期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 174, 期 -, 页码 119-129出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.06.005
关键词
Platinum(IV) complexes; Synthesis; Characterization; Cytotoxicity; Reduction; Lipophilicity
资金
- FFG - Austrian Research Promotion Agency
- Austrian Council for Research and Technology Development
- FWF [J 3577-B13]
- COST [CM1105]
The impact of the equatorial coordination sphere on the reduction behavior (i.e. rate of reduction) of platinum (IV) complexes with axial carboxylato ligands was studied. Moreover, the influence of equatorial ligands on the stability, lipophilicity and cytotoxicity of platinum(IV) compounds was evaluated. For this purpose, a series of platinum(IV) complexes featuring axial carboxylato ligands (succinic acid monoesters) was synthesized; anionic carboxylato (OAc-, oxalate) and halido (Cl-, Br-, I-) ligands served as leaving groups and am(m)ine carrier ligands were provided by monodentately (isopropylamine, ammine + cyclohexaneamine) or bidentately (ethane-1,2-diamine) coordinating am(m)ines. All platinum(IV) products were fully characterized based on elemental analysis, high resolution mass spectrometry and multinuclear (H-1, C-13, N-15, Pt-195) NMR spectroscopy as well as by X-ray diffraction in some cases. The rate of reduction in the presence of ascorbic acid was determined by NMR spectroscopy and the lipophilicity of the complexes was investigated by analytical reversed phase HPLC measurements. Cytotoxic properties were studied by means of a colorimetric microculture assay in three human cancer cell lines derived from cisplatin sensitive ovarian teratocarcinoma (CH1/PA-1) as well as cisplatin insensitive colon carcinoma (SW480) and non-small cell lung cancer (A549).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据