Article
Pharmacology & Pharmacy
Ole Jensen, Johannes Matthaei, Henry G. Klemp, Marleen J. Meyer, Jurgen Brockmoller, Mladen V. Tzvetkov
Summary: This study confirmed IBC as an endogenous biomarker of OCT1 activity in humans, with OCT1 potentially regulating cellular concentrations of specific regulators or co-substrates in lipid and energy metabolism. Unlike in mice, OCT1 in humans may not directly mediate the efflux of IBC, suggesting a different mechanism for the association between blood concentrations of carnitine derivatives and OCT1 genotype in humans.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yenju Chu, Abigail Wong, Haojie Chen, Liuhang Ji, Chaolong Qin, Wanshan Feng, Michael J. Stocks, Pavel Gershkovich
Summary: A military helicopter crash in Vietnam resulted in 13 deaths and 3 injuries. The cause of the accident is under investigation.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Akula S. N. Murthy, Sanket Das, Tejinder Singh, Tae-Wan Kim, Nasim Sepay, Seob Jeon, Jungkyun Im
Summary: Delivering cytotoxic drugs, antioxidants, and imaging molecules to mitochondria provides new therapeutic opportunities. The addition of a lipophilic group enhances the targeting ability of molecular transporters to mitochondria, and they can form ionic complexes with antibiotics for drug delivery.
Article
Toxicology
Zheng Jing, Hironao Okubo, Jun-ichi Morishige, Pingping Xu, Nazmul Hasan, Naoto Nagata, Hitoshi Ando
Summary: This study reveals the detrimental effects of lenvatinib on OCTN2 expression, carnitine content, and mitochondrial function in skeletal muscle which may be associated with muscle toxicity.
TOXICOLOGY LETTERS
(2022)
Review
Pharmacology & Pharmacy
Christoph Wenzel, Marek Drozdzik, Stefan Oswald
Summary: Intestinal transporter proteins play a crucial role in the pharmacokinetics and efficacy/safety of orally administered drugs, particularly ATP-binding cassette transporters. While information on intestinal uptake carriers is limited, recent studies suggest organic cation transporter 1 may function as an elimination pathway for cationic compounds in the human intestine.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Abhishek Pawar, Swati Korake, Atmaram Pawar, Ravindra Kamble
Summary: The mitochondria, as a vital organelle, plays a significant role in cancer therapy. By attaching mitochondrial-targeting moieties to chemotherapeutics, fluorescent dyes, and photothermal molecules, the anticancer effect can be greatly enhanced. Triphenyl phosphonium (TPP) is the most widely used mitochondrial targeting conjugate, with amplified therapeutic outcomes in the treatment of various cancers.
CURRENT DRUG DELIVERY
(2023)
Review
Endocrinology & Metabolism
Loek L. Crefcoeur, Gepke Visser, Sacha Ferdinandusse, Frits A. Wijburg, Mirjam Langeveld, Barbara Sjouke
Summary: Symptoms in PCD mainly develop in early childhood, with most patients detected through newborn screening remaining asymptomatic, though severe complications can rarely occur in both groups.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Chemistry, Applied
Zhen Zeng, Siqi Deng, Yang Liu, Cheng Li, Zhengfeng Fang, Bin Hu, Hong Chen, Caixia Wang, Saiyan Chen, Wenjuan Wu, Yuntao Liu
Summary: This study prepared a stabilized emulsion using soybean lipophilic protein nanoparticles (SLP-NPs) as a delivery system for curcumin, addressing the limitations of poor solubility and low bioaccessibility. The results showed that the concentration of SLP-NPs had significant effects on the emulsion's droplet size, zeta potential, and microstructure. SLP-NPs were able to encapsulate curcumin with an encapsulation rate of 77.13%, and the stability experiment demonstrated good storage stability. In vitro digestion assay revealed that SLP-NPs increased the bioaccessibility of curcumin by 76.14% and allowed for targeted release in the small intestine. Furthermore, in vivo experiments showed that Cur-SLP regulated the gut microorganism of mice, increasing the abundance of health-promoting bacteria (Bifidobacterium) and significantly reducing the proportion of Firmicutes/Bacteroidetes.
FOOD HYDROCOLLOIDS
(2023)
Article
Pharmacology & Pharmacy
Xiaoxing Wang, Vivek Purohit, Martin E. Dowty, David Rodrigues, Lina Luo, Sumathy Mathialagan, William Carey, Anna Plotka, Hindu Kalluru, O'Gorman Melissa, Julia Kaplan, Yeamin Huh, Manoli Vourvahis, Robert M. Wolk
Summary: Ritlecitinib has been developed as a potential treatment for inflammatory diseases and has been shown to inhibit OCT1, but not OCT2 or MATE1/2K, based on clinical interaction studies.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Antonio J. Lopez Quinones, Leticia Salvador Vieira, Joanne Wang
Summary: This article focuses on the clinical applications of mIBG in neuroendocrine cancers and the differential roles of NET, OCT, and MATE transporters in mIBG disposition, response, and toxicity. Understanding the molecular mechanisms governing mIBG transport in cancer and normal cells is a critical step for developing strategies to optimize the efficacy of 131I-mIBG while minimizing toxicity in normal tissues.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Chemistry, Medicinal
Qikun Jiang, Qiuchi Xu, Yingli Wang, Pengyan Li, Yunran Zhang, Yongjun Wang, Jin Sun, Tianhong Zhang, Zhonggui He
Summary: By modulating the chirality of the linear dipeptide HS-tLL, the colon-targeting efficiency can be enhanced, providing a potential treatment for inflammatory bowel disease (IBD).
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Sook Wah Yee, Kathleen M. Giacomini
Summary: The SLC22 family consists of membrane proteins that play important roles in the transport of solutes. They are involved in the absorption and disposition of prescription drugs, and mutations in some members can lead to rare monogenic disorders. Genetic polymorphisms in SLC22 transporters are associated with common human diseases and drug response. Three new members have recently been identified and their physiological and pharmacological roles need further investigation.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Nanoscience & Nanotechnology
Xinping Hu, Chuhang Zhou, Leqi Wang, Qi Liu, Yining Ma, Yingwei Tang, Xiaoxiao Wang, Kanghao Chen, Xinyu Wang, Yan Liu
Summary: In this study, procedurally targeting nanomicelles were designed for oral delivery of antitumor drugs. The nanomicelles exhibited favorable stability and release capability, and significantly enhanced cellular uptake and transmembrane transport, leading to improved antitumor efficacy.
ACS APPLIED BIO MATERIALS
(2023)
Article
Medicine, Research & Experimental
Huiming Guo, Jianyuan Gao, Yuan Qian, Huawei Wang, Jiang Liu, Qingyan Peng, Yong Zhou, Kunhua Wang
Summary: miR-125b-5p accelerates LPS-induced intestinal mucosa cell injury by targeting ASCT2 and upregulating the PI3K/AKT/mTOR pathway, providing potential novel targets for the treatment of intestinal barrier injury in patients with AIDS.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Mahesh R. Nepal, Hanieh Taheri, Yang Li, Zahra Talebi, Muhammad Erfan Uddin, Yan Jin, Duncan F. DiGiacomo, Alice A. Gibson, Maryam B. Lustberg, Shuiying Hu, Alex Sparreboom
Summary: Duloxetine has been found to inhibit OCT2 and prevent OIPN without compromising the pharmacokinetics and antitumor properties of oxaliplatin, suggesting its potential as a therapeutic candidate for preventing OIPN.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Fujun Yang, Qingyu Ji, Rui Liao, Shumeng Li, Yuequan Wang, Xuanbo Zhang, Shenwu Zhang, Haotian Zhang, Qiming Kan, Jin Sun, Zhonggui He, Bingjun Sun, Cong Luo
Summary: This study presents a facile dual-drug nanoassembly that enhances the efficacy of photodynamic therapy by inhibiting the proteasome. The engineered nanoassembly demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment, and favorable stability and enrichment.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Medicinal
Qikun Jiang, Qiuchi Xu, Yingli Wang, Pengyan Li, Yunran Zhang, Yongjun Wang, Jin Sun, Tianhong Zhang, Zhonggui He
Summary: By modulating the chirality of the linear dipeptide HS-tLL, the colon-targeting efficiency can be enhanced, providing a potential treatment for inflammatory bowel disease (IBD).
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yinxian Yang, Shiyi Zuo, Jingxuan Zhang, Tian Liu, Ximu Li, Haotian Zhang, Maosheng Cheng, Shujun Wang, Zhonggui He, Bingjun Sun, Jin Sun
Summary: This study investigates the effects of sulfur bonds on prodrug nanoassemblies. It reveals that sulfur bonds significantly alter the molecular assembly of prodrugs, thereby influencing their colloidal stability and in vivo fate. Trisulfide bond is identified as a novel redox dual-sensitive linkage.
Article
Engineering, Biomedical
Yixin Sun, Simeng Wang, Yaqi Li, Danping Wang, Yu Zhang, Haotian Zhang, Hongrui Lei, Xiaohong Liu, Jin Sun, Bingjun Sun, Zhonggui He
Summary: Prodrug-based nanoassemblies, combining prodrug technology and nanocarriers, show great promise in cancer treatment. The chemical structure of prodrugs is closely related to their antitumor efficacy and safety, and the relationship between them needs further exploration.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Jiulong Su, Bo Zhu, Akihito Inoue, Hiroyuki Oyama, Izumi Morita, Jinhua Dong, Takanobu Yasuda, Yoshiko Sugita-Konishi, Tetsuya Kitaguchi, Norihiro Kobayashi, Shiro Miyake, Hiroshi Ueda
Summary: Patrol Yeast is a novel yeast-based immunosensor that can detect toxic substances in food. A membrane-based yeast two-hybrid system using split-ubiquitin was used to successfully detect important concentrations of caffeine and aflatoxins. Additionally, it can detect enterohemorrhagic Escherichia coli.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Lanlan Wang, Jinhua Dong, Ziqiang Zhao, Dawei Li, Wenhao Dong, Yingke Lu, Bingqi Jin, Haoxuan Li, Qingsheng Liu, Bingyao Deng
Summary: Antibiotic abuse has become a burden on patients and healthcare systems, leading to a need for non-antibiotic wound dressings. However, hydrogel wound dressings with good recoverability, toughness, and excellent antibacterial properties still face obstacles. In this study, a series of semi-interpenetrating network (semi-IPN) hydrogels were developed using quaternized chitosan (QCS) and polyacrylamide (PAM) through a one-pot method, which showed exceptional mechanical performance and remarkable antibacterial activity. The integration of quercetin (QT) further enhanced the antibacterial properties against S. aureus and E. coli. These high-elastic hydrogels have potential applications in wound dressing, tissue repair, chronic wound care, and other biomedical fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Chutong Tian, Jin Sun, Mingyang Zhang, Chunlin Guo, Yifan Miao, Zhonggui He
Summary: In this study, a lipophilic disulfide-bridged linoleic prodrug (PTX-S-S-LA) was synthesized and efficiently incorporated into a self-microemulsifying drug delivery system (SMEDDS) to facilitate the oral absorption of paclitaxel (PTX). The prodrug SMEDDS showed higher drug loading efficiency and stability compared to parent PTX, and significantly increased drug partition in the intestinal micellar aqueous phase. Moreover, SMEDDS enhanced gastrointestinal biological adhesion and lymphatic transport, resulting in improved antitumor efficiency without significant gastrointestinal toxicity. Overall, the combination of PTX-S-S-LA and SMEDDS provides a promising approach for effective oral delivery of PTX.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Xiaoyuan Fan, Kaiyuan Wang, Qi Lu, Yutong Lu, Jin Sun
Summary: Immunotherapy aims to activate the immune system to treat cancer, but its effectiveness in clinical applications is still limited. Cell-based drug delivery systems have the potential to enhance the efficacy of cancer immunotherapy and play important roles.
Article
Nanoscience & Nanotechnology
Lanlan Wang, Ziqiang Zhao, Jinhua Dong, Dawei Li, Wenhao Dong, Haoxuan Li, Yuqi Zhou, Qingsheng Liu, Bingyao Deng
Summary: Multifunctional hydrogel wound dressings with high adhesive, self-healing, antioxidant, and antibacterial activity were designed and fabricated for treating skin injuries in clinical care.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemical Research Methods
Yujie Gao, Shuyang Zhao, Ruxue Zhang, Haimei Li, Mei Li, Bowen Yu, Jinhua Dong
Summary: In this study, a fluorescent immunosensor called Quenchbody (Q-body) was developed for real-time monitoring of FLAG-fused protein expression. Detection results showed that the Q-body had a low limit of detection for the 3 x FLAG peptide and could be used to detect different proteins with a FLAG-tag. Furthermore, the Q-body was used to monitor the real-time fermentation process of a single-strand DNA-binding protein in Escherichia coli. Due to its excellent detection speed and sensitivity, the FLAG Q-body immunosensor has the potential to quantify and monitor target recombinant proteins in multiple biological processes in real-time.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Computer Science, Information Systems
Yuanyuan Liang, Yanbing Ju, Peiwu Dong, Xiao-Jun Zeng, Luis Martinez, Jinhua Dong, Aihua Wang
Summary: This paper proposes a novel LSGDM consensus model that explores and manages the meso-scale structure among experts using free texts in a social network setting. The model extracts preferences over alternatives from experts' opinions through sentiment analysis and converts them into distributed linguistic preference relation matrices. It also introduces a core-periphery detection method for the social network and derives expert weights based on an optimization model that maximizes expert reliability. Additionally, a two-stage consensus model based on prospect theory is developed to improve group consensus systematically and gradually.
INFORMATION SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ximing Zhang, Fangxue Zhao, Jing Feng, Cong Chen, Zhonggui He, Mengchi Sun, Jin Sun
Summary: In this study, an ionizable PTX prodrug (PTXP) was designed to achieve remote loading of liposomal formulations. Compared to marketable PTX liposomes, PTXP liposomes showed higher loading efficiency and encapsulation efficiency, as well as demonstrated stability, prolonged circulation time, high tumor site accumulation, potent anti-tumor effects, and safety in vitro and in vivo.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Jinhua Dong, Bhagat Banwait, Hiroshi Ueda, Peter Kristensen
Summary: Quenchbodies, a type of biosensor, use antibodies labeled with a fluorescent dye to detect proteins. The dye is quenched in the absence of an antigen, but de-quenched in its presence. This study demonstrates the development of mini Q-bodies using a single-domain heavy chain V-H antibody and different dyes. The results confirm the applicability of this method in detecting proteins.
Article
Engineering, Biomedical
Yi-fan Miao, Qing Ye, Ming-yang Zhang, Lin Gao, Xi-yan Wang, Wen-xin Zhong, Zi-xuan Wang, Zhong-gui He, Chu-tong Tian, Jin Sun
Summary: Due to the serious side effects of intravenous Taxol, the development of an oral chemotherapeutic strategy for paclitaxel (PTX) delivery is highly anticipated. This study explores a series of triglyceride-mimetic prodrugs of PTX with different fatty acid structures to enhance oral antitumor effect and guide the design of similar prodrugs. The results show that the length of fatty acids plays a significant role in in vitro intestinal digestion behavior, lymph transport efficiency, and plasma pharmacokinetics, while the degree of unsaturation has a negligible impact. These findings provide a theoretical basis for the rational design of TG-like PTX prodrugs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuyang Zhao, Ruxue Zhang, Yujie Gao, Yueqing Cheng, Shouzhen Zhao, Mei Li, Haimei Li, Jinhua Dong
Summary: Digoxin is a widely used drug for treating heart diseases. It has a positive effect on heart function but can also be dangerous at low blood concentrations. Therefore, timely detection of blood drug concentration is crucial for controlling drug levels and preventing drug poisoning events.