期刊
JOURNAL OF NATURAL PRODUCTS
卷 80, 期 4, 页码 1161-1166出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00137
关键词
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资金
- JSPS KAKENHI [16H03285]
- Naito Foundation
- Grants-in-Aid for Scientific Research [15K01803, 16H03285] Funding Source: KAKEN
Biseokeaniamides A, B, and C (1-3), structurally novel sterol O-acyltransferase (SOAT) inhibitors; were isolated from an Okeania sp. marine cyanobacterium. Their structures were elucidated by spectroscopic analyses and degradation reactions. Biseokeaniamide B (2) exhibited moderate cytotoxicity against human HeLa cancer cells, and compounds 1-3 inhibited both SOAT1 and SOAT2, not only at an enzyme level but also at a cellular level. Biseokeaniamides (1-3) are the first linear lipopeptides that have been shown to exhibit SOAT-inhibitory activity.
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