Article
Biochemistry & Molecular Biology
Carolini Mendes, Anand Thirupathi, Rubya Pereira Zaccaron, Maria Eduarda Anastacio Borges Correa, Joao V. S. Bittencourt, Laura de Roch Casagrande, Anadhelly C. S. de Lima, Lara L. de Oliveira, Thiago A. M. de Andrade, Yaodong Gu, Paulo Emilio Feuser, Ricardo A. Machado-de-Avila, Paulo Cesar Lock Silveira
Summary: This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. The results demonstrate that the combination therapy group showed better results in anti-inflammation and tissue repair process compared to the single therapy group.
Article
Veterinary Sciences
Mahmoud Soliman, Ahmed Abdelrahiem Sadek, Hani Nasser Abdelhamid, Kamal Hussein
Summary: The study evaluated the impact of using graphene oxide (GO)-cellulose nanocomposite on skin wound healing through in vitro and in vivo investigations. The nanomaterial showed excellent cytocompatibility, enhanced cell migration, and promoted wound healing in rat skin wounds, suggesting its promising potential application in tissue regeneration.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Wenhao Hao, Huali Meng, Hui Li, Yan Zheng, Chunhong Song, Ziping Jiang, Xue Bai, Zhiyue Zhang, Lei Du, Pei Liu, Hao Wu
Summary: Diabetes impairs wound healing, but the local application of krill oil can accelerate diabetic wound healing by reversing inflammation, impaired collagen deposition, and suppressed neovascularization.
Article
Engineering, Biomedical
Fan Yang, Yijia Xue, Feilong Wang, Danni Guo, Yunjiao He, Xiao Zhao, Fanyu Yan, Yuqian Xu, Dandan Xia, Yunsong Liu
Summary: The study investigates the effects of introducing magnesium (Mg) and zinc (Zn) into methacrylate gelatin (GelMA) hydrogel on skin wounds. The GelMA/Mg/Zn hydrogel promotes the migration of skin cells, transformation of fibroblasts into myofibroblasts, and production of extracellular matrix. It also accelerates the healing process of skin defects in rats through collagen deposition, angiogenesis, and re-epithelialization. The study identifies that Mg2+ promotes the entry of Zn2+ into fibroblasts and induces their differentiation into myofibroblasts via the STAT3 signaling pathway.
BIOACTIVE MATERIALS
(2023)
Article
Cell & Tissue Engineering
WeiGuo Su, PingLi Wang, QiQiang Dong, ShengJun Li, ShuiWang Hu
Summary: Adipose-derived stem cells (ADSCs) have the potential for multidirectional differentiation and exhibit immunomodulatory effects similar to bone marrow mesenchymal stem cells. Overexpression of S100A8 promotes ADSC proliferation and differentiation, while inhibiting inflammation, thus improving skin wound healing.
REGENERATIVE THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Jiangjiang Ru, Qian Zhang, Shaowei Zhu, Junrong Cai, Yunfan He, Feng Lu
Summary: The study found that HEP-ADGF-AAM, a surface-modified heparin-loaded acellular adipose matrix (AAM) containing adipose-derived growth factors (ADGFs), can promote wound healing. HEP-ADGF-AAM not only induced adipocyte regeneration but also enhanced fibroblast migration, promoted vessel formation, accelerated wound closure, and enhanced wound epithelialization.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Ning Zeng, Hongbo Chen, Yiping Wu, Zeming Liu
Summary: Wound healing in the human body is a complex physiological regulation mechanism, with adipose stem cells playing an important role in regenerative medicine. Adipose stem cells are easy to obtain, high-yielding, rich in components and cytokines, and highly practical.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biology
Antonio Alma, Guya Diletta Marconi, Elena Rossi, Cristina Magnoni, Alessia Paganelli
Summary: Chronic wounds pose a challenge to clinicians and researchers, and studies are being conducted to assess the link between chronic ulcers and obesity.
Article
Engineering, Biomedical
Mohamadmahdi Samandari, Fariba Aghabaglou, Kristo Nuutila, Hossein Derakhshandeh, Yuteng Zhang, Yori Endo, Seth Harris, Lindsay Barnum, Craig Kreikemeier-Bower, Elmira Arab-Tehrany, Nicholas A. Peppas, Indranil Sinha, Ali Tamayol
Summary: Insufficient vascularization is a major obstacle to normal wound healing, but delivery of angiogenic factors like VEGF can modestly improve healing. Specialty delivery systems, such as MNAs and LJIs, play a crucial role in controlling drug distribution and enhancing wound healing. The effectiveness of these delivery systems has been confirmed both in vitro and in vivo, showing enhanced angiogenesis and accelerated wound healing.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Hao Cheng, Zhe Shi, Kan Yue, Xusheng Huang, Yichuan Xu, Chenghao Gao, Zhongqi Yao, Yu Shrike Zhang, Jian Wang
Summary: The study introduces a novel sprayable hydrogel wound dressing loaded with cerium oxide nanoparticles and an antimicrobial peptide, providing ROS-scavenging and antibacterial properties. By adopting a mussel-inspired strategy, the hydrogel exhibited improved binding affinity to wet skin surfaces and demonstrated excellent biocompatibility.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Jianghong Huang, Xiaoling Lei, Zhiwang Huang, Zhibin Rong, Haihang Li, Yixin Xie, Li Duan, Jianyi Xiong, Daping Wang, Shihui Zhu, Yujie Liang, Jianhao Wang, Jiang Xia
Summary: This study reports the development of an all-protein hydrogel material that promotes skin regeneration and wound healing with biocompatibility and degradability.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Engineering, Biomedical
Hanif Haidari, Richard Bright, Xanthe L. Strudwick, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: This study presents the development of a multifunctional thermo-responsive hydrogel utilizing ultra-small silver nanoparticles for controlled and optimized delivery of silver to infected wounds. The developed hydrogel showed significant elimination of S. aureus from mouse wounds, promoting cell proliferation and wound re-epithelization. The multifunctional properties of the AgNP thermoresponsive hydrogel offer great clinical potential in controlling bacterial infections and promoting wound healing.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Environmental
Ragavi Rajasekaran, Atul Kumar Ojha, Venkata Sundeep Seesala, Arman Kunwar Hansda, Nantu Dogra, Jhansi Lakshmi Parimi, Sabyasachi Roy, Ritobrata Goswami, Mamoni Banerjee, Santanu Dhara
Summary: The conductive electroactive properties of polyaniline make it a promising polymer for therapeutic applications. In this study, PANI was incorporated into a high silk fibroin loaded polycaprolactone fiber and characterized for its physico-chemical properties. The results showed that the prepared fiber exhibited improved mechanical stability, cellular compatibility, and wound healing properties compared to the control.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Donghui Bian, Yan Wu, Guodong Song
Summary: It is discovered that the extracellular matrix (ECM) plays a crucial role in organizing the in vivo signaling of growth factors (GFs) by precisely releasing them and modulating their intracellular signaling. This has motivated researchers to develop effective GF delivery systems. Particularly, basic fibroblast growth factor (bFGF) integrated into ECM-based mimetic systems has shown great potential in skin bioengineering by promoting re-epithelialization, neovascularization, skin regeneration, and wound healing. This review focuses on current advances in bFGF-loaded ECM-mimetic delivery systems for wound healing enhancement, including scaffolds, hydrogels, and artificial dermis, and highlights the role of ECM as a regulator of GF signaling and the significance of bFGF in wound healing. The integration of bFGF and ECM mimetic delivery systems is speculated to have a significant impact on future skin tissue regeneration in the clinical setting.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hiromi Kominato, Kohei Takeda, Koji Mizutani, Risako Mikami, Daisuke Kido, Prima Buranasin, Natsumi Saito, Shu Takemura, Keita Nakagawa, Toshiyuki Nagasawa, Takanori Iwata
Summary: The study found that metformin can improve delayed gingival wound healing in insulin-resistant prediabetes by accelerating the proliferation and migration of human gingival fibroblasts, thereby enhancing the Akt phosphorylation in the insulin signaling pathway.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Kenichi Tanaka, Hirokazu Takahashi, Sayaka Katagiri, Kazuyo Sasaki, Yujin Ohsugi, Kazuki Watanabe, Islam M. D. Rasadul, Keiichiro Mine, Seiho Nagafuchi, Takanori Iwata, Yuichiro Eguchi, Keizo Anzai
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Chemistry, Medicinal
Yuji Kato, Satoko Arakawa, Kazue Terasawa, Jin-ichi Inokuchi, Takanori Iwata, Shigeomi Shimizu, Tetsuro Watabe, Miki Hara-Yokoyama
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Takahiro Ikawa, Koji Mizutani, Takeaki Sudo, Chihiro Kano, Yuichi Ikeda, Tatsuya Akizuki, Hiroaki Kobayashi, Yuichi Izumi, Takanori Iwata
Summary: Electric ionic toothbrushes demonstrated significantly higher plaque removal rates than manual toothbrushes in the premolar and molar areas, while no significant difference was observed in the central incisor area.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Koji Mizutani, Hidehiro Shioyama, Takanori Matsuura, Risako Mikami, Kohei Takeda, Yuichi Izumi, Akira Aoki, Takanori Iwata
Summary: This study found that minimally invasive periodontal surgery using EMD in patients with and without diabetes mellitus can lead to similar levels of clinical attachment gain and bone fill. This is the first documented study of successful periodontal tissue regeneration in patients with diabetes mellitus.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yuichi Ikeda, Ayako Kawada, Daiki Tanaka, Eri Ikeda, Hiroaki Kobayashi, Takanori Iwata
Summary: The study found that patients had fewer complaints with M-USSC compared to P-USSC during supragingival scaling, with significant improvements in patient complaints when using M-USSC.
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2021)
Review
Chemistry, Physical
Shunsuke Fukuba, Munehiro Okada, Kohei Nohara, Takanori Iwata
Summary: This review provides a summary of available bone graft products worldwide and discusses the prospects of alloplastic bone substitutes in the market and trends.
Review
Biochemistry & Molecular Biology
Masahiro Hatasa, Sumiko Yoshida, Hirokazu Takahashi, Kenichi Tanaka, Yoshihito Kubotsu, Yujin Ohsugi, Takaharu Katagiri, Takanori Iwata, Sayaka Katagiri
Summary: Periodontal disease is an inflammatory disease caused by oral microorganisms, with studies showing it as a risk factor for systemic diseases. The relationship between NAFLD and periodontal disease remains unclear. Epidemiological studies suggest periodontal disease as a risk factor for NAFLD, with animal models showing acceleration of NAFLD progression by periodontopathic bacteria. Th17 may play a key role in explaining the relationship between the two diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Akira Aoki, Koji Mizutani, Risako Mikami, Yoichi Taniguchi, Yujin Ohsugi, Walter Meinzer, Yuichi Izumi, Takanori Iwata
Summary: Er:YAG laser-assisted pocket therapy can effectively and safely clean periodontal pockets, leading to significant clinical improvements in most cases without adverse side effects or complications.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Biochemistry & Molecular Biology
Peiya Lin, Hiromi Niimi, Yujin Ohsugi, Yosuke Tsuchiya, Tsuyoshi Shimohira, Keiji Komatsu, Anhao Liu, Takahiko Shiba, Akira Aoki, Takanori Iwata, Sayaka Katagiri
Summary: Periodontitis is an inflammatory disease that involves the destruction of periodontal tissues. A new murine model using ligation has been effective in simulating bone loss and tissue destruction. The activation of osteoclasts, upregulation of pro-inflammatory factors, and excessive immune response are key factors in periodontal disruption. Multiple genes play a role in the complexity of periodontitis pathogenesis. Novel treatment methods have shown promise in the ligature-induced periodontitis model in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hiroyuki Saida, Shunsuke Fukuba, Takahiko Shiba, Keiji Komatsu, Takanori Iwata, Hiroshi Nitta
Summary: This case report demonstrates a novel staged surgical approach for treating furcation defects with insufficient keratinized mucosa, which led to successful periodontal regeneration and clinical improvement.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Koji Mizutani, Prima Buranasin, Risako Mikami, Kohei Takeda, Daisuke Kido, Kazuki Watanabe, Shu Takemura, Keita Nakagawa, Hiromi Kominato, Natsumi Saito, Atsuhiko Hattori, Takanori Iwata
Summary: This review found that the adjunctive use of antioxidants in periodontal therapy can significantly improve periodontal parameters in patients with type 2 diabetes, especially in the group treated with melatonin. However, there is still limited research on this topic, and more well-designed RCTs are needed for further investigation.
Article
Biochemistry & Molecular Biology
Yuka Tanaka-Takemura, Yoshinori Arisaka, Masahiro Hakariya, Hiroki Masuda, Ryo Mikami, Ruriko Sekiya-Aoyama, Takanori Iwata, Tetsuya Yoda, Takashi Ono, Nobuhiko Yui
Summary: Surface properties of biomaterials, such as zeta potential and molecular mobility, play important roles in influencing macrophage responses. The zeta potential affects the initial spreading of cells, while molecular mobility governs the subsequent spreading process. Molecular mobility is the main factor modulating the inflammatory activity in macrophages.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Masahiro Hakariya, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Takanori Iwata, Nobuhiko Yui
Summary: Cancer cells respond to physical cues from the microenvironment by altering migration and chemosensitivity. The molecular mobility of polyrotaxane surfaces affects cellular spreading, migration, and chemosensitivity in lung, pancreatic, and breast cancer cells.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hiroki Masuda, Yoshinori Arisaka, Masahiro Hakariya, Takanori Iwata, Tetsuya Yoda, Nobuhiko Yui
Summary: This study evaluates the effects of molecular mobility of polyrotaxane surfaces on subcellular YAP localization and oxidative stress-induced cell senescence in human mesenchymal stem cells (HMSCs). The results suggest that the molecular mobility of polyrotaxane surfaces regulates subcellular YAP localization, thereby protecting HMSCs from oxidative stress-induced cell senescence. Applying the molecular mobility of polyrotaxane surfaces can provide insights into the prevention and treatment of diseases caused by oxidative stress.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Masahiro Hakariya, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Atsushi Tamura, Takanori Iwata, Nobuhiko Yui
Summary: Researchers have designed a bilayer hydrogel structure with PRX and collagen layers to achieve rapid and strong adhesion to target tissues. In in vivo experiments in mice, the bilayer hydrogel demonstrated superior adhesion properties.