期刊
DEVELOPMENTAL NEUROBIOLOGY
卷 75, 期 6, 页码 542-556出版社
WILEY-BLACKWELL
DOI: 10.1002/dneu.22256
关键词
zebrafish; retinotectal map; tectum; RGC; development
资金
- National Health and Medical Research Council (NHMRC) [1043044]
- International Postgraduate Research Scholarship
- Queensland Brain Institute
The zebrafish retinotectal projection provides an attractive model system for studying many aspects of topographic map formation and maintenance. Visual connections initially start to form between 3 and 5 days postfertilization, and remain plastic throughout the life of the fish. Zebrafish are easily manipulated surgically, genetically, and chemically, and a variety of molecular tools exist to enable visualization and control of various aspects of map development. Here, we review zebrafish retinotectal map formation, focusing particularly on the detailed structure and dynamics of the connections, the molecules that are important in map creation, and how activity regulates the maintenance of the map. (c) 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 542-556, 2015
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