Article
Chemistry, Multidisciplinary
Dagmara Slota, Karina Pietak, Wioletta Florkiewicz, Josef Jampilek, Agnieszka Tomala, Mateusz M. M. Urbaniak, Agata Tomaszewska, Karolina Rudnicka, Agnieszka Sobczak-Kupiec
Summary: Bioactive calcium phosphate ceramics (CaPs) are important components of bone structure. This study compared different ceramic powders and analyzed their physicochemical properties. The results confirmed the purity of the materials and the validity of the synthesis methods. Additionally, the specific surface area of the ceramics was found to affect drug release efficiency.
Article
Biochemistry & Molecular Biology
Chandan Gupta, Pinky Singh, Shashikant Vaidya, Premlata Ambre, Evans Coutinho
Summary: The major challenges in current cancer chemotherapy, including drug resistance, low efficacy, and non-selectivity, can lead to undesirable side effects. This study presents a solution to these challenges through a dual targeting approach for tumors that overexpress CD44 receptors. A nanoformulation called tHAC-MTX nano assembly, composed of hyaluronic acid (HA) conjugated with methotrexate (MTX) and complexed with a thermoresponsive polymer 6-O-carboxymethylchitosan (6-OCMC) graft poly(N-isopropylacrylamide) [6-OCMC-g-PNIPAAm], was developed. The nano assembly exhibited faster drug release at higher temperatures of tumor tissues and enhanced drug release in the presence of hyaluronidase enzyme. The nanoparticles also showed higher cellular uptake and cytotoxicity in cancer cells that overexpress CD44 receptors, suggesting a receptor binding and cellular uptake mechanism. Such multi-targeting nano-assemblies have the potential to improve the efficacy and reduce the side effects of cancer chemotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Jaroslaw Ciekot, Mateusz Psurski, Katarzyna Jurec, Janusz Boratynski
Summary: The study confirmed the suitability of cellulose as a carrier for methotrexate in cancer therapy, showing potential applications in reducing drug toxicity to normal cells and inhibiting tumor growth. The cellulose-methotrexate conjugate demonstrated lower cytotoxicity and higher inhibition of tumor growth compared to free drug, highlighting new research perspectives in drug delivery systems.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Biotechnology & Applied Microbiology
Yang Liu, Sujeesh Sebastian, Jintian Huang, Tova Corbascio, Jacob Engellau, Lars Lidgren, Magnus Tagil, Deepak Bushan Raina
Summary: This study aimed to investigate the in vivo biodistribution of nHA particles and found that majority of the particles stayed locally at the implantation site after 28 days. The radioactivity observed in the kidney and spleen was minimal, and no pathological changes in vital organs were observed. These findings demonstrate the safety of locally implanted nHA particles for potential use in localized drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Dagmara Slota, Wioletta Florkiewicz, Karina Pietak, Klaudia Pluta, Julia Sadlik, Krzysztof Miernik, Agnieszka Sobczak-Kupiec
Summary: In this study, ceramics-polymer materials based on hydroxyapatite, polyvinylpyrrolidone and betaine were developed as biomaterials. The prepared materials showed strong sorption capacity and bioactivity, with the ability to generate new apatite layers in biological fluid. These findings indicate the potential of the materials as carriers of active substance and in bone tissue regeneration.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
N. Hajiloo, F. Ziaie
Summary: In this experimental work, the EPR signal intensity of hydroxyapatite (HAP) samples was studied from a dosimetric standpoint. HAP samples were prepared in different ways and irradiated with various absorbed doses. The EPR signal intensity of the samples was tested in air at room temperature, showing a linear relationship with dose up to 10 kGy. The findings highlight the importance of fabrication procedure, particle size, carbon impurity, and morphology in determining the EPR signal intensity, with a sample having a grain size of approximately 30 nm and a carbon impurity of 0.47% exhibiting the highest EPR signal intensity with dose.
RESULTS IN PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Islam R. Sayed, Haifa E. Alfassam, Mohamed I. El-Sayed, Ibrahim M. Abd El-Gaied, Ahmed A. Allam, Mostafa R. Abukhadra
Summary: An advanced form of zinc phosphate/hydroxyapatite nanorods with a core-shell structure was hybridized with chitosan to create a safe biocomposite for improved delivery of oxaliplatin during colorectal cancer treatment. The biocomposite displayed higher drug loading capacity, controlled release, and strong cytotoxic effects on cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biotechnology & Applied Microbiology
Muhammad Usman Munir, Sajal Salman, Ibrahim Javed, Syed Nasir Abbas Bukhari, Naveed Ahmad, Naveed Akhter Shad, Farooq Aziz
Summary: Nano-hydroxyapatite is being researched as a crucial component in implants and dental devices due to its non-toxicity and compatibility with dental tissues and bone. It can be used as a bone replacement and drug carrier with high loading potential for pharmaceutical applications.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Samuel Brito Ferreira Santos, Pascally Maria Aparecida Guerra de Araujo, Isabela Alves dos Santos, Ana Cristina Figueiredo de Melo Costa, Alvaro Silva Lima, Libia de Sousa Conrado
Summary: This study proposes a novel approach for the development of magnetic nanoparticles for drug delivery systems, by conducting drug release tests and pharmacokinetic modeling. Results show that the incorporation of hydroxyapatite enhances the drug carrying capacity, as indicated by drug release tests on FeFe2O4 and CoFe2O4 based nanocarriers.
CERAMICS INTERNATIONAL
(2021)
Review
Chemistry, Multidisciplinary
Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias
Summary: Nano-hydroxyapatite (nHA) is effective in promoting bone regeneration as a delivery system, inducing bone regeneration successfully and enhancing osteogenesis when conjugated with other bioactive molecules.
Review
Pharmacology & Pharmacy
Mohd Mughees, Krishna Kumar, Saima Wajid
Summary: Exosomes play a potential role in breast cancer therapy and serve as important drug carriers. In BC cells, exosomes can assist in the efficient targeted delivery of therapeutic substances, including proteins, nucleic acid, and anti-cancer drugs. The properties of exosomes as an efficient delivery system show promise for future exploration and potential use in other forms of cancer as well.
JOURNAL OF DRUG TARGETING
(2021)
Article
Chemistry, Physical
T. S. Anirudhan, R. Suriya, S. N. Anoop
Summary: According to the World Health Organization, the number of cancer deaths in 2018 was 9.6 million, with 1.8 million of those due to colorectal cancer. This article proposes the use of polymeric micelles to deliver two drugs simultaneously and achieve greater efficacy in the treatment of colorectal cancer. In vitro experiments and fluorescence studies support the effectiveness of this method.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Chunxia Gao, Mengmeng Wang, Peizhi Zhu, Caifeng Yan
Summary: The self-assembled hyaluronic add-alendronate-methotrexate nanoparticle showed selective uptake by tumor cells through a dual-tumor-targeted drug loaded system, with low toxicity to normal tissue cells and a proliferation inhibition effect on tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Feng-Huei Lin, Yu-Chen Hsu, Kuo-Chi Chang, Yan-Jye Shyong
Summary: The objective of this study was to develop HAp particles for targeted delivery of honokiol to tumor sites after glioma surgical management. Honokiol is released from the HAp-honokiol particles inside cancer cells through endocytosis and acid lysosomal dissolution. HAp-honokiol treatment showed sustained drug release without compromising drug efficacy, leading to a significant reduction in tumor size in a mouse glioma model. These findings suggest that HAp-honokiol particles have potential as an effective drug delivery system for glioma treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Sebastian S. Arrow, Simone C. Felis, Anna Hillenmayer, Laura D. Strehle, Susanna F. Koenig, Efstathios Vounotrypidis, Armin Wolf, Christian M. Wertheimer
Summary: This study aimed to develop a slow-release, long-term drug carrier composed of polylactide-co-glycolide and methotrexate that can be injected intravitreally. The drug carrier showed inhibitory effects on pathobiological processes in human PVR cells in vitro and maintained stable concentration for 9-11 weeks. It represents a potential therapeutic orphan drug for PVR.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Liwei Feng, Bingdong Li, Yuqi Xiao, Lijuan Li, Yuqian Zhang, Qiannan Zhao, Guifu Zuo, Xianguang Meng, Vellaisamy A. L. Roy
Summary: The modification of Bi2O3 enhances the charge separation of the photocatalyst and improves the activity of Au/TiO2 for H2O2 production. In-situ electron spin resonance studies indicate a single-electron oxygen reduction reaction on the Au/Bi2O3-TiO2 photocatalyst for the production of H2O2. This work highlights the significance of heterojunction structure photocatalyst in enhancing the performance of TiO2 for producing concentrated H2O2.
CATALYSIS COMMUNICATIONS
(2021)
Article
Energy & Fuels
Xianglei Liu, Zekai Mu, Chen Sun, Hang Shi, Xianguang Meng, Ping Li, Yueyue Ling, Bo Cheng, Yimin Xuan, Yulong Ding
Summary: This study demonstrates the potential of achieving efficient solar-driven CO2 reduction based on NiCo-ZIF derived nanostructures at relatively low operating temperature, with high light-to-fuel efficiency and production rates obtained.
Review
Chemistry, Multidisciplinary
Xingyu Yu, Guoping Liu, Tao Wang, Hao Gong, Hongjiao Qu, Xianguang Meng, Jianping He, Jinhua Ye
Summary: The application of solar energy is crucial for addressing the energy crisis and achieving sustainable development. Photo-assisted rechargeable batteries have gained attention due to their ability to directly convert and store solar energy. Among them, photo-assisted lithium-based batteries, with their higher energy density and relatively mature development, have received considerable focus. This Review discusses the design and working mechanism of various photo-assisted lithium-based batteries, as well as the challenges and perspectives for their development.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Haohao Wang, Shouwu Yu, Xianguang Meng, Ziyang Wang, Tian Gao, Shujuan Xiao
Summary: In this experiment, a low-crystalline bimetallic MIL-88A(Co/Fe-2) catalyst was successfully synthesized under mild conditions using fumaric acid as ligand. The catalyst exhibited excellent degradation ability for various dyes, thanks to its changed morphology and coordination structure, which resulted in a narrow band gap and improved photoresponsivity and electron-hole separation efficiency. This research provides a feasible idea for developing efficient photo-Fenton catalysts.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Peirong Liu, Yingrui Xiao, Zhou Yang, Shouwu Yu, Xianguang Meng
Summary: Lead-free double perovskite is a candidate material for green optoelectronic applications due to its low toxicity and human-friendly characteristics. By introducing propylammonium, a larger size 2D double perovskite single crystal (PA)4AgBiBr8 has been grown, which exhibits good X-ray response. The constructed Au/(PA)4AgBiBr8/Au X-ray detector shows high sensitivity.
Article
Chemistry, Multidisciplinary
Hui Song, Hengming Huang, Xianguang Meng, Qi Wang, Huilin Hu, Shengyao Wang, Hongwei Zhang, Wipakorn Jewasuwan, Naoki Fukata, Ningdong Feng, Jinhua Ye
Summary: Direct photocatalytic oxidation of methane to liquid oxygenated products at room temperature is achieved using atomically dispersed nickel anchored on a nitrogen-doped carbon/TiO2 composite (Ni-NC/TiO2) catalyst. The Ni-NC/TiO2 catalyst exhibits high activity and selectivity for the formation of Cl oxygenates, with a yield of 198 umol and a selectivity of 93% in 4 hours. The enhanced performance is attributed to the presence of single-atom Ni-NC sites that facilitate electron transfer and activate O2 to form reactive oxygen species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Spectroscopy
Xieyin Li, Yuqian Zhang, Mian Wei, Manman Wang, Jing Wang, Guifu Zuo
Summary: A rod-like melem with high fluorescence quantum yield was prepared to enhance the chemiluminescence intensity, and a CL sensor based on this system was designed for the detection of reduced glutathione.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Multidisciplinary
Haobing Wen, Sen Huang, Xianguang Meng, Xiaole Xian, Jingjing Zhao, Vellaisamy A. L. Roy
Summary: This article reviews the recent research progress in the design of photocatalytic H2O2 synthesis systems. It discusses strategies to improve the reaction kinetics of H2O2 formation and inhibit H2O2 decomposition through surface functionalization methods. The article emphasizes the design of photocatalysts and the reaction mechanism, and provides an outlook on the possible ways for synthesizing high-concentration H2O2 solution in the future.
FRONTIERS IN CHEMISTRY
(2022)
Review
Crystallography
Xin Zhang, Shouwu Yu, Xianguang Meng, Shujuan Xiao
Summary: Recently, perovskites have emerged as a highly promising semiconductor material for X-ray detection due to their low-temperature fabrication, controllable band gap, and high carrier lifetime. Many researchers have developed green, stable, and efficient lead-free halide chalcogenides in pursuit of stable performance and biological safety. This article provides a brief introduction to the basic principles of X-ray detection, summarizes the outstanding achievements in terms of sensitivity, signal-to-noise ratio, and detection limit, and presents the optoelectronic properties of lead-free halide perovskites and their prospects in X-ray detection.
CRYSTAL RESEARCH AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Shengyao Wang, Bo Jiang, Joel Henzie, Feiyan Xu, Chengyuan Liu, Xianguang Meng, Sirong Zou, Hui Song, Yang Pan, Hexing Li, Jiaguo Yu, Hao Chen, Jinhua Ye
Summary: Tracking the products of CO2 photoreduction is challenging due to low conversion efficiency and carbon contamination. Isotope-tracing experiments are commonly used but often yield false-positive results. Accurate and effective strategies for evaluating CO2 photoreduction products are needed.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Haohao Wang, Shouwu Yu, Tian Gao, Xiaoyao Tan, Xianguang Meng, Shujuan Xiao
Summary: The combination of photocatalysis and Fenton technology using the heterojunction photo-Fenton catalyst MT-2 has shown excellent degradation performance for methylene blue and tetracycline. This study provides an efficient and feasible solution for pollutant treatment, and contributes to the understanding of the synergistic effect between photocatalysis and Fenton catalysis.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Environmental
Teng-Wen Zhao, Han Wu, Yang Jin, Xie-Yin Li, Gui-Fu Zuo, Man-Man Wang
Summary: Sensitive monitoring of environmental contaminants is important, and in this study, a facile hydrothermal method was used to prepare a mesoporous graphitic carbon nitride/cobalt ferrite composite as an adsorbent for bisphenols in water samples. The method showed high adsorption capacity, short extraction time, and good recoveries, making it a promising approach for sensitive and rapid determination of bisphenols in environmental water samples.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Review
Chemistry, Multidisciplinary
Yuxuan Meng, Guoping Liu, Guifu Zuo, Xianguang Meng, Tao Wang, Jinhua Ye
Summary: This article reviews the recent research progress of photocatalytic CO2 reduction systems based on ZnS nanocrystal photocatalysts and focuses on optimizing catalyst design and reaction medium composition to maximize the photoreduction rate of CO2. It provides meaningful insights for developing strategies of universal solar fuel production.
Review
Chemistry, Physical
Yujiao Xia, Yunyun Xu, Xingyu Yu, Kun Chang, Hao Gong, Xiaoli Fan, Xianguang Meng, Xianli Huang, Tao Wang, Jianping He
Summary: The traditional process of synthetic nitrogen-fixing ammonia is energy-consuming and environmentally unfriendly. Therefore, exploring new methods for ammonia synthesis under mild conditions is crucial. Photocatalytic nitrogen fixation utilizes solar energy as an energy source to convert nitrogen to ammonia through photocatalysis at normal temperatures. In recent years, the development of highly efficient photocatalysts has been a hot topic. This study mainly discusses the structure and design of photocatalytic nitrogen-fixing materials, such as introducing vacancies, conducting element doping, and constructing heterojunctions. The study also introduces the oxidation process of N-2 to nitrogen compounds, providing inspiration for the research and development of nitrogen-fixing photocatalysts.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
