Article
Chemistry, Multidisciplinary
Evelyn Osehontue Uroro, Richard Bright, Panthihage Ruvini L. Dabare, Debkumar Bera, Jing Yang Quek, Nirmal Goswami, Krasimir Vasilev
Summary: Poly(lactic-co-glycolic) acid (PLGA) was explored as an effective carrier for polycationic silver nanoclusters (pAgNCs), leading to the development of biocompatible pAgNCs@PLGA nanocomposites with potent antimicrobial activity and high biocompatibility, holding promise for their application in medical practice.
Article
Biochemistry & Molecular Biology
Eduardo Lanzagorta Garcia, Marija Mojicevic, Dusan Milivojevic, Ivana Aleksic, Sandra Vojnovic, Milena Stevanovic, James Murray, Olivia Adly Attallah, Declan Devine, Margaret Brennan Fournet
Summary: Curcumin and triangular silver nanoplates (TSNP) incorporated bacterial cellulose (BC) films are highly effective antimicrobial materials with low toxicity. These films inhibit the growth of Escherichia coli and Staphylococcus aureus without causing significant harm to human cells and model organisms. The combination of curcumin and TSNP with BC has great potential for clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Maryam Azizi-Lalabadi, Farhad Garavand, Seid Mahdi Jafari
Summary: Developing novel composite systems using new strategies is a popular area of interest, with a focus on raising awareness of health and safety issues. Utilizing nanoparticles, particularly silver nanoparticles, within composite materials has shown to enhance their physical, mechanical, and antimicrobial characteristics, making them valuable in various applications. Safety precautions and evaluation techniques are crucial aspects in the implementation of nanocomposites containing silver nanoparticles.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Shahia Khattak, Xiao-Tong Qin, Fazli Wahid, Long-Hui Huang, Yan-Yan Xie, Shi-Ru Jia, Cheng Zhong
Summary: Surface oxidation of bacterial cellulose was carried out using the TEMPO-mediated oxidation mechanism, followed by impregnation with silver sulfadiazine to create nanocomposite membranes. Analysis using FTIR and XRD determined the presence of functional groups and crystallinity, while FESEM analysis showed the impregnation of nanoparticles and increased antibacterial activity with higher TOBC and AgSD content. This method retains and enhances the reactivity of BC, making it a promising option for biomedical applications such as wound dressing and tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Juan Zhang, Mengjiao Gao, Wenchao Gao, Peng Yang, Fanhui Meng, Qiang Liu, Honghong Chang
Summary: Drug resistance is a global issue, and it is urgent to develop a new antibacterial agent that can fight drug-resistant bacteria without causing resistance. In this study, indole functionalized silver nanoparticles (Ag NPs) were synthesized to combat drug-resistant bacteria. The modified silver nanoparticles (5NI-Ag NPs and Try-Ag NPs) showed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria. Particularly, Try-Ag NPs exhibited better antibacterial activity against both normal and drug-resistant bacteria, with low minimum inhibitory concentrations. Moreover, resistance generation towards Try-Ag NPs was not easily observed.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Gabriela Ribeiro dos Santos, Victoria Soares Soeiro, Carolina Fernanda Talarico, Janaina Artem Ataide, Andre Moreni Lopes, Priscila Gava Mazzola, Thais Jardim Oliveira, Jose Martins Oliveira Junior, Denise Grotto, Angela F. Jozala
Summary: This study investigates the loading of nisin into bacterial cellulose (N-BC) and evaluates its morphological characteristics, cytotoxicity, antimicrobial activity, and stability. The results show that bacterial cellulose enhances the antimicrobial activity of nisin and acts as a barrier for other compounds, protecting the stability of nisin. Therefore, the N-BC system could be useful for pharmaceutical and food applications.
Article
Food Science & Technology
Hongyan Yang, Lan Wang, Fei Pan, Libo Yuan, Heng Du, Pei Zhang, Kui Lu
Summary: In this study, a self-assembling lipopeptide C12-CL5 was developed by modifying the structure of the antimicrobial peptide CL5. The C12-CL5 showed potent activity against both Gram-negative and Gram-positive bacteria, with good thermal stability, excellent salt tolerance, and strong and rapid killing kinetics. The study also revealed the antimicrobial mechanism of C12-CL5, providing insights and basis for the development of potent and broad-spectrum antimicrobial peptides in the food industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adewale O. Fadaka, Samantha Meyer, Omnia Ahmed, Greta Geerts, Madimabe A. Madiehe, Mervin Meyer, Nicole R. S. Sibuyi
Summary: This study investigated the antimicrobial and cytotoxicity effects of silver nanoparticles (AgNPs) synthesized using different reducing agents. The results showed that AgNPs synthesized using gum arabic had higher bactericidal activity and non-selective cytotoxicity towards normal and cancer cells. AgNPs synthesized using other reducing agents had insignificant antimicrobial activity and cytotoxicity at certain concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Sasiporn Audtarat, Piyorot Hongsachart, Thananchai Dasri, Sirinart Chio-Srichan, Siriwat Soontaranon, Wullapa Wongsinlatam, Supachai Sompech
Summary: A nanocomposite material of silver nanoparticles deposited on nanofibrillated bacterial cellulose (BC-AgNPs) was fabricated for antimicrobial applications and fully characterized using various techniques. The results show that the BC-AgNPs composite has good antimicrobial activity against Escherichia coli but less against Staphylococcus aureus.
Article
Materials Science, Multidisciplinary
Wittaya Homwan, Konkanok Chaisen, Sasiporn Audtarat, Wittaya Suwonnachot, Thananchai Dasri
Summary: Composite nanomaterials based on silver nanoparticles (AgNPs) were developed to synergistically act with bacterial cellulose (BC) and showed promising antimicrobial activity. The impregnation of AgNPs into the porous BC network was confirmed by field emission scanning electron microscopy (FESEM), and the composite formulation was verified by x-ray diffraction (XRD) analysis. Bactericidal tests demonstrated a significant reduction in the growth of common pathogens when exposed to BC@AgNPs nanocomposites, indicating their potential as antibacterial materials for various medical and environmental applications.
MATERIALS RESEARCH EXPRESS
(2023)
Article
Biochemistry & Molecular Biology
Pasakorn Jutakridsada, Totsaporn Suwannaruang, Pornnapa Kasemsiri, Natthida Weerapreeyakul, Jesper T. N. Knijnenburg, Somnuk Theerakulpisut, Khanita Kamwilaisak, Prinya Chindaprasirt
Summary: AgNPs/Ag-cCNC were prepared from Eucalyptus pulp using a three-step process. The Ag-cCNC exhibited slow and controllable release of Ag+ ions and showed potential anticancer activity in MCF-7 cells. The samples also demonstrated shear thinning properties, making them suitable for drug delivery by injection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Jie Cheng, Wenlong Tu, Edison Huixiang Ang, Marliyana Aizudin, Fu Yang, Xinwei Zhou, Dawei Yu, Fanghua Li, Zengjing Guo, Yiyan Song
Summary: In this study, an excellent Ag-AlNiO nanocomposite antimicrobial material was reported by Nidoping AlOOH triggering better implanting of Ag nanospecies. The nanoflower-like configuration of the Ni-doping AlOOH favors the formation of refined active silver nanospecies. Ag-AlNiO shows good biocompatibility and broad-spectrum antimicrobial properties against various gram-negative bacteria, gram positive bacteria, and fungi. Compared to Ag-AlO, Ag-AlNiO has a prolonged inhibitory effect on microbial growth.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biochemistry & Molecular Biology
Alexander Vasil'kov, Ivan Butenko, Alexander Naumkin, Anastasiia Voronova, Alexandre Golub, Mikhail Buzin, Eleonora Shtykova, Vladimir Volkov, Vera Sadykova
Summary: Researchers have developed new Ag-containing nanocomposites by modifying bacterial cellulose (BC) with Ag nanoparticles. The BC was obtained in the form of films and spherical beads, and the Ag nanoparticles were synthesized using metal-vapor synthesis (MVS). Characterization of the materials showed that the BC-based nanocomposites exhibited antimicrobial activity and had potential medical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Youwen Zhang, Limin Dong, Lang Sun, Xinxin Hu, Xiukun Wang, Tongying Nie, Xue Li, Penghe Wang, Pengbo Pang, Jing Pang, Xi Lu, Kaihu Yao, Xuefu You
Summary: Antivirulence strategy is being developed as a nontraditional therapy to counter microbial resistance. However, current antivirulence agents are limited in their antibacterial spectrum. In this study, a novel compound called ML364 was found to inhibit the production of specific substances in Pseudomonas aeruginosa and Staphylococcus aureus. Further investigation showed that ML364 may interfere with the autoinducer-2 (AI-2) quorum sensing system, resulting in broad-spectrum antivirulence effects against multiple pathogens.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
David Panacek, Lucie Hochvaldova, Aristides Bakandritsos, Tomas Malina, Michal Langer, Jan Belza, Jana Martincova, Renata Vecerova, Petr Lazar, Katerina Polakova, Jan Kolarik, Lucie Valkova, Milan Kolar, Michal Otyepka, Ales Panacek, Radek Zboril
Summary: The study reveals that GCN/Ag can kill silver-nanoparticle-resistant bacteria at lower concentrations and with potent antibacterial activity. The strong dative bonds between cyanographene and silver result in minimal silver ion leaching and high cytocompatibility. Molecular dynamics simulations suggest strong interaction of GCN/Ag with bacterial membrane, independent of silver nanoparticles or ions release.
Article
Chemistry, Physical
Mani Pujitha Illa, Anil D. Pathak, Chandra S. Sharma, Mudrika Khandelwal
ACS APPLIED ENERGY MATERIALS
(2020)
Article
Chemistry, Applied
Shivakalyani Adepu, Mudrika Khandelwal
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Shivakalyani Adepu, Hongrong Luo, Seeram Ramakrishna
Summary: Drug-eluting stents are widely used to prevent neointimal hyperplasia, and new coatings using herbal anti-proliferative agents and heparin-tagged polymers offer non-thrombogenic properties, sustained drug release, and complete degradation within 14 weeks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Materials Science, Multidisciplinary
Urbashi Mahanta, Mudrika Khandelwal, Atul Suresh Deshpande
Summary: The rapid spread of microorganisms can lead to serious consequences, and the development of antimicrobial surfaces is essential to prevent epidemics. Understanding the interaction between microorganisms and surfaces is crucial, and physical and chemical modifications can be used to inhibit microbial attachment and growth. The review focuses on different approaches to create antimicrobial surfaces, classifying them into patterned surfaces, functionalized surfaces, superwettable surfaces, and smart surfaces.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Mani Pujitha Illa, Chandra S. Sharma, Mudrika Khandelwal
Summary: Adding an iron catalyst to modify the fermentation media used for bacterial cellulose production enhances the performance of carbon nanofibers, showing potential for better application in lithium-ion batteries.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Materials Science, Paper & Wood
Peddapapannagari Kalyani, Mudrika Khandelwal
Summary: In situ modification of bacterial cellulose (BC) by adding agar and chitosan to the culture media leads to structural and morphological tuning, affecting water absorption/retention and rheological behavior. Agar-modified BC shows reduced pore volume and denser network with lower water absorption, while Chitosan-BC exhibits lower pore volume and reduced swellability with lower water retention. The viscoelastic deformation mechanism and water absorption behavior are discussed with respect to pore shape-size distribution and fiber dimension.
Review
Biochemistry & Molecular Biology
Shivakalyani Adepu, Seeram Ramakrishna
Summary: The paper discusses the evolution of drug delivery systems, the limitations of conventional drug delivery, and the details of controlled drug delivery systems, including design considerations, classifications, and recent research findings on nano-drug delivery, targeted drug delivery, and smart drug delivery using intelligent biomaterials. The challenges and future directions in controlled drug delivery are also addressed in the conclusion.
Article
Chemistry, Analytical
Bhagavathi Chalil Najathulla, Atul Suresh Deshpande, Mudrika Khandelwal
Summary: This paper presents a simple method for displacement measurements using a smartphone camera and Matlab software to track and measure the deflection of an actuator. The method is validated with a microscope micrometer and successfully applied to measuring the deflection of an actuator based on poly (3,4-ethylene dioxythiophene) polystyrene sulfonate (PEDOT: PSS).
INSTRUMENTATION SCIENCE & TECHNOLOGY
(2022)
Article
Electrochemistry
Vikram Kishore Bharti, Anil Daliprasad Pathak, Chandra Shekhar Sharma, Mudrika Khandelwal
Summary: The study investigates the use of biodegradable and environmentally friendly carbonized bacterial cellulose (CBC) and Mn2O3 as sulfur hosts in lithium-sulfur batteries. The results show that the battery exhibits high reversible capacity and good cycling performance, with promising electrochemical performance at high sulfur loading.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Urbashi Mahanta, Atul S. Deshpande, Mudrika Khandelwal
Summary: TiO2 nanoparticles decorated on silica nanoparticles exhibit significantly higher antibacterial activity even under low-power UV radiation. The best antibacterial activity is achieved with a molar ratio of SiO2:TiO2 = 2:1 (Si2Ti). At a concentration of 5 mg/mL, with only 1.66 mg/mL of active catalyst, Si2Ti sample achieved 100% killing of E. coli after 90 minutes of UV exposure. Si2Ti also showed good biocompatibility with more than 87% cell viability in fibroblast cells for 500 mu g/mL of the sample.
Review
Materials Science, Biomaterials
Aszad Alam, Rounik Karmakar, Aravind Kumar Rengan, Mudrika Khandelwal
Summary: Drug delivery and delivery systems play a crucial role in medical research, and nanofibers have proven to be significant in achieving controlled release of drugs at specific sites. This review explores the materials, techniques, modifications, drug release, applications, and challenges of nanofiber-based drug delivery systems. It highlights the potential of these systems in stimuli-responsive and dual drug delivery.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Energy & Fuels
Vikram Kishore Bharti, Chandra Shekhar Sharma, Mudrika Khandelwal
Summary: Metal-sulfur batteries have higher energy density compared to currently used lithium-ion batteries, but their commercialization is hindered by the insulating nature of sulfur and metal anode corrosion. In this study, a self-supported lithiated/potassiated carbon electrode derived from bacterial cellulose was used to replace the metal anode, resulting in a practical realization of metal (Li/K)-S batteries with excellent performance.
Article
Multidisciplinary Sciences
Shivakalyani Adepu, Mudrika Khandelwal
Summary: Bacterial cellulose modified in situ by adding PEG2000 affects the microstructure and drug release kinetics, increasing porosity and pore volume while decreasing specific surface area, without significant impact on crystallinity. The modification facilitates a burst release of drugs compared to pristine BC, highlighting possibilities for immediate and sustained drug release applications.
PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY
(2021)
Article
Polymer Science
Siju Cherikkattil Raghavan, Anju PV, Mudrika Khandelwal
Summary: High-efficiency oil-water separation can be achieved using a specially designed amphiphilic composite membrane made of recycled PS and BC. The composite membrane shows excellent water recovery rate and superior performance in separating oil and water. Structural and material properties of the membranes were studied to understand the mechanisms of oil-water separation.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)