Article
Chemistry, Multidisciplinary
Lin Chen, Zhihui Luo, Chen Zhao, Qinglan Li, Yingjie Geng, Yong Xiao, Ming-Kai Chen, Lianyun Li, Zhen-Xia Chen, Min Wu
Summary: In this study, a systematic epigenomic study of histone modifications in an AOM-DSS-induced CRC mouse model is conducted. The dynamic landscape of chromatin states during inflammation-cancer transition is illustrated and functional gene clusters and key signaling pathways are identified. The study reveals the important role of enhancer state regions during inflammation-cancer transition and experimentally confirms OTX2 as a critical tumor suppressive transcription factor.
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemical Research Methods
Elias Orouji, Ayush T. Raman
Summary: The human genome is shaped by a variety of histone modifications, which play a crucial role in determining chromatin states and organization. Using statistical models and computational tools, noncoding regions of DNA can be annotated and combinatorial histone marks inferred. These marks enable the discovery of genomic function and activity, and their patterns change in different cell conditions.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Cell Biology
Pu Xu, Bingyu Zhang, Qing Luo, Guanbin Song
Summary: Early controlled motion has a beneficial effect on tendon healing and function recovery, although the underlying mechanisms remain unclear. This study demonstrated that mechanical stretch can enhance rat tenocyte migration and induce nuclear morphology changes, mainly through chromatin remodeling. These findings contribute to a better understanding of the role of mechanical stretch in tendon repair.
WOUND REPAIR AND REGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Chuizheng Kong, Guangyao Zhao, Lifeng Gao, Xiuying Kong, Daowen Wang, Xu Liu, Jizeng Jia
Summary: In this study, the association between transposons (TEs), chromatin states, and chromatin accessibility in Aegilops tauschii was analyzed. It was found that TEs contributed to the diverse distribution of chromatin states and affected the chromatin state and openness of potential regulatory elements. Some TE superfamilies carried active/open chromatin regions. Furthermore, the accessibility shaped by TEs was associated with the histone mark H3K9ac. These findings highlight the role of TEs in shaping the epigenetic landscape and regulating gene expression in Aegilops tauschii.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shuai Zhao, Kelly N. Chuh, Baichao Zhang, Barbara E. Dul, Robert E. Thompson, Lorna A. Farrelly, Xiaohui Liu, Ning Xu, Yi Xue, Robert G. Roeder, Ian Maze, Tom W. Muir, Haitao Li
Summary: The study found that the readers of H3K4me3 retain binding to H3K4me3Q5ser, while the erasers are significantly inhibited. The results suggest that H3Q5ser may potentially fine-tune critical gene expression programs by stabilizing H3K4me3 from dynamic turnover or enhancing its physical readout by downstream effectors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Liying Wang, Zhiliang Xu, Libin Wang, Chao Liu, Huafang Wei, Ruidan Zhang, Yinghong Chen, Lina Wang, Wenwen Liu, Sai Xiao, Wei Li, Wei Li
Summary: The study reveals that RNF20 is crucial for early stage somatic cell reprogramming, with Rnf20 knockout leading to failure in reprogramming at the initial stage. The absence of RNF20 affects the transcription of MET-related genes and early pluripotency genes, ultimately hindering the establishment of a pluripotent gene network.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Yuexuan Wang, Yu Han, Yuzhen Jin, Qiang He, Zhicheng Wang
Summary: This study discusses the pathogenesis of cancer and the impact of radiotherapy on cancer. It has been found that epigenetic modification plays an important role in the occurrence and development of cancer. Radiation therapy affects the epigenetic modifications of DNA, chromatin, etc., which in turn affects the treatment outcomes. Therefore, studying the interaction between radiotherapy and epigenetic modifications can help us better understand cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
David Corujo, Roberto Malinverni, Juan Carrillo-Reixach, Oliver Meers, Arce Garcia-Jaraquemada, Marguerite-Marie Le Pannerer, Vanesa Valero, Ainhoa Perez, Alvaro Del Rio-Alvarez, Laura Royo, Beatriz Perez-Gonzalez, Helena Raurell, Rafael D. Acemel, Jose M. Santos-Pereira, Marta Garrido-Pontnou, Jose Luis Gomez-Skarmeta, Lorenzo Pasquali, Josep Manye, Carolina Armengol, Marcus Buschbeck
Summary: MacroH2A histone variants play a critical role in gene regulation, particularly in modulating the response of cancer cells to inflammatory signals. They affect the contact frequency between gene promoters and enhancers, and influence enhancer activity.
Review
Plant Sciences
Justin Su, Zhujun Yao, Yixuan Wu, Joohyun Lee, Jeeyon Jeong
Summary: This article mainly introduces the latest understanding of chromatin-based regulation of iron homeostasis in plants, highlighting recent studies in Arabidopsis and rice. Understanding iron homeostasis in plants is crucial as it is relevant to fundamental biological questions, agriculture, biofortification, and human health.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Charlie Keyzor, Benoit Mermaz, Efstathios Trigazis, SoYoung Jo, Jie Song
Summary: The study demonstrates that the chromatin modification H3K27me3 is crucial in Arabidopsis flower development and self-fertility control. The demethylases ELF6 and JMJ13 regulate carpel and stamen growth antagonistically by targeting genes involved in cell elongation and hormone regulation, ultimately balancing between self-pollination and out-crossing in A. thaliana.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Roya Ramezankhani, Roya Solhi, Hamidreza Aboulkheyr Es, Massoud Vosough, Moustapha Hassan
Summary: Gastric adenocarcinoma (GAC) is the third leading cause of cancer-related death worldwide, with a high mortality rate and resistance to treatment protocols due to heterogeneous molecular pathogenesis, making it crucial to discover key etiologic molecular alterations. Epigenetic modifications play a significant role in repressing or activating cancer-related genes and forming new epigenetic signatures, which can impact cancer initiation and progression. Targeting key epigenetic drivers such as MLLs, ARID1A, and EZH2 may potentially attenuate cancer progression in GAC by manipulating the 3D chromatin structure and regulating the expression of tumor suppressor genes and oncogenes.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cell Biology
Thomas Rico, Melissa Gilles, Alban Chauderlier, Thomas Comptdaer, Romain Magnez, Maggy Chwastyniak, Herve Drobecq, Florence Pinet, Xavier Thuru, Luc Buee, Marie-Christine Galas, Bruno Lefebvre
Summary: Recent studies have shown that Tau expression in breast cancer cell lines can confer resistance to histone deacetylase inhibitors by disrupting gene expression and chromatin structure remodeling. Tau is also found to bind to core histones and prevent further histone modifications induced by histone deacetylase inhibitors, suggesting a new role for Tau as a chromatin reader with potential therapeutic implications in neuronal and cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Dongze Li, Li Zhang, Yanqiu He, Tingting Zhou, Xi Cheng, Wei Huang, Yong Xu
Summary: Diabetes is a prevalent global epidemic disease that is influenced by genetic, environmental, and socioeconomic factors. Histone post-translational modifications, specifically methylation and acetylation, play significant roles in the pathophysiological changes associated with diabetes. Recent advancements in mass spectrometry have identified novel histone acylation modifications, which are yet to be thoroughly investigated for their connection to diabetes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Anil Pawar, Maria Russo, Isha Rani, Kalyan Goswami, Gian Luigi Russo, Amit Pal
Summary: The interim results of large trials on COVID-19 using antiviral drugs show little to no effect, leading to a continued search for alternate drugs and supplements. This review highlights the possible efficacy of quercetin in treating and preventing severe acute respiratory syndrome coronavirus and its comorbidities. Multiple clinical trials are currently assessing the efficacy of quercetin and other drugs/supplements for COVID-19. Despite its therapeutic properties, further trials are needed to establish its clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Review
Immunology
Antonietta Liotti, Anne Lise Ferrara, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi, Francesca Di Rella, Giorgia Teresa Maniscalco, Martina Belardo, Roberta Vastano, Rosaria Prencipe, Laura Pignata, Roberta Romano, Giuseppe Spadaro, Paola de Candia, Antonio Pezone, Veronica De Rosa
Summary: Epigenetics connects genetic and environmental factors and controls immune cell fate decisions and functionality. Stable and dynamic epigenetic states play a crucial role in regulating immune cell identity and plasticity.
Article
Biochemistry & Molecular Biology
Maria Russo, Stefania Moccia, Carmela Spagnuolo, Idolo Tedesco, Gian Luigi Russo
Summary: This study demonstrated that carotenoid-enriched nanoemulsions (CEN) can activate a cytostatic form of autophagy and decrease the expression of the senescence marker p16(INK4) in SAOS400 cells. When combined with gamma-irradiation, CEN can induce cytotoxic autophagy and enhance cell death. Beta-carotene, a component of CEN, did not show radiosensitizing effect, suggesting that other bioactive molecules present in CEN may contribute to its biological effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Carmela Spagnuolo, Stefania Moccia, Idolo Tedesco, Giuseppina Crescente, Maria Grazia Volpe, Maria Russo, Gian Luigi Russo
Summary: Regular consumption of olive oil is associated with protection against chronic-degenerative diseases, such as cancer. Epidemiological evidence indicates an inverse association between olive oil intake and bladder cancer risk. We investigated the anti-proliferative effects of a phenolic extract prepared from an extra virgin olive oil (EVOOE) on two human bladder cancer cell lines, and the results suggest that the mixture of phenolic compounds in extra virgin olive oil activates different anti-proliferative pathways.
Article
Oncology
Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo, Carla Reale, Concetta Ambrosino, Claudia Miele, Francesco Beguinot, Vittoria D'Esposito, Pietro Formisano
Summary: This study demonstrates that high glucose levels enhance the aggressiveness of breast cancer cells and promote a pro-tumorigenic phenotype in mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs). The findings suggest that metabolic control may be important for reducing cancer outgrowth and preserving the functions of the adipose microenvironment.
Article
Cell & Tissue Engineering
Alessia Parascandolo, Michele Francesco Di Tolla, Domenico Liguoro, Manuela Lecce, Saverio Misso, Fabiana Micieli, Maria Rosaria Ambrosio, Serena Cabaro, Francesco Beguinot, Alessandra Pelagalli, Vittoria D'Esposito, Pietro Formisano
Summary: Platelet products are commonly used in regenerative medicine for wound healing, reduction of bleeding, tissue synthesis, and revascularization. Human platelet-rich plasma (hPRP) was found to support canine mesenchymal stem cells (cMSCs) by increasing their viability and migration. This study suggests that hPRP may be a promising tool for canine tissue regeneration and repair.
STEM CELLS INTERNATIONAL
(2023)
Article
Oncology
Maria Russo, Stefania Moccia, Diomira Luongo, Gian Luigi Russo
Summary: The role of autophagy and senescence in cancer resistance to ionizing radiation is still not fully understood. This study found that the flavonoids quercetin and fisetin can induce autophagy and senescence-associated inflammatory markers by activating AMPK and inhibiting the ERK pathway. The combined treatment promotes autophagy and senescence induction, lowers the threshold for cell death, and induces apoptosis.
Article
Biochemistry & Molecular Biology
Carmela Spagnuolo, Federica Moccia, Idolo Tedesco, Eva Adabbo, Lucia Panzella, Gian Luigi Russo, Alessandra Napolitano
Summary: The extract obtained from the waste of fermented strawberry distillate production exhibited high antioxidant and antiproliferative properties, mainly attributed to the presence of ellagic acid and p-coumaric acid. It showed strong antiproliferative effects on human cancer cell lines, especially on HL-60 cells, through rapid apoptosis induction. The extract also exhibited antioxidant activity and modulation of cellular oxidative stress and signaling pathways.
Review
Microbiology
Antonio Santaniello, Giuseppe Perruolo, Serena Cristiano, Ayewa Lawoe Agognon, Serena Cabaro, Alessia Amato, Ludovico Dipineto, Luca Borrelli, Pietro Formisano, Alessandro Fioretti, Francesco Oriente
Summary: In March 2020, the World Health Organization declared the COVID-19 outbreak as a global pandemic due to its rapid spread worldwide. This pandemic has not only been a health emergency but also a significant general problem, leading to economic and social activities being put on hold. The review focuses on the clinical manifestations, diagnosis methods, potential transmission risks, and impact on the human-animal relationship.
Article
Food Science & Technology
Deborah Giordano, Angelo Facchiano, Stefania Moccia, Anna Maria Iole Meola, Gian Luigi Russo, Carmela Spagnuolo
Summary: The aryl hydrocarbon receptor (AhR) is an important environmental sensor involved in various cellular processes and plays a key role in conditions such as cancer, inflammation, and aging. This study aims to investigate the inhibitory activity of selected natural compounds on AhR. Through computational modeling and docking simulations, additional binding pockets related to AhR inhibition were discovered. In vitro experiments confirmed the efficacy of beta-carotene and ellagic acid in inhibiting AhR activation, validating the computational approach.
Article
Biochemistry & Molecular Biology
Giulia de Alteriis, Gabriella Pugliese, Antonella Di Sarno, Giovanna Muscogiuri, Luigi Barrea, Valentina Cossiga, Giuseppe Perruolo, Michele Francesco Di Tolla, Francesca Zumbolo, Pietro Formisano, Filomena Morisco, Silvia Savastano
Summary: Visceral obesity is associated with the progression of NASH. CK18 epitopes M30 and M65 are accurate markers for detecting NASH. This study found that CK18M30 and CK18M65 levels were significantly correlated with anthropometric and metabolic characteristics, liver stiffness, and indices of steatosis and fibrosis in subjects with visceral obesity. These levels could serve as good biomarkers for early identification of NASH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Giuseppina Crescente, Giovanni Cascone, Antonio Petruzziello, Aziz Bouymajane, Maria Grazia Volpe, Gian Luigi Russo, Stefania Moccia
Summary: The wine industry generates a significant amount of grape pomace, which is a waste product that needs proper disposal. Two different technologies, microwave hydrodiffusion and gravity (MHG) and ultrasound-assisted extraction (UAE), were used to extract valuable bioactive compounds from grape pomace. The extracts were further purified through solid-phase extraction (SPE) to obtain three fractions, F1, F2, and F3. It was found that F2-MHG and F3-MHG had phenol contents 6.5 and 8.5 times higher than the non-fractionated extracts, respectively.
Article
Chemistry, Medicinal
Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantini
Summary: In Alzheimer's disease, microglia become chronically inflammatory and neurotoxic. Genetic variants of molecules like TREM2 increase the risk of developing AD. This study explored the protective effects of extra virgin olive oil polyphenols on neuronal and microglial cells, finding that they reduce pro-inflammatory cytokines, activate the anti-inflammatory pathway, and enhance microglial activity. These findings offer important insights into the mechanisms by which olive polyphenols alleviate neuroinflammation and neuronal impairment.
Article
Environmental Sciences
Fabiana Franchini, Giuseppe Palatucci, Annamaria Colao, Paola Ungaro, Paolo Emidio Macchia, Immacolata Cristina Nettore
Summary: This article discusses the potential mechanisms linking obesity to thyroid cancer, including chronic inflammation, altered cytokine levels, insulin resistance, oxidative stress, and hormonal changes that occur in obese patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)