of semi-immersive virtual reality cognitive training on global functional recovery in patients with spinal cord injury. The findings showed that compared to traditional therapy, training using semi-immersive VR significantly improved patients' cognitive functioning, mood, and overall quality of life, especially in physical perception.
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Johannie Audet, Charly G. Lecomte
Summary: Tonic or phasic electrical epidural stimulation in the lumbosacral region can improve locomotion and standing in severe spinal cord injury models, but the mechanisms behind this remain largely unknown. There are limitations that currently prevent the widespread clinical implementation of this promising therapeutic approach.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Edwin H. F. van Asseldonk, Tjitske A. Boonstra
Article
Engineering, Biomedical
Jos Meuleman, Edwin van Asseldonk, Gijs van Oort, Hans Rietman, Herman van der Kooij
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2016)
Article
Robotics
Bram Koopman, Edwin H. F. van Asseldonk, Herman van der Kooij
IEEE TRANSACTIONS ON ROBOTICS
(2016)
Article
Biology
M. Vlutters, E. H. F. van Asseldonk, H. van der Kooij
JOURNAL OF EXPERIMENTAL BIOLOGY
(2016)
Review
Engineering, Biomedical
Serena Maggioni, Alejandro Melendez-Calderon, Edwin van Asseldonk, Verena Klamroth-Marganska, Lars Lunenburger, Robert Riener, Herman van der Kooij
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2016)
Article
Computer Science, Artificial Intelligence
Amy R. Wu, Florin Dzeladini, Tycho J. H. Brug, Federica Tamburella, Nevio L. Tagliamonte, Edwin H. F. van Asseldonk, Herman van der Kooij, Auke J. Ijspeert
FRONTIERS IN NEUROROBOTICS
(2017)
Article
Multidisciplinary Sciences
Fokke B. van Meulen, Dirk Weenk, Edwin H. F. van Asseldonk, H. Martin Schepers, Peter H. Veltink, Jaap H. Buurke
Article
Chemistry, Analytical
Cristina Bayon, Gabriel Delgado-Oleas, Leticia Avellar, Francesca Bentivoglio, Francesco Di Tommaso, Nevio L. Tagliamonte, Eduardo Rocon, Edwin H. F. van Asseldonk
Summary: Recent advances in the control of overground exoskeletons are focused on improving balance support and reducing reliance on crutches. However, there is a lack of appropriate methods to quantify the stability of these exoskeletons and their users. This study presents the BenchBalance system, a benchmarking solution for reproducible balance assessments of exoskeletons and their users.
Article
Engineering, Mechanical
Wolfgang Rampeltshammer, Arvid Keemink, Menno Sytsma, Edwin van Asseldonk, Herman van der Kooij
Summary: This work introduces a unified theoretical and experimental framework for comparing different torque controllers based on their torque transfer behavior, apparent impedance behavior, interaction stability, and sensitivity to sensor noise. Simulations and experiments demonstrate the trade-off between stable interactions, high bandwidths, and low noise levels, allowing the design of application-specific controllers for desired interaction with the environment.
Proceedings Paper
Computer Science, Artificial Intelligence
Herman van der Kooij, Edwin H. F. van Asseldonk, Mark Vlutters
WEARABLE ROBOTICS: CHALLENGES AND TRENDS
(2017)
Proceedings Paper
Computer Science, Artificial Intelligence
Mark Vlutters, Edwin H. F. van Asseldonk, Herman van der Kooij
WEARABLE ROBOTICS: CHALLENGES AND TRENDS
(2017)
Proceedings Paper
Computer Science, Artificial Intelligence
Amy R. Wu, Florin Dzeladini, Tycho J. H. Brug, Federica Tamburella, Nevio L. Tagliamonte, Edwin van Asseldonk, Herman van der Kooij, Auke J. Ijspeert
WEARABLE ROBOTICS: CHALLENGES AND TRENDS
(2017)
Proceedings Paper
Computer Science, Artificial Intelligence
Amber Emmens, Iolanda Pisotta, Marcella Masciullo, Edwin van Asseldonk, Herman van der Kooij
WEARABLE ROBOTICS: CHALLENGES AND TRENDS
(2017)
Article
Psychology, Multidisciplinary
Jonathan S. Barnhoorn, Falko R. Doehring, Edwin H. F. Van Asseldonk, Willem B. Verwey
FRONTIERS IN PSYCHOLOGY
(2016)