Article
Chemistry, Medicinal
Gang Li, Jia-Qiang Wu, Xiaojia Cai, Wen Guan, Zhijun Zeng, Yanghui Ou, Xiaoyun Wu, Jiayu Li, Xiangxiang Fang, Jinling Liu, Yali Zhang, Huamin Wang, Canqiang Yin, Hongliang Yao
Summary: A series of diaryl heterocyclic analogues were synthesized as tubulin polymerization inhibitors. Compound 6y exhibited the highest antiproliferative activity against HCT-116 colon cancer cells and effectively inhibited tubulin polymerization in vitro. It also showed high metabolic stability on human liver microsomes and suppressed tumor growth in a HCT-116 mouse colon model without toxicity. These results suggest that 6y represents a new class of tubulin inhibitors worthy of further investigation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Dalal Sulaiman Alshaya, Rana M. O. Tawakul, Islam Zaki, Ali H. Abu Almaaty, Eman Fayad, Yasmin M. Abd El-Aziz
Summary: A new series of acrylic acid and acrylate ester derivatives were synthesized and evaluated for their antiproliferative activity against MCF-7 breast carcinoma cells. Methyl acrylate ester 6e showed the highest cytotoxicity with an IC50 value of 2.57 +/- 0.16 mu M and exhibited inhibition of beta-tubulin polymerization. Compound 6e arrested MCF-7 cells at the G2/M phase and enhanced apoptotic power, while also affecting the gene expression levels of p53, Bax, and Bcl-2.
Article
Chemistry, Medicinal
Chao Tian, Meng Wang, Xueqi Shi, Xuanzhen Chen, Xiaowei Wang, Zhili Zhang, Junyi Liu
Summary: In this study, a series of novel compounds that act as anti-tubulin polymerization and vascular disrupting agents were designed and synthesized. One of the derivatives exhibited strong antiproliferative activities against cancer cells and inhibited tubulin polymerization. It also induced apoptosis through the mitochondrial pathway and suppressed cancer cell migration and vascular network formation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ashish Ranjan Dwivedi, Suraj Singh Rawat, Vijay Kumar, Naveen Kumar, Piyush Anand, Ravi Prakash Yadav, Somesh Baranwal, Amit Prasad, Vinod Kumar
Summary: In this study, 16 novel compounds were synthesized and evaluated for their anticancer activity. It was found that two of the compounds exhibited inhibitory effects on cancer cell proliferation and induced mitochondria-mediated apoptosis. Additionally, one of the compounds showed significant tubulin polymerization inhibition activity. Computational studies revealed that this compound had good binding affinities in the colchicine domain and thermodynamic stability. Therefore, these compounds have the potential to be developed as potent anticancer agents.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Dong Liang, Chen Yu, Zhao Ma, Mingzhao Hu, Jiahui Wang, Xuhui Dong, Lupei Du, Minyong Li
Summary: In this study, the discovery of two series of parbendazole derivatives as tubulin inhibitors for the treatment of head and neck squamous cell carcinoma (HNSCC) was reported. Compound 9q exhibited the best pharmacological activities and pharmacokinetic properties, displaying reasonable inhibition activity on cell proliferation, induction of cell apoptosis, and suppression of cell migration and invasion.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Qidi Huang, Jianai Chen, Xiongchao Shao, Yujie Dong, Weijun Li, Cheng Zhang
Summary: The electrochromic properties of small molecules are greatly improved by optimizing their molecular structures, introducing specific electrochromic units and alkyl chain linkages. The obtained polymer films demonstrate outstanding electrochromic properties with high optical contrast, fast switching time, excellent stability, and high coloration efficiency.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2022)
Review
Medicine, Research & Experimental
Filip Borys, Piotr Tobiasz, Marcin Poterala, Hanna Krawczyk
Summary: This review provides a brief overview of new compounds targeting the dynamic of microtubule-tubulin polymerization/depolymerization. It is divided into three parts focusing on derivatives of stilbene, photoswitchable inhibitors, and macrocyclic compounds as tubulin inhibitors. The authors primarily highlight reports from the past five years and the latest strategies in this field.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Baoxia Liang, Qing Zou, Lintao Yu, Yali Wang, Jun Yan, Baiqi Huang
Summary: Novel indole-containing hybrids derived from Millepachine were synthesized and evaluated for their antitumor activities. Compound 14b showed the most potent cytotoxic activity against human cancer cell lines, being almost 100 times more active than Millepachine. It also demonstrated low cytotoxicity towards normal human cells and equivalent sensitivity towards drug-resistant cells, highlighting its potential for the development of antitumor drugs.
Article
Chemistry, Medicinal
Linyu Yang, Wanhua Zhang, Qiang Qiu, Zhengying Su, Minghai Tang, Peng Bai, Wenting Si, Zejiang Zhu, Yan Liu, Jianhong Yang, Shuang Kuang, Jiang Liu, Wei Yan, Mingsong Shi, Haoyu Ye, Zhuang Yang, Lijuan Chen
Summary: A series of hydroxamic acid-based microtubule destabilizing agents were discovered, among which compound 12b exhibited potential antitumor activity with favorable metabolism stability and high bioavailability. In patient-derived xenograft models, both oral and intravenous administration of 12b showed significant tumor inhibition without obvious toxicity. Overall, compound 12b could serve as a potential MDA for further investigation.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Vajja Krishna Rao, Anvesh Ashtam, Dulal Panda, Sankar K. Guchhait
Summary: This study investigated the discovery of new tubulin polymerization inhibitors using a natural product-inspired strategy and incorporation of an NP-privileged motif. The synthesized compounds showed significant antiproliferative effects in breast cancer cells, and one compound demonstrated potent inhibitory activity on tubulin polymerization and induction of cell death.
Article
Oncology
Clayton J. Bell, Kyle G. Potts, Mary M. Hitt, Desmond Pink, Jack A. Tuszynski, John D. Lewis
Summary: The novel colchicine derivative CR42-24 has shown selective cytotoxicity against various cancer cell lines, with high activity in bladder cancer cell lines. Monotherapy with CR42-24 in an aggressive urothelial carcinoma xenograft model effectively controls large tumors. The combination of CR42-24 with standard chemotherapies gemcitabine and cisplatin demonstrates high synergistic effects, increasing its potential as a novel treatment for urothelial carcinoma.
Article
Chemistry, Medicinal
Lun Tan, Chengyong Wu, Jifa Zhang, Quanwei Yu, Xiye Wang, Lele Zhang, Meiyi Ge, Zhijia Wang, Liang Ouyang, Yuxi Wang
Summary: A series of quinazoline and heterocyclic fused pyrimidine analogues were synthesized based on the X-ray co-crystal structure of lead compound 3a, showing potent antitumor activities. Two analogues, 15 and 27a, exhibited stronger antiproliferative activities than lead compound 3a in MCF-7 cells. Moreover, 15 and 27a showed potent antitumor efficacy and tubulin polymerization inhibition in vitro. The X-ray co-crystal structures of compounds 15, 27a, and 27b in complex with tubulin were resolved, supported by structural optimization and Mulliken charge calculation. This research provides a rational design strategy for colchicine binding site inhibitors (CBSIs) with antiproliferation, antiangiogenesis, and anti-multidrug resistance properties.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qi-Yin Chen, Ranjala Ratnayake, Rafael Hortiguela, Gustavo M. Seabra, Michael D. Cameron, J. Fernando Diaz, Maria Angela Oliva, Hendrik Luesch
Summary: Microtubules are important targets for anticancer drug discovery. Gatorbulin-1 is a new microtubule inhibitor that targets a new site at the tubulin intradimer interface. Through chemical synthesis, simplified gatorbulins were obtained and their structure-activity relationship was investigated. Some specific structural modifications were found to be functionally relevant.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Huajian Zhu, Wenlong Li, Wen Shuai, Yang Liu, Limei Yang, Yuchen Tan, Tiandong Zheng, Hong Yao, Jinyi Xu, Zheying Zhu, Dong-Hua Yang, Zhe-Sheng Chen, Shengtao Xu
Summary: Novel N-benzylbenzamide derivatives 20b and its corresponding disodium phosphate 20b-P show significant anti-cancer activity with excellent safety profile, making them promising anti-tubulin agents for further investigation in cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Domiziana Masci, Michela Puxeddu, Laura Di Magno, Michele D'Ambrosio, Anastasia Parisi, Marianna Nalli, Ruoli Bai, Antonio Coluccia, Pietro Scio, Viviana Orlando, Sara D'Angelo, Stefano Biagioni, Andrea Urbani, Ernest Hamel, Alessio Nocentini, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Cinzia Fionda, Rosa Bordone, Giorgia Della Rocca, Gianluca Canettieri, Claudiu T. Supuran, Romano Silvestri, Giuseppe La Regina
Summary: We synthesized new compounds as inhibitors of human carbonic anhydrase (hCA) with the potential to inhibit the Wnt/beta-catenin signaling pathway. One of the compounds, designated as compound 15, not only showed strong inhibition against hCA XII, but also suppressed the Wnt/beta-catenin signaling pathway and its target genes. It exhibited potent cytotoxicity against cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Neda Fayyazi, Tahereh Mostashari-Rad, Jahan B. Ghasemi, Mehran Mirabzadeh Ardakani, Farzad Kobarfard
Summary: In this study, various computational methods were used to identify potential inhibitors for multiple targets associated with COVID-19, including 3CLpro and RdRp. Through virtual screening and other techniques, several promising compounds were discovered, demonstrating their potential as inhibitors for the two targets. Structure simulations and pharmacophore modeling revealed that specific residues play critical roles in dual activities, showcasing the importance of hydrogen bond features in the binding sites.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Mahdieh Darroudi, Ghodsi Mohammadi Ziarani, Jahan B. Ghasemi, Shahriyar Bahar, Alireza Badiei
Summary: Immobilizing organic ligands containing the imidazole heterocycle on ordered mesoporous silica surface allows for selective removal of precious metal ions from aqueous solution through batch techniques. The adsorption kinetics follow a pseudo-second-order rate equation, confirming a uniform monolayer adsorption process. Langmuir isotherm model analysis shows the adsorption process is a uniform monolayer adsorption, with maximum adsorption capacities for Ag(I), Au(III), and Pd(II) at pH = 4 and 25 degrees C.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2022)
Article
Biochemical Research Methods
Ali Talesh Ramezani, Razieh Rabiei, Alireza Badiei, Ghodsi Mohammadi Ziarani, Jahan B. Ghasemi
Summary: A fluorescence probe based on 8-hydroxyquinoline chitosan silica precursor (HQCS) was designed for the selective detection of Al3+ and Cu2+. The probe exhibited a significant fluorescence signal upon the addition of Al3+ and selective quenching upon the addition of Cu2+. The probe showed a linear range and detection limit suitable for the determination of Cu2+ ions in real samples.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Chemistry, Physical
Reyhaneh Nekooie, Jahan B. B. Ghasemi, Alireza Badiei, Tayebeh Shamspur, Ali Mostafavi, Sahar Moradian
Summary: A g-C3N4/Cu/TiO2 nanocomposite photocatalyst was developed for the degradation of a highly toxic pesticide under visible light irradiation. The incorporation of Cu and TiO2 molecules onto g-C3N4 enhanced absorption in the visible region and improved the separation of photo-excited electron-holes. The nanocomposite showed excellent photocatalytic performance with a 60% degradation rate achieved after 80 minutes of irradiation.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Materials Science, Multidisciplinary
Ghodsi Mohammadi Ziarani, Fatemeh Javadi, Fatemeh Mohajer, Maryam Anafcheh, Alireza Badiei, Jahan B. Ghasemi
Summary: The efficient synthesis of bispyrazole derivatives using Fe3O4@SiO2@Si-Pr-NH-(CH2)2NH2 as a nanomagnetic catalyst under solvent-free conditions was reported. A derivative of bispyrazole was found to act as a Fe3+ ion colorimetric chemosensor, showing a significant color change with high selectivity towards the addition of Fe3+ ion. The study also demonstrated the relationship between the structure of bispyrazoles and the formation of T-shaped conformations.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Mehdi Habibi, Mitra Mousavi, Zahra Shadman, Jahan B. Ghasemi
Summary: In this study, a g-C3N4/MWO4 nanocomposite was prepared and demonstrated to have significant selectivity and sensitivity for H2O2 detection. The excellent electron transfer path and efficient capture of H2O2 are attributed to the synergistic effect between g-C3N4 and CuWO4 in the composite.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ensie Hosseini, Jahan B. Ghasemi, Maryam Shekarchi
Summary: The study developed an analytical method for the simultaneous detection and quantitative determination of three key adulterants in dietary food supplements. The proposed method benefits from optimization and calibration, yielding reliable results.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Automation & Control Systems
Shokoofeh Khani, Fatemeh Mohajer, Ghodsi Mohammadi Ziarani, Alireza Badiei, Jahan B. Ghasemi
Summary: A novel and biocompatible colorimetric method was developed for the detection and speciation of Fe3+ and Fe2+ ions. The method relies on the complex formation of these ions with organic compounds in pomegranate peel extract, and can accurately determine their concentrations in real matrix samples using a multivariate model based on absorption spectra. The detection limits for Fe3+ and Fe2+ were found to be 0.53 and 0.14 μg ml(-1), respectively.
JOURNAL OF CHEMOMETRICS
(2023)
Article
Materials Science, Multidisciplinary
Mitra Mousavi, Sahar Moradian, Pouran Pourhakkak, Gaoke Zhang, Mohammad Mehdi Habibi, Meisam Madadi, Jahan B. Ghasemi
Summary: In this research, novel g-C3N4-nanosheet/ZnMoO4 heterostructures were synthesized, which exhibited significant photocatalytic ability under visible-light irradiation, with 3.77 times and 4.89 times faster Cr(VI) reduction rate compared to g-C3N4-nanosheet and ZnMoO4, respectively, and produced a large amount of ammonium. This improved ability was attributed to increased visible-light absorption and low charge recombination rate.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Faezeh Farzin, Mohammad Kazem Rofouei, Mitra Mousavi, Jahan B. Ghasemi
Summary: This paper reports a green method for hydrogen peroxide production and organic pollutants removal using a two-dimensional nanocomposite. The results show that the prepared binary nanocomposite exhibits a high H2O2 production rate and degradation efficiency, and the Z-scheme-based charge-transfer dynamics effectively improve the photocatalytic performance.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2022)
Article
Chemistry, Physical
Mitra Mousavi, Mohammad Mehdi Habibi, Gaoke Zhang, Pouran Pourhakkak, Sahar B. Moradian, Jahan B. Ghasemi
Summary: In this study, an n-n heterojunction of ZnO/Sb2MoO6 was developed by a facile procedure and its photocatalytic ability for the N-2 fixation process was explored. The physicochemical analyses of ZnO and Sb2MoO6 in the pure samples and the junction material were conducted to understand their structural, chemical, optical, morphological, and textural features. The optimal performance was achieved with ZnO/Sb2MoO6 (20%) nanocomposite, which showed significantly higher ammonium generation compared to pure ZnO and Sb2MoO6. The research provides insights into achieving superior conversion efficiency in N-2 fixation reactions by utilizing the ZnO/Sb2MoO6 heterojunction.
SURFACES AND INTERFACES
(2022)
Article
Engineering, Chemical
Azin Khamesan, Mohammad Mehdi Esfahani, Jahan B. Ghasemi, Faezeh Farzin, Anita Parsaei-Khomami, Mitra Mousavi
Summary: This study explores the constructional modification of Graphitic carbon nitride nanosheet (GCN-ns) with ZnCr layered double hydroxide (ZC-LDH) to enhance its visible light absorption. The incorporation of ZC-LDH onto the surface of GCN-ns improves its photocatalytic abilities, leading to effective degradation of Rhodamine B under UV/vis light irradiation. The self-production of H2O2 on the GCN-ns/ZC-LDH surface accounts for additional hydroxide radical generation, contributing to the improved performance.
ADVANCED POWDER TECHNOLOGY
(2022)
Review
Food Science & Technology
Fatemeh Barzegar, Samaneh Nabizadeh, Marzieh Kamankesh, Jahan B. Ghasemi, Abdorreza Mohammadi
Summary: The increase in chronic diseases worldwide is a cause for concern, largely due to synthetic additives in processed foods. These additives pose health risks and there is a demand for environmentally friendly, natural-based food additives that promote overall health. Nanoemulsion technology can enhance the solubility, stability, and bioavailability of these natural-based additives, making them potential next-generation food additives. This study provides an overview of the production and effects of natural-based food additives using nanotechnology approaches.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mitra Mousavi, Alireza Bonakdar, Anita Parsaei-Khomami, Jahan B. Ghasemi, Pouran Pourhakkak, Mohammad Mehdi Habibi, Mohammad Jafari, Amir H. Jalili, Xuanhua Li
Summary: The design of photocatalysts utilizing sunlight to generate ammonia and remove organic pollutants is important for sustainable chemical industry. A g-C3N4 nanosheet/AgBiS2 nanocomposite with visible-light response was successfully fabricated for the first time. The composite exhibited excellent photocatalytic activity for RhB degradation and N2 fixation, with significant improvements compared to g-C3N4 nanosheet and AgBiS2 alone. The improved activity was attributed to the suitable heterojunction formation, suppressing charge recombination and facilitating transfer.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2023)
Article
Chemistry, Physical
Mozhgan Gholamveysi, Marzieh Ghodrati, Mitra Mousavi, Anita Parsaei-Khomami, Jahan B. Ghasemi, Mohammad Mehdi Habibi, Maryam Shekofteh-Gohari, Parviz Norouzi, Xuanhua Li
Summary: Photoelectrocatalysis is widely used in advanced oxidation processes due to its reduced recombination of charge carriers. This study proposes the formation of a heterojunction between ZnO and MoSe2 to enhance visible light absorption and PEC ability for organic contaminant removal. The as-synthesized nanocomposite was characterized and immobilized onto FTO for electrochemical characterization. The results showed higher PEC activity and recyclability compared to bare ZnO samples, and the operational parameters were investigated to understand their impact on the degradation process.
SURFACES AND INTERFACES
(2023)