Article
Materials Science, Ceramics
Jongmoon Jang, Pradeep Vallachira Warriam Sasikumar, Fatemeh Navaee, Lorenz Hageluken, Gurdial Blugan, Juergen Brugger
Summary: The electrochemical behavior of polymer-derived silicon oxycarbide (SiOC) and titanium-doped SiOC (SiTiOC) ceramic electrodes for use as pacemaker electrodes was investigated. Results showed that the SiOC and SiTiOC electrodes displayed wide electrochemical stability and had potential as candidate materials for next-generation pacemaker electrodes.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Yu Huan, Jeffrey P. Gill, Johanna B. Fritzinger, Paras R. Patel, Julianna M. Richie, Elena Della Valle, James D. Weiland, Cynthia A. Chestek, Hillel J. Chiel
Summary: Carbon fiber electrodes (CFEs) show potential for stable intracellular stimulation and recording with good signal-to-noise ratios, allowing for multi-neuron recording simultaneously. Despite lower amplitudes compared to glass microelectrodes, CFEs provide a powerful new technology for studying neural circuit dynamics.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Xi Tang, Yuanzhe Dong, Qingge Li, Zhiyuan Liu, Nan Yan, Yongcheng Li, Bin Liu, Lelun Jiang, Rong Song, Yingying Wang, Guanglin Li, Peng Fang
Summary: In this study, a microneedle array electrode (MAE) was fabricated using a magnetization-induced self-assembly method. Compared to traditional metal-based flat array electrodes (FAE), MAEs showed significantly lower and more stable electrode-skin interface impedance, higher signal-to-noise ratio (SNR) and motion-intention classification accuracy. The successful sensation evoking also demonstrated the feasibility of the MAE-based electrical stimulation for sensory feedback. This study confirms the application potential of MAEs as an effective neural interface for human-machine interaction (HMI), providing technical support for its development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Carmen de la Torre-Gamarra, MariaEugenia Sotomayor, Wilmer Bucheli, JoseManuel Amarilla, Jean-Yves Sanchez, Belen Levenfeld, Alejandro Varez
Summary: This work demonstrates the preparation of additive-free ceramic Li4Ti5O12 (LTO) electrodes with high thickness by optimizing the sintering process and using a reducing atmosphere. The absence of binders in the final electrode leads to very high volumetric and areal capacities, paving the way for large-scale production of thick electrodes for applications in all-solid-state batteries, improving the safety of lithium-ion batteries.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Chemistry, Physical
Yuntao Guo, Xinhai Li, Huajun Guo, Qianwan Qin, Zhixing Wang, Jiexi Wang, Guochun Yan
Summary: This study investigates the influence of concentration polarization on the crystal structure and chemical properties of active materials in thick electrodes. It verifies the existence of concentration polarization in the configuration of thin-electrode-stacking cells (Scells) for the first time and visualizes the gradient distribution of Li solid-phase content on the section of the thick electrodes using Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS). Additionally, it clarifies the mechanism of alleviating concentration polarization by constructing holes array on thick electrodes through electrochemical simulation.
ENERGY STORAGE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lukas Neidhart, Katja Froehlich, Nicolas Eshraghi, Damian Cupid, Franz Winter, Marcus Jahn
Summary: This study aims to address electrode integrity issues and improve electrochemical performance in the manufacturing of thick electrodes for Li-ion batteries. By implementing a multi-layered coating, an increase in specific discharge capacity can be achieved.
Article
Electrochemistry
Qingjie Wang, Sandrine Ricote, Ming Chen
Summary: Protonic ceramic cells (PCCs), including protonic ceramic fuel cells (PCFCs) and electrolysis cells (PCECs), have advantages such as low activation energy for proton diffusion, fuel flexibility, absence of fuel dilution, and potentially lower costs. However, the design of efficient oxygen electrodes is a major challenge for PCCs. Research groups have made efforts to improve the oxygen electrode, resulting in enhanced power output and current density in PCCs. This review article summarizes the progress in oxygen electrodes for PCCs and provides potential pathways for further development of high-performance electrodes.
ELECTROCHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Hiroyuki Muto, Yusaku Sato, Wai Kian Tan, Atsushi Yokoi, Go Kawamura, Atsunori Matsuda
Summary: This study demonstrates the controlled incorporation of carbon nanotubes (CNT) with alumina and zirconia nanoparticles using an electrostatic nano-assembly method, resulting in the fabrication of homogeneous composite granules. The spark-plasma-sintered composite granules exhibited significantly higher electrical conductivity compared to a homogeneous composite artifact. This novel fabrication method using electrostatic integrated assembly shows potential for the development of multiscale and multicomponent composite materials.
Review
Chemistry, Multidisciplinary
Guoying Zhang, Shaohua Jiang, Il-Doo Kim, Feng Wang, Jiyoung Lee, Lian Chen, Shuijian He, Jingquan Han, Jaewan Ahn, Jun Young Cheong
Summary: The emergence and development of thick electrodes have provided an efficient way for designing high-energy-density supercapacitors. Wood, as a biomass material, possesses a porous hierarchical structure with advantages such as straight channels, uniform pore distribution, good mechanical strength, and easy processing. This review summarizes the design concepts and processing parameters of thick electrode supercapacitors inspired by wood, including wood-based pore structural design, electric double layer capacitance construction, and electrical conductivity optimization. The optimization strategies for preparing wood-inspired thick electrodes, such as 3D printing and freeze-drying, are also discussed, along with current challenges and future trends in this field.
Article
Materials Science, Biomaterials
Md. . Kabir Uddin Sikder, Wei Tong, Hitesh Pingle, Peter Kingshott, Karina Needham, Mohit N. Shivdasani, James B. Fallon, Peter Seligman, Michael R. Ibbotson, Steven Prawer, David J. Garrett
Summary: Coating electrodes with biomolecules like extracellular matrix proteins can suppress adverse biological responses and maintain optimal electrochemical performance for neural stimulation. The method of covalently coupling biomolecules to diamond electrodes enhances cell attachment densities and neurite outgrowth, showing promise in reducing inflammatory responses in vivo.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Juyoung Kwon, Jong Seung Lee, Jaejun Lee, Jukwan Na, Jaesuk Sung, Hyo-Jung Lee, Hankyul Kwak, Eunji Cheong, Seung-Woo Cho, Heon-Jin Choi
Summary: The development of vertical nanowire electrode array (VNEA) as a new intracellular electrical stimulation method shows promising results for promoting electrophysiological functional maturation and neuronal differentiation of cells through direct delivery of intracellular electrical potential and current via nanoelectrodes.
Review
Chemistry, Multidisciplinary
Arman Ahnood, Andre Chambers, Amy Gelmi, Ken-Tye Yong, Omid Kavehei
Summary: The advent of electronic technology for neural interfacing in the past 50 years has transformed medicine and biology. Devices like deep brain stimulators and cochlear implants have revolutionized the treatment of previously untreatable conditions. Semiconducting electrodes have advanced neural interfacing technologies, enabling high precision sensing and stimulation in electrical, biochemical, and optical domains. This emerging class of electrodes offers new opportunities for research and treatment.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Analytical
Longbin Qi, Rongning Liang, Tianjia Jiang, Wei Qin
Summary: Reliable potentiometric ion sensing in complex samples remains a great challenge for polymeric membrane ion-selective electrodes (ISEs). Electrode fouling caused by the adsorptions of organic molecules and biological cells seriously affects the performance of ISEs. Development of polymeric membranes with fouling resistance is a fundamental strategy to address this issue and has become an important research direction.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Ceramics
I. Romero-Garcia, M. E. Sotomayor, B. Levenfeld, A. Varez, A. Varzi, G. T. Kim, S. Passerini
Summary: In this study, ultra-thick binder-free ceramic electrodes were processed using powder injection moulding (PIM) technique. The resulting electrodes showed high energy density and safety. The specific synthesis process allowed for high porosity electrodes, which exhibited very high capacities in half-cell experiments.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2024)
Article
Engineering, Manufacturing
Yingjun Zeng, Guochun Chen, Fuxin Zhao, Chao Wu, Lida Xu, Xiaochuan Pan, Fan Lin, Lanlan Li, Gonghan He, Qinnan Chen, Daoheng Sun, Zhenyin Hai
Summary: In this study, a high-temperature thick film platinum (Pt) RTD array based on 3D printing technology is presented for high-temperature field measurement sensing applications at 50-800 degrees C. The analysis of microstructure, phase composition, and electrical properties revealed three stages of Pt film sintering during the sintering process. The printed Pt films, confirmed to contain glass powder, exhibit excellent anti-aggregation and high-temperature properties compared to sputtered films. The resulting Pt RTD array shows outstanding stability (drift rate of 0.07%/h at 800 degrees C) and high accuracy (0.75% fullscale), and can realize temperature gradient monitoring of a two-dimensional temperature field. The potential applications of the Pt RTD array, including bolt and rocket engine tester exhaust flame temperature monitoring, were demonstrated. This study paves the way for printing RTD arrays directly on curved parts.
ADDITIVE MANUFACTURING
(2023)
Article
Engineering, Biomedical
Adrien Debelle, Myriam Hesta, Hilde de Rooster, Erika Bianchini, Anne Vanhoestenberghe, Emmelie Stock, Katrien Vanderperren, Ingeborgh Polis, Hugo Smets, Joaquin Cury, Vicente Acuna, Alain Delchambre, Bernardo Innocenti, Jacques Deviere, Antoine Nonclercq
Summary: Adaptive gastric electrical stimulation (GES) is effective in reducing food intake and maintaining lean weight, overcoming habituation to GES and inter-subject variation.
Review
Engineering, Biomedical
Lei Jiang, Ben Woodington, Alejandro Carnicer-Lombarte, George Malliaras, Damiano G. Barone
Summary: Bioelectronic stimulation of the spinal cord has made significant progress in restoring motor function in spinal cord injury (SCI). The recording and generation of control signals from the uninjured spinal cord has been achieved, allowing for targeted stimulation. Technological advances in flexible materials, electrode impedance, and signal analysis have improved spinal cord recording (SCR) for future neuroprosthetics. This review summarizes these advances and addresses the clinical challenges of spinal cord bioelectronic interfaces and potential solutions, from device manufacture to chronic effects of foreign body reaction and electrode compatibility issues. Additionally, the review presents the vision of a bi-directional closed-loop spinal cord bioelectronic bypass interface for restoring motor function in SCI cases.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Biochemical Research Methods
Joaquin Cury, Hugo Smets, Caroline Bouzin, Pascal Doguet, Anne Vanhoestenberghe, Jean Delbeke, Riem El Tahry, Antoine Nonclercq, Simon-Pierre Gorza
Summary: This study explored the measurement of birefringence variations related to nerve activity and its efficiency on mammal peripheral nerves. The results showed successful detection of nerve activity using birefringence in crustaceans, but no optical signal was detected in rats. It is hypothesized that the absence of birefringence signals in rats may be attributed to the presence of myelin sheets.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Chemistry, Multidisciplinary
Alexander J. Boys, Alejandro Carnicer-Lombarte, Amparo Gueemes-Gonzalez, Douglas C. van Niekerk, Sam Hilton, Damiano G. Barone, Christopher M. Proctor, Roisin M. Owens, George G. Malliaras
Summary: Bioelectronics is crucial for understanding and treating disease, but stable, long-term interfaces with the body are challenging. Combining techniques from regenerative medicine and electronics can create implants that integrate with tissue and enable sophisticated recording and stimulation. A hybrid implant system using a microelectrode array and a bioresorbable gel is constructed and shown to produce minimal foreign body response when implanted in muscle, allowing for long-term electromyographic signal recording with high resolution. This opens up possibilities for a new generation of long-term implantable electronics.
ADVANCED MATERIALS
(2023)
Review
Engineering, Biomedical
Thomas Niederhoffer, Anne Vanhoestenberghe, Henry T. Lancashire
Summary: This review compares the methods of electrodeposition of PEDOT on metal neural electrodes and analyzes their effects on morphology and electrochemical performance. The results show that the deposition charge density of PEDOT positively correlates with coating thickness and charge storage capacity. The choice of co-ion in PEDOT deposition affects the coating structure and morphology, with limited influence on charge storage capacity and impedance. The significance of this review lies in providing a common basis for researchers working with PEDOT and setting a standard for accurate and uniform reporting of methods.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Amy E. Rochford, Alejandro Carnicer-Lombarte, Malak Kawan, Amy Jin, Sam Hilton, Vincenzo F. Curto, Alexandra L. Rutz, Thomas Moreau, Mark R. N. Kotter, George G. Malliaras, Damiano G. Barone
Summary: The development of neural interfaces with improved biocompatibility and tissue integration is crucial for restoring neurological functions in the nervous system. To increase the resolution for mapping neuronal inputs onto implants, a new type of neural interface using iPSC-derived myocytes as biological targets has been developed. Long-term survival and functional integration of this biohybrid device have been demonstrated in freely moving rats, showing potential for restorative therapies using regenerative bioelectronics.
Article
Engineering, Biomedical
Jacqueline Beddoe-Rosendo, Clare L. Heaysman, Joseph Hajnal, Sebastien Ourselin, Anne Vanhoestenberghe
Summary: The increase in regulatory challenges on medical technology in the UK is hindering innovation. The limited capacity of Approved and Notified Bodies serves as another barrier in the innovation pipeline, potentially leading more teams to seek FDA approval rather than UKCA marking, which may limit the benefits patients can receive from research conducted in UK universities.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2023)
Proceedings Paper
Engineering, Biomedical
Thomas Niederhoffer, Anne Vanhoestenberghe, Henry T. Lancashire
Summary: Platinum is a commonly used electrode material for neural interfaces and electrochemical biosensors, but it can undergo faradaic reactions that lead to platinum dissolution and tissue damage. This study investigates the influence of electrolyte on platinum dissolution mechanisms and demonstrates the importance of carefully selecting stimulation protocols and electrolytes to avoid platinum dissolution and tissue damage.
2023 IEEE BIOSENSORS CONFERENCE, BIOSENSORS
(2023)
Review
Rehabilitation
Sarah Massey, Anne Vanhoestenberghe, Lynsey Duffell
Summary: This systematic review and meta-analysis examined the effectiveness of non-invasive electrical stimulation (ES) in reducing spasticity in individuals with spinal cord injury (SCI). The results showed that non-invasive ES can effectively reduce spasticity, but further research is needed to establish the correlation between clinical and neurophysiological outcomes.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Minghao Li, Anne Vanhoestenberghe, Sara S. Ghoreishizadeh
Summary: This paper presents the design of an integrated circuit for electrochemical sensors, including a current reference circuit and a current readout circuit, and the performance of the circuits under specific process conditions was simulated and tested.
2022 IEEE 13TH LATIN AMERICAN SYMPOSIUM ON CIRCUITS AND SYSTEMS (LASCAS)
(2022)
Article
Engineering, Biomedical
Fangqi Liu, Yu Wu, Noora Almarri, Maryam Habibollahi, Henry Thomas Lancashire, Barney Bryson, Linda Greensmith, Dai Jiang, Andreas Demosthenous
Summary: This paper presents a fully implantable closed-loop device for investigating new treatments for motor neuron disease in freely moving rodents. The device features multiple stimulators and a neural recording front-end, and is powered by a wireless inductive link and a backup rechargeable battery. Control is achieved via a Bluetooth telemetry link. Measured results demonstrate the performance of the electronics and packaging method.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Minghao Li, Atal A. S. Gill, Anne Vanhoestenberghe, Sara S. Ghoreishizadeh
Summary: This paper presents the design of an integrated circuit for galvanostatic deposition and amperometric readout of electrochemical sensors. The circuit is designed to generate stable currents with low sensitivity to process, power supply voltage, and temperature. The feasibility of on-chip electrodeposition was demonstrated by successfully depositing a gold layer on top of electrodes.
2022 29TH IEEE INTERNATIONAL CONFERENCE ON ELECTRONICS, CIRCUITS AND SYSTEMS (IEEE ICECS 2022)
(2022)
Review
Surgery
Ariadni Papadopoulou, Niraj S. Kumar, Anne Vanhoestenberghe, Nader K. Francis
Summary: This review investigates the carbon and material footprint of minimally invasive surgical (MIS) techniques and summarizes strategies to make MIS greener. It found that robotic procedures result in higher greenhouse gas emissions and waste production compared to laparoscopic alternatives, with the production of disposables and anaesthetics being carbon footprint hotspots. Waste reduction strategies include repackaging disposables and limiting unused instruments.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Chemistry, Multidisciplinary
Johannes Gurke, Tobias E. Naegele, Sam Hilton, Roberto Pezone, Vincenzo F. Curto, Damiano G. Barone, Emil J. W. List-Kratochvil, Alejandro Carnicer-Lombarte, George G. Malliaras
Summary: New fabrication approaches for mechanically flexible implants combining thin film microfabrication and additive manufacturing have been demonstrated. These implants with electrode arrays and microfluidic channels can modulate neuronal activity in the hippocampus through localized drug delivery while recording brain activity by its electrodes. The good implant stability and minimal tissue response observed in this study suggest the potential of hybrid fabrication in neurotechnology for the development of multimodal implants.
MATERIALS HORIZONS
(2022)