Aβ inhibits SREBP-2 activation through Akt inhibition

Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

(2016) S A Shah et al.   MOLECULAR PSYCHIATRY

Aβ-Induced Insulin Resistance and the Effects of Insulin on the Cholesterol Synthesis Pathway and Aβ Secretion in Neural Cells

(2016) Dema Najem et al.   Neuroscience Bulletin

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

(2013) Nathalie Pierrot et al.   EMBO Molecular Medicine

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer’s disease

(2012) Elena Posse de Chaves   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

 -Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage

(2012) A. Mohamed et al.   JOURNAL OF NEUROSCIENCE

Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease

(2012) Ling Li et al.   MOLECULAR NEUROBIOLOGY

Amyloid-β Protein Modulates Insulin Signaling in Presynaptic Terminals

(2012) David Heras-Sandoval et al.   NEUROCHEMICAL RESEARCH

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Akt acutely activates the cholesterogenic transcription factor SREBP-2

(2011) Winnie Luu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen

(2011) Y. Yamauchi et al.   CANCER RESEARCH

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

(2011) A. Aqul et al.   JOURNAL OF NEUROSCIENCE

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

(2011) Shuko Takeda et al.   Molecular BioSystems

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Isoprenoids, small GTPases and Alzheimer's disease

(2010) Gero P. Hooff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lithium Improves Hippocampal Neurogenesis, Neuropathology and Cognitive Functions in APP Mutant Mice

(2010) Anna Fiorentini et al.   PLoS One

Akt Phosphorylates Sec24: New Clues into the Regulation of ER-to-Golgi Trafficking

(2010) Laura J. Sharpe et al.   TRAFFIC

The Akt–SREBP nexus: cell signaling meets lipid metabolism

(2010) James R. Krycer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Central nervous system: cholesterol turnover, brain development and neurodegeneration

(2009) John M. Dietschy   BIOLOGICAL CHEMISTRY

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif

(2009) Y.-K. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin down-regulates LDL-receptor expression independently of SREBP-2

(2008) Laura J. Sharpe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

24(S),25-Epoxycholesterol: A messenger for cholesterol homeostasis

(2008) Andrew J. Brown   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes

(2008) Brian D. Reed et al.   PLoS Genetics

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity

(2007) Kyu-Yong Lee et al.   TOXICOLOGY