Article
Endocrinology & Metabolism
Weiyao Yin, Martina Persson, Sven Sandin
Summary: This study examined the risk of type 1 diabetes mellitus (T1DM) in the offspring of parents with a psychiatric history at the birth of the child. The findings suggested a higher risk of T1DM in children of mothers with psychiatric disorders at delivery, but not in children of fathers with psychiatric disorders or those diagnosed after delivery. The association disappeared after adjusting for T1DM in parents, but remained significant in female offspring. Maternal eating disorder and obsessive-compulsive disorder were independently associated with offspring T1DM.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Khalid Siddiqui, Teena P. George, Salini S. Joy, Assim A. Alfadda
Summary: This study investigates the involvement of risk factors in the severity of CKD among participants with longer duration of diabetes. The results suggest that patients with T2DM and duration of ≥ 15 years, hyperlipidemia, hypertension, and diabetic retinopathy have a higher prevalence of advanced CKD. Additionally, an increased number of risk factors may indicate the severity of CKD in T2D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Randi K. Johnson, Roy Tamura, Nicole Frank, Ulla Uusitalo, Jimin Yang, Sari Niinisto, Carin Andren Aronsson, Anette-G. Ziegler, William Hagopian, Marian Rewers, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris
Summary: The study found that maternal food consumption during late pregnancy was not significantly associated with offspring risk for IA or type 1 diabetes.
Review
Endocrinology & Metabolism
Lowri A. Allen, Peter N. Taylor, Kathleen M. Gillespie, Richard A. Oram, Colin M. Dayan
Summary: This review examines the difference in the transmission rate of type 1 diabetes from affected fathers compared to affected mothers. It explores possible mechanisms for this difference and highlights the importance of understanding it in order to identify individuals at high risk and develop interventions to reduce their risk of disease.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ida H. Thorius, Lise Lotte N. Husemoen, Rikke B. Nordsborg, Amra C. Alibegovic, Mari-Anne Gall, Janne Petersen, Elisabeth R. Mathiesen
Summary: Insulin pump treatment does not reduce the risk of congenital malformations in pregnant women with type 1 diabetes, despite better glycaemic control compared with multiple daily insulin injection. Further studies are needed to explore the efficacy and safety of pump treatment during pregnancy.
Article
Environmental Sciences
Alaa Taha-Khalde, Alon Haim, Isabella Karakis, Sagi Shashar, Ron Biederko, Alexandra Shtein, Eli Hershkovitz, Lena Novack
Summary: The study suggests that exposure to high levels of ozone and solar radiation during gestation may be related to Type 1 diabetes, but more scientific evidence is needed to support this finding.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Public, Environmental & Occupational Health
Lasse Bjerg, Soffia Gudbjornsdottir, Stefan Franzen, Bendix Carstensen, Daniel R. Witte, Marit E. Jorgensen, Ann-Marie Svensson
Summary: This study revealed that the duration of diabetes-related complications is a key factor affecting mortality in individuals with type 1 diabetes, particularly with the highest mortality rate associated with cardiovascular disease in the initial period after diagnosis. After the diagnosis of diabetic kidney disease, the all-cause mortality rate also increases, but stabilizes after a few years.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Endocrinology & Metabolism
Lilah Tsaitlin-Mor, Adva Cahen-Peretz, Yaakov Bentov, Tomer Ben-Shushan, Hagai Levine, Asnat Walfisch
Summary: Early-term delivery poses a modest risk for long-term pediatric type 1 diabetes compared with full-term offspring. Whenever medically possible, elective delivery should be avoided before 39 completed weeks of gestation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Multidisciplinary Sciences
Sangeetha Srinivasan, Sobha Sivaprasad, Ramachandran Rajalakshmi, Ranjit Mohan Anjana, Rayaz A. Malik, Vaitheeswaran Kulothungan, Viswanathan Natarajan, Rajiv Raman, Muna Bhende
Summary: This study examined the retinal structure and function in patients without diabetic retinopathy and found that early retinal functional alterations can be detected in patients with longer diabetes duration, while there were no differences in retinal thickness.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Lue Ping Zhao, George K. Papadopoulos, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Daniel E. Geraghty, Ake Lernmark
Summary: Using deep learning of DQ residue sequences, critical residues and motifs associated with T1D were uncovered on HLA-DQ molecules, including susceptibility and resistance associations. These residues, located on alpha and beta chains, play significant roles in the risk and protection against T1D.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Medha Munshi, Christine Slyne, Atif Adam, Dai'Quann Davis, Amy Michals, Astrid Atakov-Castillo, Katie Weinger, Elena Toschi
Summary: This study investigated the impact of diabetes duration on clinical and functional status in older adults with type 1 diabetes. The results showed that longer duration of diabetes was associated with higher likelihood of depression, hypoglycemia unawareness, lower exercise capacity, lower physical component summary, and greater daily medication use.
Article
Nutrition & Dietetics
Monika Grabia, Renata Markiewicz-Zukowska, Katarzyna Socha, Agnieszka Polkowska, Aneta Zasim, Karolina Boruch, Artur Bossowski
Summary: The occurrence of metabolic syndrome significantly affects the course of diabetes mellitus, leading to deterioration of insulin sensitivity and metabolic control, as well as cardiometabolic complications. This study investigated the relationships between cardiovascular biomarkers, nutritional status, dietary factors, and the occurrence of metabolic syndrome in adolescents with type 1 diabetes and healthy peers from northeast Poland.
Article
Health Care Sciences & Services
Mi-Kyoung Cho, Mi Young Kim
Summary: This study examined factors that contribute to depression among parents of children with type-1 diabetes mellitus (T1DM), a chronic condition that requires constant management. Various complex factors influence parental depression and require further investigation.
Article
Endocrinology & Metabolism
Jamie L. Felton, David Cuthbertson, Megan Warnock, Kuldeep Lohano, Farah Meah, John M. Wentworth, Jay Sosenko, Carmella Evans-Molina
Summary: The study suggests that HOMA2-B may be used as a single-time-point measurement to stratify the risk of developing type 1 diabetes in Aab+ individuals. Lower HOMA2-B values were associated with higher risk and faster progression to type 1 diabetes.
Article
Cardiac & Cardiovascular Systems
Martina Persson, Neda Razaz, Anna-Karin Edstedt Bonamy, Eduardo Villamor, Sven Cnattingius
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Endocrinology & Metabolism
Lue Ping Zhao, George K. Papadopoulos, William W. Kwok, Bryan Xu, Matthew Kong, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding-Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Ake Lernmark
Article
Endocrinology & Metabolism
Ozkan Aydemir, Janelle A. Noble, Jeffrey A. Bailey, Ake Lernmark, Patrick Marsh, Agnes Andersson Svard, Frank Bearoff, Elizabeth P. Blankenhorn, John P. Mordes, Martina Persson, Helena Elding Larsson, Gun Forsander, Sten-Anders Ivarsson, Johnny Ludvigsson, Claude Marcus, Annelie Carlsson
Article
Pediatrics
Josephine Haas, Martina Persson, Eva Hagstrom Toft, Bjorn Rathsman, Anna-Lena Brorsson, Anna Lindholm Olinder
Article
Medicine, General & Internal
Louise Lindberg, Emilia Hagman, Pernilla Danielsson, Claude Marcus, Martina Persson
Article
Medicine, General & Internal
Louise Lindberg, Pernilla Danielsson, Martina Persson, Claude Marcus, Emilia Hagman
Article
Obstetrics & Gynecology
Hanna Amark, Meeli Sirotkina, Magnus Westgren, Nikos Papadogiannakis, Martina Persson
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Medicine, General & Internal
Martina Persson, Signe Opdahl, Kari Risnes, Raz Gross, Eero Kajantie, Abraham Reichenberg, Mika Gissler, Sven Sandin
Article
Multidisciplinary Sciences
Lue Ping Zhao, George K. Papadopoulos, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Daniel E. Geraghty, Ake Lernmark
Summary: Using deep learning of DQ residue sequences, critical residues and motifs associated with T1D were uncovered on HLA-DQ molecules, including susceptibility and resistance associations. These residues, located on alpha and beta chains, play significant roles in the risk and protection against T1D.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Lue Ping Zhao, George K. Papadopoulos, Terry P. Lybrand, Antonis K. Moustakas, George P. Bondinas, Annelie Carlsson, Helena Elding Larsson, Johnny Ludvigsson, Claude Marcus, Martina Persson, Ulf Samuelsson, Ruihan Wang, Chul-Woo Pyo, Wyatt C. Nelson, Daniel E. Geraghty, Stephen S. Rich, Ake Lernmark
Summary: The study identified three amino acid residues of HLA-DRB1 (beta 71, beta 74, beta 86) predictive of T1D risk, with the KAG motif being most strongly associated with increased risk. Other motifs were also found to be linked with T1D risk or protection.
Article
Pediatrics
Emma Hedlund, Johnny Ludvigsson, Helena Elding Larsson, Gun Forsander, Sten Ivarsson, Claude Marcus, Ulf Samuelsson, Martina Persson, Annelie Carlsson
Summary: This study used population-based data in Sweden to investigate the association between month of birth and incidence of type 1 diabetes. The results showed that there was no significant correlation between month of birth and the risk of type 1 diabetes in the entire cohort. However, boys diagnosed before the age of 5 were more likely to be born in May.
Article
Pediatrics
Weiyao Yin, Nora Doring, Monica S. M. Persson, Martina Persson, Kristina Tedroff, Ulrika Aden, Sven Sandin
Summary: The risk of intellectual disability increases weekly as the gestational age moves away from 40 weeks, and this association is consistent across different levels of ID severity.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Medicine, General & Internal
Jenny Bolk, Eleni Simatou, Jonas Soderling, Lisa B. Thorell, Martina Persson, Helene Sundelin
Summary: This study suggests that children with pediatric ischemic stroke have an increased risk of ADHD, especially in those with adverse motor outcomes and/or epilepsy, compared to controls. The risk of ADHD increases after childhood strokes regardless of comorbidities.
Article
Public, Environmental & Occupational Health
Martina Persson, Abraham Reichenberg, Mikael Andersson Franko, Sven Sandin
Summary: This study suggests that maternal type 1 diabetes (T1D) may increase the risk of autism spectrum disorder (ASD) in offspring. It is found that this risk may be mediated by pre-term birth, which affects about one-third of pregnancies with T1D. Additionally, maternal levels of glycated haemoglobin (HbA1c) do not impact the risk of ASD beyond the T1D diagnosis itself.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Weiyao Yin, Jonas F. Ludvigsson, Ulrika Aden, Kari Risnes, Martina Persson, Abraham Reichenberg, Michael E. Silverman, Eero Kajantie, Sven Sandin
Summary: This study investigated the association between psychiatric diagnoses in fathers, mothers, and both parents and gestational age. The results showed that both paternal and maternal psychiatric diagnoses were associated with earlier gestational age, and the risk increased when both parents were diagnosed. The risk also increased when fathers and mothers were diagnosed with different psychiatric disorders. These findings suggest that the presence of psychiatric diagnoses in parents impacts gestational age at birth.
