Review
Cell Biology
Filipa Rijo-Ferreira, Joseph S. Takahashi
Summary: Many organisms have evolved timekeeping mechanisms to optimize cellular functions and anticipate environmental changes. Recent research has focused on the interactions between hosts and microbes, with a specific emphasis on how circadian clocks modulate these interactions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Natasha Morales-Ghinaglia, Fan He, Susan L. Calhoun, Alexandros N. Vgontzas, Jason Liao, Duanping Liao, Edward O. Bixler, Julio Fernandez-Mendoza
Summary: Delays and deviations in sleep timing were found to modify the association between adipose tissue and metabolic syndrome in adolescents.
Review
Medicine, Research & Experimental
Zhimei Peng, Yanting Liang, Xueying Liu, Jie Shao, Nan Hu, Xinzhou Zhang
Summary: This review discusses the clinical relevance of circadian rhythms in diabetic kidney disease (DKD) and the functions of the core clock gene BMAL1 in DKD. It also explores the potential mechanisms of Bmal1 and its signaling pathways in DKD, as well as outlines potential intervention strategies for DKD circadian rhythm disturbance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Behavioral Sciences
Jacob R. Bumgarner, William H. Walker, Randy J. Nelson
Summary: The circadian rhythms of pain are not produced by a single locus, but are a complex result of distributed rhythms throughout the pain system and interacting systems, including the opioid, endocrine, and immune systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Sofia Mauri, Mariavittoria Favaro, Greta Bernardo, Gabriella M. M. Mazzotta, Elena Ziviani
Summary: Mitochondrial quality control is crucial for maintaining a healthy mitochondrial pool, with mitophagy playing an important role. Recent studies have questioned the physiological relevance of the PINK1/Parkin pathway in mitophagy and identified other pathways that are independent of these core components. Additionally, the circadian clock has been found to regulate mitochondrial physiology and may play a role in the regulation of mitophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Rinkoo Dalan, Stefan R. Bornstein, Bernhard O. Boehm
Summary: This article discusses the significant advancements in medicine and healthcare in the 21st century Digital Age, primarily driven by the application of data technologies and artificial intelligence. A short story is shared to depict the future state for Cushing's Disease patients and the proposed diagnostic and management approaches. The article postulates a complete reinvention of endocrinology care in the Digital Age.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Paula M. Wagner, Cesar G. Prucca, Beatriz L. Caputto, Mario E. Guido
Summary: Gliomas are solid tumors of the central nervous system classified into four groups by malignancy, with GBM being the most common and aggressive type. Current therapies for GBM have limited efficacy, prompting exploration of the potential role of the circadian clock in tumor cell modulation as a new target for novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Infectious Diseases
Jose-Ramon Blanco, Eva M. Verdugo-Sivianes, Ana Amiama, Sandra Munoz-Galvan
Summary: Circadian genes have an impact on hormonal, metabolic, and immunological pathways and are implicated in some infectious diseases. Understanding the mechanisms linking circadian rhythms and viral infections is important for personalized precision medicine.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Multidisciplinary Sciences
Zoe L. Grange, Tracey Goldstein, Christine K. Johnson, Simon Anthony, Kirsten Gilardi, Peter Daszak, Kevin J. Olival, Tammie O'Rourke, Suzan Murray, Sarah H. Olson, Eri Togami, Gema Vidal, Expert Panel, Jonna A. K. Mazet
Summary: This study used expert opinions and scientific evidence to identify risk factors contributing to zoonotic virus spillover and spread, developing a framework and interactive tool to assess the potential risk of wildlife-origin viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
Giulia Quaglia, Giulia Mescolini, Elena Catelli, Giacomo Berto, Filippo Muccioli, Caterina Lupini
Summary: Chicken Infectious Anemia Virus (CIAV) is an immunosuppressive pathogen of chickens, with strains circulating in different types of chicken flocks. The study in Italy revealed the molecular characteristics of CIAVs, showing highly heterogeneous strains and a worldwide distribution map of field viruses. Non-invasive samples such as feathers and environmental dust were successfully used for DNA amplification, with strains clustered into various genogroups with genetic markers related to virulence evaluated.
Review
Cardiac & Cardiovascular Systems
Mariana G. Figueiro, David Pedler
Summary: The advent of electric lighting has greatly changed human perception of light and darkness, but it often fails to stimulate and synchronize the circadian system. This can lead to poor sleep and may contribute to the increased incidence of cardiovascular diseases. This contribution suggests incorporating daily exposures to light and darkness as lifestyle factors to reduce the risk and progression of cardiovascular diseases.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Multidisciplinary Sciences
Fuyuki Asano, Staci J. Kim, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Nodoka Asama, Kanako Iwasaki, Miyo Kakizaki, Seiya Mizuno, Michihiro Mieda, Fumihiro Sugiyama, Satoru Takahashi, Shoi Shi, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa
Summary: Deficiency of SIK3 in GABAergic neurons or NMS-producing neurons delays the arousal peak phase, while a gain-of-function mutant allele of Sik3 in GABAergic neurons advances the activity onset. Furthermore, HDAC4 deficiency shortens the circadian cycle.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Soo Ji Kim, Chris Chi, Gopal Pattanayak, Aaron R. Dinner, Michael J. Rust
Summary: By studying the cyanobacterial clock, a new protein called KidA was discovered to interact with the clock and shorten its period. It was also found that KidA alters the clock's ability to entrain to light-dark cycles. These findings reveal that the period and amplitude of the clock can be modulated by regulating the access of KaiB to the fold-switched form.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Kelsie M. M. Full, Tianyi Huang, Neomi A. A. Shah, Matthew A. A. Allison, Erin D. D. Michos, Daniel A. A. Duprez, Susan Redline, Pamela L. L. Lutsey
Summary: This study examined the association between sleep regularity and subclinical atherosclerosis. The results showed that irregular sleep duration and sleep timing were associated with early-stage atherosclerosis. Participants with greater sleep duration irregularity and irregular sleep timing were more likely to have high coronary artery calcium burden and abnormal ankle-brachial index.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Public, Environmental & Occupational Health
Michail Katsoulis, Bianca De Stavola, Alvina G. Lai, Manuel Gomes, Karla Diaz-Ordaz
Article
Pharmacology & Pharmacy
Tingting Chen, Zhimin Ma, Zhenwen Qiu, Zhong Zhong, Lei Xing, Qiuping Guo, Dandong Luo, Zhiwei Weng, Fucheng Ge, Yating Huang, Xiubing Zhang, Hongling He, Xiaodong Zhuang, Qingguo Li, Tianhui Yuan
Summary: In this study, the impact of excipients on the pharmaceutical properties of sirolimus in the SAS-FB process was evaluated. Co-precipitation of excipients and sirolimus was found to affect the specific surface area of the carrier and drug yield. Among the tested excipients, the formulation containing polyvinylpyrrolidone K30 showed the highest drug yield and significantly improved oral bioavailability compared to the Rapamune tablet. Characterization of the processed API was conducted to understand the mechanism by which excipients contributed to drug dissolution properties.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Immunology
Yanchun Peng, Suet Ling Felce, Danning Dong, Frank Penkava, Alexander J. Mentzer, Xuan Yao, Guihai Liu, Zixi Yin, Ji-Li Chen, Yongxu Lu, Dannielle Wellington, Peter A. C. Wing, Delaney C. C. Dominey-Foy, Chen Jin, Wenbo Wang, Megat Abd Hamid, Ricardo A. Fernandes, Beibei Wang, Anastasia Fries, Xiaodong Zhuang, Neil Ashley, Timothy Rostron, Craig Waugh, Paul Sopp, Philip Hublitz, Ryan Beveridge, Tiong Kit Tan, Christina Dold, Andrew J. Kwok, Charlotte Rich-Griffin, Wanwisa Dejnirattisa, Chang Liu, Prathiba Kurupati, Isar Nassiri, Robert A. Watson, Orion Tong, Chelsea A. Taylor, Piyush Kumar Sharma, Bo Sun, Fabiola Curion, Santiago Revale, Lucy C. Garner, Kathrin Jansen, Ricardo C. Ferreira, Moustafa Attar, Jeremy W. Fry, Rebecca A. Russell, Hans J. Stauss, William James, Alain Townsend, Ling-Pei Ho, Paul Klenerman, Juthathip Mongkolsapaya, Gavin R. Screaton, Calliope Dendrou, Stephen N. Sansom, Rachael Bashford-Rogers, Benny Chain, Geoffrey L. Smith, Jane A. McKeating, Benjamin P. Fairfax, Paul Bowness, Andrew J. McMichael, Graham Ogg, Julian C. Knight, Tao Dong
Summary: Specific CD8(+) T cell responses targeting NP105-113-B*07:02 are associated with mild COVID-19 disease and high antiviral efficacy, providing potential targets for T cell vaccine design. These T cell responses show long-lasting preservation of antiviral functionality post-infection.
Article
Virology
Xiaodong Zhuang, Wei Wang, Helene Borrmann, Peter Balfe, Philippa C. Matthews, David W. Eyre, Elizabeth B. Klerman, Jane A. McKeating
Summary: This study investigates the variation of COVID-19 viral load at different time points and in different populations. The results reveal a higher viral load in samples obtained in the afternoon, in males, and in hospitalized patients. This study emphasizes the importance of recording sample collection times when measuring viral replication parameters.
Article
Cardiac & Cardiovascular Systems
Sheng-Chia Chung, Alvina Lai, Gregory Y. H. Lip, Pier D. Lambiase, Rui Providencia
Summary: Using real-world data from the UK, this study aimed to investigate the effectiveness of anti-arrhythmic drugs and catheter ablation in improving the survival of atrial fibrillation patients. The study found that patients receiving rhythm control treatment had lower mortality rates, with pulmonary vein isolation showing the most pronounced survival benefit.
Article
Genetics & Heredity
Stefanie H. Mueller, Alvina G. Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U. Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Thais Baert, Laura E. Beane Freeman, Matthias W. Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia Bogdanova, Stig E. Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y. Brucker, Saundra S. Buys, Jose E. Castelao, Tsun L. Chan, Jenny Chang-Claude, Stephen J. Chanock, Ji-Yeob Choi, Wendy K. Chung, Sarah Colonna, Sten Cornelissen, Fergus J. Couch, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Laure Dossus, Miriam Dwek, Diana M. Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Olivia Fletcher, Henrik Flyger, Manuela Gago-Dominguez, Yu-Tang Gao, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Jeanine Genkinger, Aleksandra Gentry-Maharaj, Felix Grassmann, Pascal Guenel, Melanie Gundert, Lothar Haeberle, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Elaine F. Harkness, Patricia A. Harrington, Jaana M. Hartikainen, Mikael Hartman, Alexander Hein, Weang-Kee Ho, Maartje J. Hooning, Reiner Hoppe, John L. Hopper, Richard S. Houlston, Anthony Howell, David J. Hunter, Dezheng Huo, Abctb Investigators, Hidemi Ito, Motoki Iwasaki, Anna Jakubowska, Wolfgang Janni, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Daehee Kang, Elza K. Khusnutdinova, Sung-Won Kim, Cari M. Kitahara, Stella Koutros, Peter Kraft, Vessela N. Kristensen, Katerina Kubelka-Sabit, Allison W. Kurian, Ava Kwong, James Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Martha Linet, Wing-Yee Lo, Jirong Long, Artitaya Lophatananon, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Keitaro Matsuo, Dimitrios Mavroudis, Usha Menon, Kenneth Muir, Rachel A. Murphy, Heli Nevanlinna, William G. Newman, Dieter Niederacher, Katie M. O'Brien, Nadia Obi, Kenneth Offit, Olufunmilayo Olopade, Andrew F. Olshan, Hakan Olsson, Sue K. Park, Alpa Patel, Achal Patel, Charles M. Perou, Julian Peto, Paul D. P. Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Brigitte Rack, Paolo Radice, Dhanya Ramachandran, Muhammad U. Rashid, Gad Rennert, Atocha Romero, Kathryn J. Ruddy, Matthias Ruebner, Emmanouil Saloustros, Dale P. Sandler, Elinor J. Sawyer, Marjanka K. Schmidt, Rita K. Schmutzler, Michael O. Schneider, Christopher Scott, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xiao-Ou Shu, Jacques Simard, Harald Surowy, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Soo Hwang Teo, Lauren R. Teras, Amanda E. Toland, Rob A. E. M. Tollenaar, Diana Torres, Gabriela Torres-Mejia, Melissa A. Troester, Therese Truong, Celine M. Vachon, Joseph Vijai, Clarice R. Weinberg, Camilla Wendt, Robert Winqvist, Alicja Wolk, Anna H. Wu, Taiki Yamaji, Xiaohong R. Yang, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Elad Ziv, Alison M. Dunning, Douglas F. Easton, Harry Hemingway, Ute Hamann, Karoline B. Kuchenbaecker
Summary: This study identified 14 genes associated with breast cancer using gene-based aggregation analysis, including two newly discovered genes FMNL3 and AC058822.1. Furthermore, associations with established candidate genes like ESR1 were found through the collaboration of multi-ancestral cohorts, highlighting the importance of diversifying study cohorts. These findings provide new insights into the development of breast cancer.
Article
Biochemistry & Molecular Biology
Holly Simpson Ragdale, Melanie Clements, Wenhao Tang, Elitza Deltcheva, Catia Andreassi, Alvina G. Lai, Wai Hoong Chang, Maria Pandrea, Ivan Andrew, Laurence Game, Imran Uddin, Michael Ellis, Tariq Enver, Antonella Riccio, Samuel Marguerat, Simona Parrinello
Summary: Most normal parenchymal astrocytes are unable to dedifferentiate to neural stem cells after injury, while aberrant lineage plasticity is a characteristic of gliomas. In this study, it was found that p53 loss destabilizes the identity of astrocytes, making them more prone to dedifferentiation. This is caused by persistent neuroinflammation and EGFR activation, and involves the upregulation of mTOR signaling downstream of p53 loss and EGFR.
Article
Multidisciplinary Sciences
Wai Hoong Chang, Richard D. Neal, Martin D. Forster, Alvina G. Lai
Summary: This study evaluated the burden of 144 health conditions and critical care admissions in 243,767 adults with 26 adult cancers and treatment modalities. The top conditions by fold difference in cumulative burden in survivors compared to controls were haematology, immunology/infection, and pulmonary conditions. Patients receiving chemotherapy, radiotherapy, and surgery had a higher burden of late morbidities compared to those receiving radiotherapy alone. The top five cancers with the highest cumulative burden of critical care admissions were bone, brain, spinal cord and nervous system, testis, and Hodgkin lymphoma.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Helene Borrmann, Dini Ismed, Anna E. Kliszczak, Persephone Borrow, Sridhar Vasudevan, Aarti Jagannath, Xiaodong Zhuang, Jane A. McKeating
Summary: Human immunodeficiency virus type 1 (HIV-1) poses a significant global health burden, and eradicating latent virus infection is a major challenge. The circadian clock, an internal timing system, regulates HIV-1 replication. Salt inducible kinases (SIK) contribute to this regulation, and inhibiting SIKs disrupts the cellular clock and reduces rhythmic HIV-1 replication. This study demonstrates the role of SIKs in regulating HIV-1 replication and latency reactivation, providing insights for understanding and targeting latent HIV-1 infection.
JOURNAL OF GENERAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Harrison Wilde, Christopher Tomlinson, Bilal A. Mateen, David Selby, Hari Krishnan Kanthimathinathan, Padmanabhan Ramnarayan, Pascale Du Pre, Mae Johnson, Nazima Pathan, Arturo Gonzalez-Izquierdo, Alvina G. Lai, Deepti Gurdasani, Christina Pagel, Spiros Denaxas, Sebastian Vollmer, Katherine Brown
Summary: This cohort study examined hospital admissions associated with SARS-CoV-2 infection in children and adolescents in England. The results showed that most admissions were due to SARS-CoV-2 or SARS-CoV-2 was a contributory factor. Boys, younger children, and those from ethnic minority groups or areas of high deprivation were more likely to be admitted to hospital. These findings have implications for public health initiatives and further research.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Geriatrics & Gerontology
Yen Yi Tan, Vaclav Papez, Wai Hoong Chang, Stefanie H. Mueller, Spiros Denaxas, Alvina G. Lai
Summary: The study shows that vulnerable populations are often excluded from clinical trials (RCTs), leading to incomplete real-world clinical decision information. Investigations reveal that many vulnerable individuals receiving prescription drug treatment in clinical practice are commonly excluded from RCTs, which may result in a lack of relevant treatment information. Observational studies can effectively complement the shortcomings of RCTs to provide patients with more comprehensive information on treatment risks and benefits.
LANCET HEALTHY LONGEVITY
(2022)
Article
Health Care Sciences & Services
Sheng-Chia Chung, Stefanie Mueller, Katherine Green, Wai Hoong Chang, Darren Hargrave, Alvina G. Lai
Summary: This study characterized the morbidity patterns in children and compared them between childhood cancer survivors and children without cancer. The findings demonstrate that childhood cancer survivors have a higher prevalence and subsequent risk of hospitalization for various morbidities.
LANCET REGIONAL HEALTH-EUROPE
(2022)
Article
Health Care Sciences & Services
Wai Hoong Chang, Michail Katsoulis, Yen Yi Tan, Stefanie H. Mueller, Katherine Green, Alvina G. Lai
Summary: The study aims to systematically quantify the cumulative burden of late effects among cancer survivors and investigate the association between treatment exposures and late effects using linked electronic health records. The findings reveal that different cancer types and treatment modalities are associated with varying late effects burdens and risks of premature mortality.
LANCET REGIONAL HEALTH-EUROPE
(2022)
Article
Medical Informatics
Johan H. Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad A. Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina G. Lai, Kezhi Li, Bilal A. Mateen, Naveed Sattar, Reecha Sofat, Ana Torralbo, Honghan Wu, Angela Wood, Jonathan A. C. Sterne, Christina Pagel, William N. Whiteley, Cathie Sudlow, Harry Hemingway, Spiros Denaxas
Summary: This study used nationwide linked electronic health records to define and validate ten COVID-19 phenotypes, providing insights into the different stages and transitions of the disease. The results showed infection rates, hospitalization rates, intensive care unit usage, and mortality rates of COVID-19. Longer patient trajectories were observed in the second wave compared to the first wave.
LANCET DIGITAL HEALTH
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Atish Mukherji, Frank Juhling, Laurent Mailly, Carla Eller, Katharina Herzog, Cloe Gadenne, Clara Ponsolles, Alexandre Haller, Philippe Baltzinger, Hiroshi Aikata, Michio Imamura, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Jane McKeating, Irwin Davidson, Patrick Pessaux, Joachim Lupberger, Thomas Baumert
JOURNAL OF HEPATOLOGY
(2022)
