Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Review
Chemistry, Multidisciplinary
Dapeng Chen, Qian Xu, Wenjun Wang, Jinjun Shao, Wei Huang, Xiaochen Dong
Summary: Photodynamic therapy (PDT) has great potential for tumor treatment, with type I PDT showing superiority over type II PDT in treating hypoxic tumors. Recent research focuses on developing highly effective type I photosensitizers and addressing key challenges in clinical translations of these photosensitizers.
Article
Biology
Chirine Toufaily, Jerome Fortin, Carlos A. Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C. Hanyaloglu, Terence E. Hebert, Tatiana Fiordelisio, Derek Boerboom, Daniel J. Bernard
Summary: Gonadotropin-releasing hormone (GnRH) controls reproduction by stimulating FSH and LH synthesis via its receptor GnRHR, but the lack of Ctail in mammalian GnRHR may not provide an advantage for LH surge generation. In transgenic mice, addition of Ctail resulted in reduced FSH production and fertility, suggesting a potential role of Ctail in normal reproductive function.
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Article
Immunology
Ai-Mei Chang, Chen-Chih Chen, Ding-Liang Hou, Guan-Ming Ke, Jai-Wei Lee
Summary: The study revealed that GnRH vaccine can reduce hormone concentrations, lead to testicular atrophy and decreased sperm quality, and have an impact on animal mating and reproductive abilities.
Review
Chemistry, Medicinal
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma
Summary: This review discusses the usage, administration, and impact on serum testosterone levels of GnRH receptor agonists and antagonists, focusing on the mechanism of action of the antagonists and their development in clinical studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Tracy A. Burnett, Augusto M. L. Madureira, Janet W. Bauer, Ronaldo L. A. Cerri
Summary: This study found that administration of GnRH at the time of artificial insemination can improve fertility in cows with reduced estrous expression, but increased ovulation rate does not seem to be the direct mechanism behind this relationship.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lisa-Marie Sattler, Hanna A. Schniewind, Waldemar B. Minich, Christoph W. Haudum, Petra Niklowitz, Julia Muenzker, Gabor L. Kovacs, Thomas Reinehr, Barbara Obermayer-Pietsch, Lutz Schomburg
Summary: In European adult control groups and PCOS patients, only a very small fraction have natural GnRH-R-aAb. Our results do not support the hypothesis that GnRH-R is a significant autoantigen in PCOS.
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Agriculture, Dairy & Animal Science
M. H. C. Pereira, B. I. Cappellozza, R. L. A. Cerri, C. P. Sanches Jr, T. G. Guida, L. F. S. P. Barbosa, J. E. P. Santos, J. L. M. Vasconcelos
Summary: This study evaluated the use of a second PGF(2 alpha) treatment in improving pregnancy rates of lactating Holstein cows undergoing timed embryo transfer. The results showed that the use of a second PGF(2 alpha) treatment increased estrus expression and ovulation rates, but did not affect pregnancy rates.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Neurosciences
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo
Summary: The absence of the p140Cap gene in mice leads to abnormalities in fertility, puberty development, and hormone secretion. This may be due to its role in the development of the hypothalamic gonadotropic system and modulation of glutamatergic signaling.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Vitaly Ryu, Anisa Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Kannangara, Liam Cullen, Pokman Chan, TanChun Kuo, Ashley Padilla, Farhath Sultana, Soleil A. Wizman, Natan Kramskiy, Samir Zaidi, Se-Min Kim, Maria New, Clifford J. Rosen, Ki A. Goosens, Tal Frolinger, Vahram Haroutunian, Keqiang Ye, Daria Lizneva, Terry F. Davies, Tony Yuen, Mone Zaidi
Summary: There is increasing evidence that anterior pituitary hormones have multiple functions in regulating somatic tissues and brain receptors. A comprehensive neuroanatomical atlas on the expression of TSHR, LHCGR, and FSHR has been created using single-transcript detection technology. This atlas provides a vital resource for studying the impact of glycoprotein hormone receptors on somatic function and may uncover new pathways for human disease.
Review
Cell Biology
Fabrizio Fontana, Patrizia Limonta
Summary: Understanding the molecular mechanisms of prostate cancer progression to the castration-resistant stage is crucial for improving therapeutic options. The activation of the androgen/androgen receptor axis and the GnRH/GnRH-R axis in CRPC cells play significant roles in antitumor activity, suggesting potential therapeutic implications.
Article
Andrology
Hiroshi Sasaki, Kenta Miki, Kojiro Tashiro, Keiichiro Mori, Fumihiko Urabe, Wataru Fukuokaya, Takahiro Kimura, Shun Sato, Hiroyuki Takahashi, Manabu Aoki, Shin Egawa
Summary: The recovery patterns of hormonal profiles after short-term (12 weeks) neoadjuvant ADT differ between GnRH antagonists and GnRH agonists. The choice between these drugs matters and may have a clinical impact depending on the primary objective of ADT.
Article
Geriatrics & Gerontology
Dorota Walkiewicz, Zofia Wicik, Monika Puzianowska-Kuznicka
Summary: The study identified pathways associated with age-related changes in human B lymphocytes, including the gonadotropin-releasing hormone receptor (GnRHR) pathway, which is involved in both aging and lymphocyte activation. Inhibition of the GnRHR pathway reduced cell proliferation, increased apoptosis, and led to decreased immunoglobulin G synthesis in B lymphocytes, with a more pronounced effect in centenarian cells compared to young cells.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Materials Science, Multidisciplinary
Zhuo Li, Shan Lu, Xingjun Li, Zhuo Chen, Xueyuan Chen
Summary: The growing crisis of antibiotic resistance is driving the need for advanced and sustainable antibacterial strategies. Lanthanide-doped upconversion nanoparticles (UCNPs) with unique photophysical properties have been innovatively explored for bacterial detection and therapy, showing promise in addressing challenges in the post-antibiotic era. This review highlights the interface engineering for bacteria-targeted UCNP nanoplatforms, discusses the principles and advantages of various upconversion detection strategies, and summarizes the latest progress in UCNP-based antibacterial applications, particularly in deep-tissue infection imaging and therapy. Concerns and future efforts for practical applications are also addressed in this review.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Physics, Applied
Junyi Wang, Youlin Wang, Xiaohang Chen, Jincan Chen, Shanhe Su
Summary: In this study, a model of a thermophotovoltaic device that combines a near-field thermal emitter and a hot-carrier solar cell is established. The study introduces the concept of fluctuating electromagnetic near-field theory for radiative thermal transport and Landauer's formula for carrier extraction. The expressions for efficiency and power output are derived, and the impact of voltage and extraction energy of energy selective contacts on the device performance is revealed. The results demonstrate that exploiting radiation between the emitter and the cell and extracting carriers through electron tunneling effects can significantly enhance the efficiency of the proposed device.
APPLIED PHYSICS LETTERS
(2023)
Article
Engineering, Chemical
Tianyu Gao, Depeng Wang, Lichao Xia, Shanshan Zhao, Ronghua Xu, Hanmin Zhang, Fangang Meng, Zanmin Zhou, Jincan Chen, Wanli Liu
Summary: Membrane fouling is a major issue in membrane bioreactors (MBRs) that limits their stable operation. The nature of residual foulants after chemical cleaning is not well understood. In this study, fouled membranes from a large-scale MBR were analyzed to identify the key components resistant to chemical cleaning. The results showed that certain foulants, such as uronic acids, are responsible for irreversible fouling. The interaction between bio-cakes also plays a significant role in membrane fouling. Keystone taxa, such as c_WS6 and c_Deltaproteobacteria, were found to contribute to the accumulation of organic foulants. These findings provide insights for fouling control in MBRs.
Article
Pharmacology & Pharmacy
Hanlin Li, Zhiyou Wang, Shujuan Yu, Shanli Chen, Yang Zhou, Yuhan Qu, Peng Xu, Longguang Jiang, Cai Yuan, Mingdong Huang
Summary: In this study, a targeting drug carrier called uPAR targeting carrier (uPARTC) was developed, which can bind to both murine and human uPAR proteins. The carrier, genetically fused to human serum albumin, effectively inhibited proliferation of murine and human uPAR-overexpressing cells and exhibited potent antitumor efficacy in mice with hepatoma. This work provides a promising tumor targeting drug carrier that overcomes the species-specificity challenge of uPAR targeting agents and can be used to deliver other cytotoxic compounds.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Physics, Applied
Shanhe Su, Zhiyuan Lin, Jincan Chen
Summary: A quantum engine powered by quantum measurement is introduced, enabling the conversion of heat into work without the need for compression and expansion of the resonance frequency within a finite-time unitary transformation. The study derives the work output, quantum heat, and efficiency, emphasizing the significance of thermal divergence in open quantum systems. The optimization of the measurement basis to enhance performance is achieved by linking thermal divergence to nonequilibrium free energy and entropy. The spin-engine architecture presents a comprehensive platform for future investigations into harnessing work from quantum measurements.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Medicinal
Yang Zhou, Meiru Song, Daoqing Xie, Shufeng Yan, Song Xie, Meiqin Cai, Hanlin Li, Le Shang, Longguang Jiang, Cai Yuan, Mingdong Huang, Jinyu Li, Peng Xu
Summary: This study discovered the potential antitumor and antimetastatic effects of diltiazem and glibenclamide, commonly used hypotensive and antidiabetic drugs, on the urokinase receptor (uPAR). The study provides potent uPAR inhibitors and demonstrates the off-label antitumor and antimetastatic uses of diltiazem and glibenclamide.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Fisheries
Jun Bo, Ronghui Zheng, Yulu Jiang, Jincan Chen, Chao Fang, Christyn Bailey, Yusheng Zhang, Jae-Seong Lee, Helmut Segner
Summary: Global warming and changes in environmental conditions may impact the health of marine species. This study examined the liver transcriptome and proteome of the hybrid grouper to understand the physiological pathways affected by climate change-related stressors. The results revealed time-dependent and stressor-specific responses, with elevated temperature having a dominant effect.
Article
Chemistry, Physical
Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen, Peng Xu
Summary: This study reports a serum-stable supramolecular drug delivery system, consisting of peptide-photosensitizer conjugates, that can effectively encapsulate and control release multiple chemotherapeutics in tumor tissues. The system enhances the anti-tumor effects of the chemotherapeutics and reduces adverse effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Environmental
Yuhan Mai, Zhiyou Wang, Yang Zhou, Guodong Wang, Jingyi Chen, Yuxin Lin, Panpan Ji, Wei Zhang, Qian Jing, Liyun Chen, Zheng Chen, Haili Lin, Longguang Jiang, Cai Yuan, Peng Xu, Mingdong Huang
Summary: This study presents a new series of QACs, PACs, which enhance the biosafety and antimicrobial efficacy of QACs by substituting the alkyl chain with a phthalocyanine moiety. PACs demonstrate superior selectivity and antibacterial activity, and show promising therapeutic effects in a mouse model. This study provides a new strategy to improve the application range of QACs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Jincan Chen, Xinhua Guo, Dunhui Li, Hong Tang, Jie Gao, Wenzhu Yu, Xufeng Zhu, Zirong Sun, Zunnan Huang, Lanmei Chen
Summary: We designed and synthesized three new carboline-based cyclometalated iridium complexes, which exhibited high potential antitumor effects and induced cell death through mitochondrial events and activation of the caspase pathway. These novel iridium complexes also demonstrated a prominent inhibitory effect on tumor growth.
Article
Medicine, Research & Experimental
Lin Yang, Qiuling Zhao, Wenbin Liu, Ting Chen, Xiuliang Qiu, Jincan Chen, Shengqiang Huang, Ruyi Huang, Liangliang Dong
Summary: Inhibition of HPK1 enhances the efficacy of anti-PD-1 immunotherapy in non-Hodgkin's lymphoma, suggesting that HPK1 inhibitors are promising drug targets for cancer immunotherapy.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Physics, Fluids & Plasmas
Jingyi Chen, Youlin Wang, Jincan Chen, Shanhe Su
Summary: The Drazin inverse of the Liouvillian superoperator is used to determine the dynamics of a time-dependent system governed by the Markovian master equation. Under the condition of slow driving, the perturbation expansion of the density operator of the system in powers of time can be derived. A finite-time cycle model of the quantum refrigerator driven by a time-dependent external field is established, and the Lagrange multiplier method is adopted to find the optimal cooling performance. The effects of the frequency exponent determining dissipation characteristics on the optimal performance of the refrigerator are discussed systematically.
Article
Chemistry, Multidisciplinary
Xinyuan Liao, Panpan Ji, Kunxiang Chi, Xueying Chen, Yang Zhou, Shanli Chen, Yuan Cheng, Robert Flaumenhaft, Cai Yuan, Mingdong Huang
Summary: Rutin, a flavonoid, has demonstrated anti-thrombotic efficacy through inhibition of protein disulfide isomerase. However, its low aqueous solubility and high dose limit therapeutic use. Chelation of zinc ions significantly increases rutin solubility and enhances its inhibition of PDI. This study provides a strategy to enhance flavonoids' anti-thrombotic properties by zinc chelation.
Article
Astronomy & Astrophysics
Shanhe Su, Jincan Chen
Summary: It is demonstrated that the equivalence between the Nernst theorem and the heat capacity statement of the third law of thermodynamics can be mathematically proven through a simple method.
MODERN PHYSICS LETTERS A
(2023)
Article
Materials Science, Biomaterials
Yuhui Zhang, Xiaohong Pan, Haixing Shi, Yaqi Wang, Wenzhen Liu, Liangzhi Cai, Le Wang, Huanhuan Wang, Zhuo Chen
Summary: In this study, four novel AIE-PSs were developed with enhanced fluorescence and ROS generation abilities. Through appropriate molecular engineering, their absorption and emission peaks were shifted to longer wavelengths, and their singlet oxygen quantum yields were successfully increased. The success of this molecular engineering indicates a new strategy for the design of advanced AIE-PSs for deep-tissue PDT.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
