Article
Acoustics
W. J. Hogan, A. J. Moon-Grady, Y. Zhao, N. M. Cresalia, H. Nawaytou, E. Quezada, M. Brook, P. McQuillen, S. Peyvandi
Summary: This study used maternal hyperoxygenation (MH) to evaluate cerebrovascular reactivity in fetuses with specific congenital heart disease (CHD), finding that fetal response to high oxygen varied depending on the underlying CHD diagnosis, suggesting that cardiovascular physiology may influence the autoregulatory capacity of the fetal brain.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia L. Starodubtseva, Alisa O. Tokareva, Maria V. Volochaeva, Alexey S. Kononikhin, Alexander G. Brzhozovskiy, Anna E. Bugrova, Angelika V. Timofeeva, Evgenii N. Kukaev, Victor L. Tyutyunnik, Natalia E. Kan, Vladimir E. Frankevich, Evgeny N. Nikolaev, Gennady T. Sukhikh
Summary: Intrauterine growth restriction (IUGR) causes disturbances in maternal plasma proteomics, involving plasma lipoprotein assembly, remodeling, and clearance; lipid metabolism; hemostasis; and immune system regulation. Different patterns were observed between early- and late-onset IUGR in terms of coagulation and fibrinolysis systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Minh Son Pham, Dinh Vinh Tran, Chi Kong Pham, Thi Linh Giang Truong, Vu Quoc Huy Nguyen
Summary: This study found that there was a significant difference in PVPI values in FGR cases compared to the normal growth group. There was a positive correlation between PVPI and UAPI, and a negative correlation between PVPI and UA pH. PVPI might have a prognostic meaning in predicting UA pH at birth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Multidisciplinary Sciences
Georgios Moros, Theodora Boutsikou, Charalambos Fotakis, Zoe Iliodromiti, Rozeta Sokou, Theodora Katsila, Theodoros Xanthos, Nicoletta Iacovidou, Panagiotis Zoumpoulakis
Summary: The study found a clear association between altered metabolomic profiles in maternal and cord blood in IUGR pregnancies. Elevated levels of amino acids alanine, leucine, valine, isoleucine, and phenylalanine in IUGR pregnancies suggest a connection with impaired amino acid metabolism and transplacental flux. The increased levels of branched chain amino acids in intrauterine growth restricted pregnancies were linked with increased insulin resistance. Lower glycerol levels were attributed to imbalance between gluconeogenesis and glycolysis pathways, indicating poor glycolysis.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Beth L. Pineles, Hector Mendez-Figueroa, Suneet P. Chauhan
Summary: This study aimed to compare the adverse outcomes of neonates and mothers with detected and undetected small for gestational age. The results showed that although undetected small for gestational age had some complications, antenatal detection of small for gestational age was not associated with improved neonatal adverse outcomes.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Emmanuel Attali, Yariv Yogev
Summary: Advanced maternal age is an increasingly relevant issue in high-income developed countries due to lower fertility rates, increased need for assisted reproductive therapy, and rising comorbidities such as hypertension and diabetes. Recent publications reviewed and summarized the impact of advanced maternal age on pregnancy outcomes.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Multidisciplinary Sciences
Lina Youssef, Jezid Miranda, Miquel Blasco, Cristina Paules, Francesca Crovetto, Marta Palomo, Sergi Torramade-Moix, Hector Garcia-Caldero, Olga Tura-Ceide, Ana Paula Dantas, Virginia Hernandez-Gea, Pol Herrero, Nuria Canela, Josep Maria Campistol, Joan Carles Garcia-Pagan, Maribel Diaz-Ricart, Eduard Gratacos, Fatima Crispi
Summary: Proteomics analysis revealed significant differences at the protein level between early-onset severe preeclampsia and uncomplicated pregnancies, with activation of complement and coagulation cascades identified as important pathways. The study suggests potential therapeutic targets within the complement and coagulation pathway for early-onset severe preeclampsia.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Meagan A. Barry, Susannah Colt, Zorimel Vargas, Christopher Barry, Veronica Tallo, Marianne J. Sagliba, Amabelle J. Amoylen, Jennifer F. Friedman, Emily A. McDonald
Summary: The study found that maternal hookworm infection is associated with poor nutritional outcomes, anemia, and impaired cognitive performance. In a cohort of women in Leyte, Philippines, it was observed that maternal hookworm infection is associated with poor intrauterine growth characteristics only among male offspring, with lower birth weight, head circumference, and placental surface area. Male neonates also had higher insulin-like growth factor 2 (IGF-2) and lower adiponectin in cord blood.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Lianbin Xu, Jia Zeng, Huanan Wang, Hongyun Liu
Summary: Abnormal arginine metabolism is closely related to the development of pregnancy complications such as IUGR, PE, and GDM. Increased maternal arginine concentration is associated with IUGR and GDM cases, but not with PE cases. Subgroup analysis suggests that non-fasting arginine concentration significantly increases in GDM and severe IUGR pregnancies, but the change pattern varies depending on ethnicity. Only severe PE patients have higher plasma arginine concentrations.
Article
Hematology
Evangelia Vlachodimitropoulou, Maciej Garbowski, Shelley Anne Solomon, Nimrah Abbasi, Gareth Seaward, Rory Windrim, Johannes Keunen, Edmond Kelly, Tim Van Mieghem, Nadine Shehata, Greg Ryan
Summary: Red blood cell alloimmunisation with anti-D and anti-K are the main causes of fetal hemolytic disease requiring intrauterine red cell transfusion. Studies have shown that certain hematological parameters can predict adverse fetal or neonatal outcomes, including preterm birth, intrauterine fetal demise, neonatal death, and need for neonatal transfusion. Identifying these predictors can help guide pregnancy management and improve outcomes for these pregnancies.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chelsie B. Steinhauser, Colleen A. Lambo, Katharine Askelson, Gregory W. Burns, Susanta K. Behura, Thomas E. Spencer, Fuller W. Bazer, Michael Carey Satterfield
Summary: Placental development is modified in response to maternal nutrient restriction, leading to different fetal growth rates. Differences in gene expression and function were found between SGA and NR NonSGA placentomes, with overrepresentation of genes related to natural-killer-cell-mediated cytotoxicity in SGA placentomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Shani S. Swissa, Joel Baron, Dan Tirosh, Shimrit Yaniv-Salem, Ilan Shelef, Reli Hershkovitz, Ofer Beharier
Summary: The study found that maternal serum S100B concentration significantly increased in FGR fetuses with brain sparing, indicating potential intrauterine cerebral injury. Following the occurrence of IVH, maternal serum S100B concentration surged.
PRENATAL DIAGNOSIS
(2022)
Article
Obstetrics & Gynecology
Yan Jiao, Yan Liu, Hongyuan Li, Zimeng Song, Shiliang Wang, Jiao Zhang, Jian Li, Jia Liu, Peng Wang, Yanhong Chen
Summary: HELLP syndrome is a severe complication of pregnancy involving multiple systems of the whole body. There is limited evidence on the association between proteinuria and the severity of HELLP and its maternal and neonatal outcomes. A study on 106 pregnant women showed that increased proteinuria was related to the severity of HELLP and its adverse outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Biochemistry & Molecular Biology
Victor H. Parraguez, Francisco Sales, Oscar A. Peralta, Monica De los Reyes, Alfonso Campos, Javier Gonzalez, Wolfgang Peralta, Camila Cabezon, Antonio Gonzalez-Bulnes
Summary: The study found that supplementation with herbal antioxidants during pregnancy significantly improved reproductive efficiency, litter traits, and piglet performance. This included increased number of live-born piglets and total litter weight, while reducing the incidence of low-weight piglets. However, the supplementation did not affect the number of stillbirths and mummified newborns.
Article
Obstetrics & Gynecology
Sonali S. Dash, Pramila Jena, Swetaparna Khuntia, Mona Pathak, Sudhanshu K. Rath
Summary: Combining UAPI values from the first and second trimesters improves the predictive diagnosis of pregnancy-induced hypertension (PIH), with no extra cost to the patient.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)