Review
Endocrinology & Metabolism
Josie L. Fullerton, Josephine M. Thomas, Laura Gonzalez-Trueba, Cara Trivett, Josie C. van Kralingen, Stuart M. Allan, Terence J. Quinn, Lorraine M. Work
Summary: This systematic review aimed to assess the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs and their use in the diagnosis and prognosis of ischaemic or haemorrhagic stroke. The findings highlighted specific microRNAs that consistently showed differential expression in both clinical and preclinical samples following stroke. However, further studies with larger populations and consistent methodologies are needed to confirm the clinical value of circulating microRNAs as biomarkers for stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Medical Laboratory Technology
Yudong Wu, Qian Li, Renshuai Zhang, Xiaoli Dai, Wujun Chen, Dongming Xing
Summary: MicroRNAs, approximately 20-24 nucleotides in length, are considered reliable diagnostic and prognostic biomarkers for various diseases due to their reflection of disease progression and drug resistance. They play a crucial role in the diagnosis, prognosis, and treatment response prediction of diseases, potentially improving cure rates.
CLINICA CHIMICA ACTA
(2021)
Review
Oncology
Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos, Carla Martins Kaneto
Summary: Cervical cancer is a preventable disease but remains a significant public health problem. The Pap smear has achieved great success, but has limitations, leading to the need for new approaches for early diagnosis and biomarker discovery. miRNAs have been identified as non-invasive biomarkers and have potential clinical value for early-stage cervical intraepithelial neoplasia screening. This study reviewed the expression of circulating miRNAs in the development of cervical cancer and identified potential biomarkers.
Review
Urology & Nephrology
Ricardo Leao, Maarten Albersen, Leendert H. J. Looijenga, Torgrim Tandstad, Christian Kollmannsberger, Matthew J. Murray, Stephane Culine, Nicholas Coleman, Gazanfer Belge, Robert J. Hamilton, Klaus-Peter Dieckmann
Summary: Circulating microRNA levels, especially miR-371a-3p, show promise for clinical use in testicular germ cell tumors, with high sensitivity and specificity in various clinical scenarios, potentially aiding in clinical decision-making.
Article
Endocrinology & Metabolism
Isaac Snowhite, Ricardo Pastori, Jay Sosenko, Shari Messinger Cayetano, Alberto Pugliese
Summary: The study found that baseline miRNA levels can predict the severity of future decline in insulin secretion in type 1 diabetes patients, providing a new predictive marker for stratifying subjects in clinical trials.
Review
Biochemistry & Molecular Biology
Codrin-Constantin Burlacu, Daniela Ciobanu, Andrei-Vlad Badulescu, Vlad-Florin Chelaru, Andrei-Otto Mitre, Bogdan Capitanescu, Dirk M. Hermann, Aurel Popa-Wagner
Summary: Stroke is the second leading cause of death and disability, with limited therapeutic strategies. Blood-based biomarkers, such as microRNAs and exosomes, are recognized as useful tools to predict prognosis in patients with stroke. This systematic review identified 72 circulating biomarkers with prognostic value in stroke recovery, including 68 miRNAs predictive for motor recovery and seven biomarkers predictive for cognitive recovery. The most significant correlations were found with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. Serum miR-9 and neutrophil miR-29b were identified as promising biomarkers for further studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Simone Ciuffi, Francesca Marini, Caterina Fossi, Simone Donati, Francesca Giusti, Annalisa Botta, Laura Masi, Giancarlo Isaia, Claudio Marcocci, Silvia Migliaccio, Salvatore Minisola, Ranuccio Nuti, Umberto Tarantino, Teresa Iantomasi, Maria Luisa Brandi
Summary: This study investigated the expression of circulating microRNAs (miRNAs) in osteoporotic patients using next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR). The study identified differentially expressed miRNAs, including miR-23a-3p, miR-21-5p, and miR-320a-3p, which could distinguish osteoporotic patients from individuals with normal bone mineral density (BMD). Increased expression of c-miR-320a-3p was specifically associated with fractures, suggesting it as a potential prognostic indicator of fracture risk in osteoporotic patients. These findings need to be further validated in prospective studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Davida Mirra, Erika Cione, Giuseppe Spaziano, Renata Esposito, Mario Sorgenti, Elisabetta Granato, Ida Cerqua, Lucia Muraca, Pasquale Iovino, Luca Gallelli, Bruno D'Agostino
Summary: This study compares the serum expression of microRNAs between asthmatic patients, obese patients (the most common comorbidity in asthma), and healthy controls, and identifies the specific involvement of microRNAs in the regulation of lung inflammatory response. It highlights the potential of microRNAs as a clinical marker for asthma evaluation and management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Paula Morales-Sanchez, Carmen Lambert, Jessica Ares-Blanco, Lorena Suarez-Gutierrez, Elsa Villa-Fernandez, Ana Victoria Garcia, Miguel Garcia-Villarino, Juan Ramon Tejedor, Mario F. Fraga, Edelmiro Menendez Torre, Pedro Pujante, Elias Delgado
Summary: This study aimed to analyze the circulating miRNA expression profile of patients with type 1 diabetes and no other associated pathology. The expression of hsa-miR-1-3p was found to be significantly increased in patients with type 1 diabetes and positively correlated with glycated haemoglobin levels. Changes in hsa-miR-1-3p were also found to directly affect genes involved in vascular development and cardiovascular pathologies. Circulating hsa-miR-1-3p, along with glycemic control, could be used as prognostic biomarkers in type 1 diabetes to prevent the development of vascular complications in these patients.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Ekua W. Brenu, Mark Harris, Emma E. Hamilton-Williams
Summary: This systematic review evaluates novel circulating biomarkers associated with future progression to type 1 diabetes (T1D). The study found that some circulating biomarkers are dysregulated before T1D diagnosis and may be useful in predicting the risk and rate of progression to T1D. However, further research is needed to validate these biomarkers and assess their predictive accuracy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jody Vykoukal, Johannes F. Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J. Ostrin, Jennifer B. Dennison, Cristina Ivan, Gary E. Goodman, Mark D. Thornquist, Matt J. Barnett, Ziding Feng, George A. Calin, Samir M. Hanash
Summary: Blood-based cancer biomarkers, including miRNA and four protein marker panel, have shown utility in improving the assessment and early detection of lung cancer.
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Grzegorz Procyk, Dominika Klimczak-Tomaniak, Grazyna Sygitowicz, Mariusz Tomaniak
Summary: MicroRNAs play an important role in the regulation of gene expression in cardiovascular diseases (CVD), with miR-126 and miR-223 being of particular interest. Despite numerous studies, there is still no conclusive evidence on the clinical utility of miRNA expression levels. This review critically appraises the association between miRNA expression, cardiovascular risk, and on-treatment platelet reactivity, and provides insights on future developments in the field.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: This article reviews the current research on the correlation between microRNAs (miRNAs) in extracellular bioliquids and subarachnoid hemorrhage (SAH) and its complications. It discusses the potential use of miRNAs as biomarkers in the treatment of SAH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sara Reis Moura, Hugo Abreu, Carla Cunha, Claudia Ribeiro-Machado, Carla Oliveira, Mario Adolfo Barbosa, Herlander Marques, Maria Ines Almeida
Summary: This study examines the expression of circulating microRNAs in multiple myeloma (MM) patients and their correlation with clinicopathological features, including bone lesions. Results suggest that certain miRNAs could serve as potential molecular markers for MM diagnosis, with correlations to disease stage, treatment, and other clinical indicators. Additionally, circulating miRNAs show promise as biomarkers for MM diagnosis and correlate with myeloma bone disease and osteolytic lesions.
Article
Endocrinology & Metabolism
Didier F. Pisani, Olivier Dumortier, Guillaume E. Beranger, Virginie Casamento, Rayane A. Ghandour, Maude Giroud, Nadine Gautier, Thierry Balaguer, Jean-Claude Chambard, Kirsi A. Virtanen, Pirjo Nuutila, Tarja Niemi, Markku Taittonen, Emmanuel Van Obberghen, Charlotte Hinault, Ez-Zoubir Amri
Article
Endocrinology & Metabolism
Olivier Dumortier, Estelle Roger, Didier F. Pisani, Virginie Casamento, Nadine Gautier, Patricia Lebrun, Hereroa Johnston, Pascal Lopez, Ez-Zoubir Amri, Celine Jousse, Pierre Fafournoux, Marc Prentki, Charlotte Hinault, Emmanuel Van Obberghen
Article
Endocrinology & Metabolism
Olivier Dumortier, Charlotte Hinault, Nadine Gautier, Stephanie Patouraux, Virginie Casamento, Emmanuel Van Obberghen
Review
Medicine, Research & Experimental
Charlotte Hinault, Olivier Dumortier, Emmanuel Van Obberghen
M S-MEDECINE SCIENCES
(2013)
Article
Genetics & Heredity
Laurent Bonesso, Monique Piraud, Celine Caruba, Emmanuel Van Obberghen, Raymond Mengual, Charlotte Hinault
ORPHANET JOURNAL OF RARE DISEASES
(2014)
Article
Biochemistry & Molecular Biology
Estelle Roger, Olivier Dumortier, Didier F. Pisani, Nadine Gautier, Emmanuel Van Obberghen, Charlotte Hinault
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Endocrinology & Metabolism
Olivier Dumortier, Gaia Fabris, Didier F. Pisani, Virginie Casamento, Nadine Gautier, Charlotte Hinault, Patricia Lebrun, Christophe Duranton, Michel Tauc, Stephane Dalle, Julie Kerr-Conte, Francois Pattou, Marc Prentki, Emmanuel Van Obberghen
JOURNAL OF ENDOCRINOLOGY
(2020)
Review
Endocrinology & Metabolism
Nicolas Chevalier, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel
Summary: GPER/GPR30, a novel estrogen-binding protein structurally distinct from classic estrogen receptors, is involved in male germ cell proliferation in testicular germ cell cancers. Overexpression of GPER/GPR30 in seminomas, potentially linked to genetic variations, suggests it as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Stephanie Torrino, Victor Tiroille, Bastien Dolfi, Maeva Dufies, Charlotte Hinault, Laurent Bonesso, Sonia Dagnino, Jennifer Uhler, Marie Irondelle, Anne-sophie Gay, Lucile Fleuriot, Delphine Debayle, Sandra Lacas-Gervais, Mireille Cormont, Thomas Bertero, Frederic Bost, Jerome Gilleron, Stephan Clavel
Summary: UBTD1 plays a crucial role in EGFR signaling by controlling both the phosphorylation and lysosomal degradation of EGFR, contributing to the regulation of signal duration.
Review
Endocrinology & Metabolism
Emma Bokobza, Charlotte Hinault, Victor Tiroille, Stephan Clavel, Frederic Bost, Nicolas Chevalier
Summary: Obesity is a significant public health concern associated with increased risk of various cancers, including gastrointestinal tract cancers and hormone-dependent cancers. Adipose tissue plays a crucial role in this process, as it is considered a major internal source of endocrine disrupting chemicals that can impact hormonal balance and cell proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aurelie Charazac, Charlotte Hinault, Bastien Dolfi, Solene Hautier, Celia Deconde Le Butor, Frederic Bost, Nicolas Chevalier
Summary: Endocrine Disrupting Compounds (EDCs) are compounds found in everyday products that can disrupt hormonal effects and have adverse health effects. This study found that four specific EDCs promoted the proliferation of cancer cell lines from hormone-sensitive organs (prostate and breast), with PFOA and PCB153 showing this effect at very low concentrations (10(-12) M).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christian Hubert Roux, Anne-Sophie Rousseau, Antonio Iannelli, Nadine Gautier, Stephanie Ferrero, Charlotte Hinault, Giulia Chinetti, Willy Ngueyon-Sime, Francis Guillemin, Ez Zoubir Amri
Summary: This study aimed to investigate the serum OT level in hip and/or knee OA patients and its association with disease progression. The findings suggest that there is no significant association between OT levels and OA progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Hinault, Philippe Caroli-Bosc, Frederic Bost, Nicolas Chevalier
Summary: Diabetes mellitus is a significant global health problem, impacting individuals and economies. The chronic hyperglycemia associated with diabetes leads to severe complications, including retinopathy, kidney failure, and cardiovascular diseases. While genetic factors and environmental factors like sedentary lifestyles, overweight, and obesity contribute to the development of diabetes, there is growing evidence suggesting the role of endocrine-disrupting chemicals (EDCs) in the pathophysiology of diabetes and metabolic disorders. This narrative review critically examines the impact of EDCs on our endocrine system and their link to diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Nicolas Chevalier, Charlotte Hinault
CORRESPONDANCES EN METABOLISMES HORMONES DIABETES ET NUTRITION
(2018)
