Article
Polymer Science
Yanping Zuo, Qiwen Li, Qiuchan Xiong, Jing Li, Chengfang Tang, Yaochao Zhang, Danyang Wang
Summary: Bone tissue engineering has been successful in repairing bone defects, but current materials have limitations. Biologic scaffolds made from nano-hydroxyapatite and collagen can overcome these limitations and promote tissue reconstruction. Introducing naringin, a natural flavonoid, into the scaffold enhances bone tissue regeneration potential.
Article
Chemistry, Applied
Sihan Zhang, Guanglei Zhao, Wei Ma, Yanghui Song, Cheng Huang, Chong Xie, Kebing Chen, Xiaofeng Li
Summary: A porous chitosan nanofiber scaffold (CSNFS) with an extracellular matrix-like structure was prepared through a cross-linking reaction, showing high porosity and adequate micro-scale pores. CSNFS has good mechanical strength and biocompatibility, and can be used as a repair material for bone tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Chunyang Ma, Hetong Wang, Yongjie Chi, Yanling Wang, Le Jiang, Nan Xu, Qiong Wu, Qingling Feng, Xiaodan Sun
Summary: Collagen fibers in the body have a complex arrangement, which plays an important role in cell adhesion, migration, proliferation, and secretion. Oriented collagen fiber scaffolds have shown exciting results in tissue repair. Bone is crucial for bearing loads in the human body, and the arrangement of collagen fibers in bone significantly affects its mechanical properties and physiological functions. Oriented collagen fiber scaffolds can promote new bone growth and induce cells to secrete oriented extracellular matrix. However, the complex arrangement of collagen fibers in bone poses challenges for bone tissue repair and bionics.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Chemical
Itay Zusmanovitch, Thabet Asbi, Oshrat Regev, Hadar Zigdon Giladi, Havazelet Bianco-Peled
Summary: The study aimed to create an improved scaffold for bone tissue engineering that meets the requirements of cells, cytokines, and mechanical demands. By using an integrative approach and considering crucial design criteria, such as high porosity, a wide range of pore sizes, a hydrophilic and rough surface, and biofunctionalization, polycaprolactone (PCL) was chosen as the scaffold material and its bioactivity was improved using various methods. The thoroughly characterized scaffolds demonstrated enhanced cell adhesion and proliferation, as well as high hydrophilicity, high porosity with interconnected pores, stiffness, and improved bioactivity compared to other studied scaffolds, making them a promising platform for bone engineering.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Ashwathi Vijayalekha, Suresh Kumar Anandasadagopan, Ashok Kumar Pandurangan
Summary: Bone regeneration is a complex physiological process that occurs throughout a person's life. Current bone repair methods have limitations, while tissue engineering offers potential for repairing damaged tissue. Collagen-based biomaterials, particularly collagen type I, play a crucial role in bone tissue engineering.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Hakimi, Hamed Jafari, Samaneh Hashemikia, Siamak Shabani, Ali Ramazani
Summary: This study aimed to prepare a novel organic-mineral nanofiber/hydrogel of chitosan-polyethylene oxide (CS-PEO)/nanoclay-alginate (NC-ALG) and investigate its effects on mineralization and biocompatibility. The scaffolds composed of CS-PEO and NC-ALG were evaluated for their properties and characteristics. The results showed that the incorporation of NC particles in the scaffold enhanced bone-like apatite formation and demonstrated compatibility and safety for osteoblastic cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Mayumi Kaneko, Keiji Shigeno, Mariko Wakatsuki, Akira Nakada, Yuji Inada, Tatsuo Nakamura
Summary: A study was conducted to investigate the osteoregenerative effect of octacalcium phosphate/weakly denatured collagen scaffold in canine skull defects, compared to weakly denatured collagen scaffold. Results showed that the composite scaffold promoted osteoregeneration better than weakly denatured collagen scaffold, indicating its potential clinical applicability for bone reconstruction in situ.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2021)
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Pietro Cimatti, Isabella Andreoli, Maurizio Busacca, Marco Govoni, Leonardo Vivarelli, Nicolandrea Del Piccolo, Alessandra Maso, Cesare Stagni, Giovanni Pignatti
Summary: This study evaluated the clinical and radiological results of using a biomimetic collagen-hydroxyapatite composite biomaterial in hip revision surgery. The results showed that this material can effectively and safely restore acetabular bone loss, and patients demonstrated significant improvement in functional recovery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Thu-Trang Nguyen, Chih-Chien Hu, Rajalakshmi Sakthivel, Sasza Chyntara Nabilla, Yu-Wen Huang, Jiashing Yu, Nai-Chen Cheng, Yi-Jie Kuo, Ren-Jei Chung
Summary: This study developed a collagen/gamma-polyglutamate acid/hydroxyapatite composite scaffold using 3D printing technology. A collagen/gamma-PGA/hydroxyapatite 2D membrane was also fabricated for comparison. In-vitro and in-vivo experiments showed that the scaffold has good biodegradation and biocompatibility properties, and the collagen-hydroxyapatite scaffold enhances the mechanical properties for osteochondrogenesis.
BIOMATERIALS RESEARCH
(2022)
Review
Polymer Science
Mohammad Javad Javid-Naderi, Javad Behravan, Negar Karimi-Hajishohreh, Shirin Toosi
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Shuqiong Liu, Xiaoyan Wu, Jiapeng Hu, Zhenzeng Wu, Yuying Zheng
Summary: In this study, a series of three-dimensional polylactic acid/hydroxyapatite/graphene oxide drug-loaded biomimetic composite scaffolds with different concentrations of aspirin were successfully prepared, demonstrating good bioactivity and engineering performance.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Hairui Suo, Yu Chen, Jiali Liu, Ling Wang, Mingen Xu
Summary: A novel biphasic scaffold was designed and fabricated using HAp and PCL through a multi-nozzle 3D printing technique, showing mechanical properties between pure HAp and PCL scaffolds. Finite element simulation demonstrated a biomimetic strengthened structure of the biphasic scaffold under compression, suitable for osteochondral tissue engineering applications.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yunqing Yue, Peihu Xu, Zhixin Lei, Kebi Li, Jingyi Xu, Jing Wen, Sining Wang, Wanting Cheng, Sihui Lin, Zhijun Huang, Haixing Xu
Summary: In this study, a bi-layer scaffold was designed and fabricated using drug-dispersed gelatin methacrylate (GELMA) hydrogel and drug-encapsulated coaxial fiber scaffold made from silk fiber (SF) and polylactic acid (PLA). This scaffold showed promising properties for cartilage tissue engineering, including suitable porosity, pore size, mechanical strength, and excellent drug release properties.
Review
Biochemistry & Molecular Biology
Lu Fan, Yanru Ren, Steffen Emmert, Ivica Vuckovic, Sanja Stojanovic, Stevo Najman, Reinhard Schnettler, Mike Barbeck, Katja Schenke-Layland, Xin Xiong
Summary: Synthetic bone substitute materials (BSMs) are replacing autologous grafting for bone tissue engineering (BTE). Collagen type I, a main component of bone matrix, has been crucial in the development of synthetic BSMs. However, collagen-based materials have limitations such as poor mechanical properties and fast degradation, hindering efficient bone replacement and clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Taira Sato, Masanori Kikuchi, Mamoru Aizawa
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2017)
Article
Engineering, Biomedical
Taizo Hiratsuka, Masayoshi Uezono, Kazuo Taakkuda, Masanori Kikuchi, Sho Oshima, Taira Sato, Shoichi Suzuki, Keiji Moriyama
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Materials Science, Ceramics
Chenning Zhang, Tetsuo Uchikoshi, Lihong Liu, Masanori Kikuchi, Izumi Ichinose
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2020)
Article
Biochemistry & Molecular Biology
Sho Oshima, Taira Sato, Michiyo Honda, Yasushi Suetsugu, Kazuhide Ozeki, Masanori Kikuchi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Materials Science, Multidisciplinary
Chenning Zhang, Tetsuo Uchikoshi, Lihong Liu, Masanori Kikuchi, Izumi Ichinose
Article
Engineering, Biomedical
Kaori Iwanami-Kadowaki, Tetsuo Uchikoshi, Masayoshi Uezono, Masanori Kikuchi, Keiji Moriyama
Summary: EPD is a simple, rapid, and inexpensive technique for uniform coatings with controlled thicknesses. The modified EPD technique using Mg2+ ions successfully coated HAp/Col on a Ti substrate with controlled thickness, drastically increasing adhesive strength compared to non-Mg2+ EPD coating. The new coating showed potential for applications in instruments requiring rapid osseointegration at the bone-implant surface.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Materials Science, Multidisciplinary
Chenning Zhang, Tetsuo Uchikoshi, Lihong Liu, Kaori Iwanami-Kadowaki, Masayoshi Uezono, Keiji Moriyama, Masanori Kikuchi
Summary: Antibacterial-functionalized Ag-loaded hydroxyapatite coatings were successfully fabricated by the EPD process, showing potential application in implant surgery for preventing bacterial infection. The coatings have strong adhesion due to the use of Mg2+ as an inorganic binder. This surface antibacterial function improves surgical success.
Article
Materials Science, Ceramics
Masanori Kikuchi
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2020)
Article
Electrochemistry
Chenning Zhang, Tetsuo Uchikoshi, Lihong Liu, Masanori Kikuchi
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2019)
Proceedings Paper
Metallurgy & Metallurgical Engineering
D. M. Zuev, E. S. Klimashina, M. Kikuchi, Sh Oshima, J. Labuta, V. I. Putlyaev, P. V. Evdokimov, Ya Yu Filippov, Tv Safronova
OPEN SCHOOL-CONFERENCE OF NIS COUNTRIES ULTRAFINE GRAINED AND NANOSTRUCTURED MATERIALS
(2018)
Article
Materials Science, Ceramics
Kouichi Yasuda, Toshiyuki Kawano, Masanori Kikuchi, Mamoru Aizawa, Kanji Tsuru, Sadami Tsutsumi
JOURNAL OF ASIAN CERAMIC SOCIETIES
(2018)
Article
Materials Science, Ceramics
Taira Sato, Yuki Shirosaki, Masaki Nagaya, Yoshinori Asano, Kazuaki Nakano, Hiroshi Nagashima, Mamoru Aizawa, Masanori Kikuchi
JOURNAL OF ASIAN CERAMIC SOCIETIES
(2018)
Article
Materials Science, Ceramics
Naga Vijaya Lakshmi Manchinasetty, Taira Sato, Mamoru Aizawa, Sridharan Madanagurusamy, Masanori Kikuchi
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2017)