期刊
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
卷 54, 期 11, 页码 765-771出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10601325.2017.1332467
关键词
Arm number; Amphiphilic polymer; Polyurethane; Micelles; Drug delivery
资金
- Scientific Research Foundation of Graduate School of Wuhan University of Science and Technology [JCX2015045]
- Hubei Province Natural Science Foundation [2010CDB03501]
- Open Project Program of Hubei Province Key Laboratory of Coal Conversion and New Carbon Materials [WKDM201105]
Amphiphilic polyurethanes based on methoxy poly(ethylene glycol) (mPEG) and poly(E-caprolactone) diol (PCL) with different arm numbers such as two, three and four were successfully synthesized. Their structures were confirmed by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance spectroscopy (H-1 NMR) and gel permeation chromatography (GPC). The effects of arm number on properties of amphiphilic polyurethanes were studied. Pyrene fluorescence probe technique and dynamic light scattering (DLS) analyses showed that the CMC value and the micellar size of the resultant amphiphilic polyurethanes decreased and the micellar stability against dilution enhanced with increasing the arm number of polyurethane. Using indometacin (IMC) as a model drug, the results indicated that the drug loading capacity and in vitro drug sustained release effect of polyurethane with four arms were better than those of polyurethanes with two and three arms.
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