4.6 Article

Correspondence between visual and electrical input filters of ON and OFF mouse retinal ganglion cells

期刊

JOURNAL OF NEURAL ENGINEERING
卷 14, 期 4, 页码 -

出版社

IOP PUBLISHING LTD
DOI: 10.1088/1741-2552/aa722c

关键词

prosthesis; white noise analysis; preferential stimulation; linear systems analysis; retinal physiology

资金

  1. German Federal Ministry of Education and Research (BMBF) [031 A 308]
  2. Bernstein Centre for Computational Neuroscience, Tuebingen - BMBF [01GQ1002]
  3. German Ophthalmology Society (DOG)
  4. PRO RETINA foundation for prevention of blindness
  5. Tistou and Charlotte Kerstan Foundation
  6. Werner Reichardt Centre for Integrative Neuroscience (CIN) at the Eberhard-Karls University of Tubingen
  7. CIN is an Excellence Cluster - German Research Foundation (DFG) within the framework of the Excellence Initiative [EXC 307]

向作者/读者索取更多资源

Objective. Over the past two decades retinal prostheses have made major strides in restoring functional vision to patients blinded by diseases such as retinitis pigmentosa. Presently, implants use single pulses to activate the retina. Though this stimulation paradigm has proved beneficial to patients, an unresolved problem is the inability to selectively stimulate the on and off visual pathways. To this end our goal was to test, using white noise, voltage-controlled, cathodic, monophasic pulse stimulation, whether different retinal ganglion cell (RGC) types in the wild type retina have different electrical input filters. This is an important precursor to addressing pathway-selective stimulation. Approach. Using full-field visual flash and electrical and visual Gaussian noise stimulation, combined with the technique of spike-triggered averaging (STA), we calculate the electrical and visual input filters for different types of RGCs (classified as on, off or on-off based on their response to the flash stimuli). Main results. Examining the STAs, we found that the spiking activity of on cells during electrical stimulation correlates with a decrease in the voltage magnitude preceding a spike, while the spiking activity of off cells correlates with an increase in the voltage preceding a spike. No electrical preference was found for on-off cells. Comparing STAs of wild type and rd10 mice revealed narrower electrical STA deflections with shorter latencies in rd10. Significance. This study is the first comparison of visual cell types and their corresponding temporal electrical input filters in the retina. The altered input filters in degenerated rd10 retinas are consistent with photoreceptor stimulation underlying visual type-specific electrical STA shapes in wild type retina. It is therefore conceivable that existing implants could target partially degenerated photoreceptors that have only lost their outer segments, but not somas, to selectively activate the on and off visual pathways.

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