The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity

(2015) Elisabeth K. Malle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

Discovery of Molecular Pathways Mediating 1,25-Dihydroxyvitamin D3Protection Against Cytokine-Induced Inflammation and Damage of Human and Male Mouse Islets of Langerhans

(2014) H. Wolden-Kirk et al.   ENDOCRINOLOGY

Noncanonical NF- B Signaling Is Limited by Classical NF- B Activity

(2014) C. M. Gray et al.   Science Signaling

Long-Term IKK2/NF- B Signaling in Pancreatic  -Cells Induces Immune-Mediated Diabetes

(2013) H. H. Salem et al.   DIABETES

SDF-1–CXCR4 differentially regulates autoimmune diabetogenic T cell adhesion through ROBO1–SLIT2 interactions in mice

(2013) John D. Glawe et al.   DIABETOLOGIA

Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD Mouse

(2013) Javier A. Carrero et al.   PLoS One

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

(2012) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation

(2012) G. L. V. de Oliveira et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells

(2012) F. Ortis et al.   FEBS LETTERS

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

The IKK -Dependent NF- B p52/RelB Noncanonical Pathway Is Essential To Sustain a CXCL12 Autocrine Loop in Cells Migrating in Response to HMGB1

(2012) R. R. Kew et al.   JOURNAL OF IMMUNOLOGY

The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells

(2012) Andrea Rückle et al.   JOURNAL OF VIROLOGY

Formononetin Attenuates IL-1β-Induced Apoptosis and NF-κB Activation in INS-1 Cells

(2012) Yao Wang et al.   MOLECULES

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

(2012) Azadeh Arabi et al.   Nature Communications

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction

(2012) Hidefumi Fukushima et al.   Cell Reports

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time

(2010) Antonios Chatzigeorgiou et al.   ANNALS OF MEDICINE

Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer

(2010) Mizuki Yamamoto et al.   CANCER SCIENCE

A single NFκB system for both canonical and non-canonical signaling

(2010) Vincent Feng-Sheng Shih et al.   CELL RESEARCH

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

(2010) Kuppusamy Balamurugan et al.   EMBO JOURNAL

CD4+CD25+ Regulatory T Cells Prevent Type 1 Diabetes Preceded by Dendritic Cell-Dominant Invasive Insulitis by Affecting Chemotaxis and Local Invasiveness of Dendritic Cells

(2010) M.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Innate immunity and the pathogenesis of type 1 diabetes

(2010) Fabio Arturo Grieco et al.   Seminars in Immunopathology

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

(2008) F. Ortis et al.   DIABETOLOGIA