Article
Chemistry, Multidisciplinary
Senka Djakovic, Silvija Maracic, Jasmina Lapic, Eduard Kovalski, Alexander Hildebrandt, Heinrich Lang, Valerije Vrcek, Silvana Raic-Malic, Mario Cetina
Summary: Compounds containing ferrocenyl, triazole, and quinoline have potential biological activities, with direct bonding of triazole ring to ferrocene skeleton showing higher cytotoxicity and reactive oxygen species generation. This study aimed to investigate how small differences on molecules' surfaces influence their supramolecular assembly, through X-ray crystal structure analysis, electrochemical measurements, and computational analysis of ferrocene-quinoline conjugates. The research confirmed that solid-state structural properties are relevant for discussing electrochemistry and bioactivity, with derivatives having lower redox potential values indicating higher antioxidant capacity.
STRUCTURAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Sarah N. Spisak, Zheng Zhou, Shuyang Liu, Qi Xu, Zheng Wei, Kenta Kato, Yasutomo Segawa, Kenichiro Itami, Andrey Yu. Rogachev, Marina A. Petrukhina
Summary: The stepwise chemical reduction of a molecular warped nanographene allowed the isolation of three different reduced states, providing a unique series of nanosized carbanions for in-depth structural analysis. The 3D molecular electrostatic potential maps identified the negative charge localization at the central part of the nanographene surface, where selective coordination of Cs+ ions is confirmed crystallographically. The in-depth theoretical investigation revealed a complex response of the nanographene to the stepwise electron acquisition, resulting in notable changes in the electronic structure and site-dependent aromaticity of the resulting carbanions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Marcus Korb, Paul J. Low
Summary: In this study, the reaction between 2,2'-diiodo-1,1'-biphenyl and ethynyl ferrocene was investigated, resulting in the formation of the expected product 2,2'-bis(ferrocenylethynyl)-1,1'-biphenyl through Sonogashira cross-coupling reaction. Another product, 9-(ferrocenyl(ferrocenylethynyl)methylene)-9H-fluorene, was also formed as the major product via a cyclization process. Similar reactions using the 2,2'-diiodo-1,1'-diphenyl ether analogue led to the formation of the anticipated product 2,2'-bis(ferrocenylethynyl) substituted product. The mechanism leading to the formation of the major product was studied using a Pd/dppf catalyst combination, and the electrochemical properties of the products were also investigated.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Physical
Mousa Al-Noaimi, Firas F. Awwadi, Nayyef Aljaar, Ayman Hammoudeh, Raja Bader, Rawaa Al-Azzawi
Summary: This study synthesized and characterized ruthenium(II) solvato complexes with tridentate thioether-azoimine ligands, investigating their oxidation-reduction and catalytic properties. The findings were rationalized through calculations and experiments, providing insights into the electronic structure, redox properties, electronic excitations, and catalytic activity of the complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Mark R. Ringenberg, Marc Schnierle, Christina Sondermann
Summary: This passage describes the electrochemical behavior of three complexes [CpNi(dRpf)] (+), which exhibit one cathodic process and one anodic process. The cathodic process generates CpNiI for all three complexes, while the anodic process shows contributions from ferrocene and some delocalization onto the Ni ion.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Michael G. Papanikolaou, Sofia Hadjithoma, John K. Gallos, Haralampos N. Miras, John C. Plakatouras, Anastasios D. Keramidas, Themistoklis A. Kabanos
Summary: The study reports three novel manganese complexes that serve as effective catalysts for the oxidation of water to dioxygen, with potential applications in photosynthesis. The complexes were found to be high-spin d(5) systems capable of oxidizing Mn-II to Mn-IV.
Article
Chemistry, Inorganic & Nuclear
S. Abbas, Imtiaz-ud-Din, M. Mehmood, A. Raheel, R. Ayub, M. Zahid, M. N. Tahir
Summary: A series of ferrocenyl substituted hydrazones have been synthesized and characterized, showing good antimicrobial activity and free radical scavenging activity. Compound II is predicted to be the softest and compound VII the hardest, with compound II potentially being used as a synthon for further chemical reactions.
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Mousa Al-Noaimi, Esam Qnais, Firas F. Awwadi, Manal I. Alwahsh
Summary: In this study, four complexes were synthesized and characterized using various spectroscopic techniques. Complex 4 exhibited the strongest antinociceptive activity, significantly inhibiting pain induced by acetic acid. Compounds 2 and 4 showed strong antinociceptive effects, suggesting they are promising candidates for further investigation.
Article
Chemistry, Physical
Mohammed Bakir, Mark A. W. Lawrence, Junior Johnson, Colin McMillen
Summary: The study reported the structure characterization and electrochemical properties of fac-[Re(CO)(3)(kappa(2)-N-im,S-bptsc)Cl] (2) synthesized by reacting Re(CO)5Cl and benzophenone thiosemicarbazone in toluene with air. The authenticity of compound 2 was confirmed through elemental analysis, spectroscopic measurements, and X-ray crystallographic analysis, with findings of structural changes in its electrochemical behavior elucidated. Potential mechanisms for the oxidative and reductive electrochemical decomposition of 1 and 2 were proposed and found to be in good agreement with literature reports on related compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Marcus Korb, Xianming Liu, Sebastian Walz, Julia Mahrholdt, Alexey A. Popov, Heinrich Lang
Summary: The reaction chemistry of Fe-2(CO)(9) with ferrocenenyl dichlorophosphines of different substitution patterns was studied, leading to the formation of various novel coordination compounds. The geometric properties of ferrocenyls featuring 1,1'- and 1,2-substitution patterns were found to be distinct from phenyl-based analogues. X-ray single crystal solid state structures, and DFT calculations were utilized to confirm the results.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Ritika Kubba, Omprakash Yadav, Suman Maji, Natalia Fridman, Anil Kumar
Summary: This study reports the synthesis, characterizations, electrochemical properties, single crystal X-ray diffraction studies, and DFT calculations of highly fluorescent phosphorus corroles. Nine phosphorus corroles were successfully synthesized and well characterized. The phosphorus corroles showed strong absorption at 600 nm and exhibited unique fluorescent features, which could be beneficial for biological applications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Applied
Thammarat Aree
Summary: Phloretin, phlorizin, and ferulic acid in apples can be made more stable and soluble in water through encapsulation with cyclodextrin. This study provides insights into the complexes formed by beta-CD-PRT, beta-CD-PRZ, and alpha-CD-FEA. The results show that the complexes are thermodynamically stable, with the PRZ and FEA molecules inserting into the cavities of beta-CD and alpha-CD, respectively. This study confirms the potential use of cyclodextrins as stabilizers and solubilizers for food bioactive compounds.
Article
Biochemistry & Molecular Biology
Monika Kovacevic, Dora Markulin, Matea Zelenika, Marko Marjanovic, Marija Lovric, Denis Polancec, Marina Ivancic, Jasna Mrvcic, Kresimir Molcanov, Valentina Milasinovic, Suncica Roca, Ivan Kodrin, Lidija Barisic
Summary: Considering the importance of protein turns in biological events, efforts have been made to develop stable mimetics. In this study, homochiral conjugates of ferrocene-1,1'-diamine with various amino acids were prepared and their stable turn structures were characterized. Preliminary biological evaluation showed that one of the conjugates has potential to inhibit cell cycle progression, but further investigation is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Monika Kovacevic, Mojca Cakic Semencic, Kristina Radosevic, Kresimir Molcanov, Suncica Roca, Lucija Simunovic, Ivan Kodrin, Lidija Barisic
Summary: Peptidomimetics involve modifying natural peptides to develop drug-like compounds with higher activity and selectivity, aiming to mimic their 3D shape and biological functions while reducing limitations. Mimicking peptide alpha-helices, beta-sheets or turns is one common synthetic strategy. Among various reported tools for turn mimetic design, an approach using ferrocene templates has shown potential for inducing turn formation and reducing flexibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Abdul Qaiyum Ramle, Nadia Nabihah Mohd Yusof Chan, Min Phin Ng, Chun Hoe Tan, Kae Shin Sim, Edward R. T. Tiekink, Chee Chin Fei
Summary: Five new benz[e]indole pyrazolyl-substituted amides (2a-e) were synthesized in low to good yields via direct amide-coupling reaction. The molecular structures were determined by various spectroscopic methods. Molecular docking calculations revealed that compound 2e exhibited the highest toxicity against a human colorectal carcinoma cell line by binding to the DNA minor groove.
MOLECULAR DIVERSITY
(2023)
Editorial Material
Nanoscience & Nanotechnology
Luis Jesus Villarreal Gomez, Yanis Toledano Magana, Jose Manuel Cornejo Bravo, Ricardo Vera Graziano, Shengqdaiang Cai
Summary: This Special Issue focuses on the physiological processes that occur in tissue exposed to nanomaterials, such as cellular stress, immune responses, etc., providing important references and guidance for the application of nanotechnology in the biomedical field.
JOURNAL OF NANOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Martha L. Jimenez-Gonzalez, Juan Pablo F. Rebolledo-Chavez, Marisela Cruz-Ramirez, Rene Antano, Angel Mendoza, Narayan S. Hosmane, Lena Ruiz-Azuara, Jose Luis Hernandez-Lopez, Luis Ortiz-Frade
Summary: In this work, an electrochemical study of the Boron cage monomercaptoundecahydro-closo-dodecaborate [B12H11SH](2-) in solution and in a self-assembled monolayer over a gold electrode was conducted. The study revealed the interaction between the boron cage and the gold surface, formation of a self-assembled monolayer, and the reduction of active sites on the gold surface due to the presence of the boron cage. Bulkier thiols were found to enhance charge accumulation at the electrode-solution interface.
Article
Biochemistry & Molecular Biology
Yeshenia Figueroa-DePaz, Jaime Perez-Villanueva, Olivia Soria-Arteche, Diego Martinez-Otero, Virginia Gomez-Vidales, Luis Ortiz-Frade, Lena Ruiz-Azuara
Summary: Casiopeinas are a family of copper(II) coordination compounds with important antineoplastic effects and low toxicity in normal cells. This study reports the third generation compounds with bioactive secondary ligand and their synthesis, characterization, and antiproliferative activity. The compounds showed potential as templates for further experimental and theoretical research, with structure-activity relationships strongly influenced by the redox potential of copper(II) and molar volume of the complexes.
Review
Chemistry, Multidisciplinary
Roberto Luna-Vazquez-Gomez, Maria Evarista Arellano-Garcia, Yanis Toledano-Magana, Juan Carlos Garcia-Ramos, Patricia Radilla-Chavez, David Sergio Salas-Vargas, Francisco Casillas-Figueroa, Balam Ruiz-Ruiz, Alexey Pestryakov, Nina Bogdanchikova
Summary: This study systematically investigates the hemolytic properties of Argovit(TM) silver nanoparticles, revealing a bell-shaped hemolysis curve for human erythrocytes. The hemolysis profiles of AgNPs and AgNO3 changed significantly with decreasing pH. Hemolysis of diabetic donor erythrocytes was slightly higher than that of healthy donor erythrocytes.
Article
Multidisciplinary Sciences
Salvador E. Meneses-Sagrero, Luisa A. Rascon-Valenzuela, Juan C. Garcia-Ramos, Wagner Vilegas, Aldo A. Arvizu-Flores, Rogerio R. Sotelo-Mundo, Ramon E. Robles-Zepeda
Summary: This study evaluated the inhibitory capacity of cardenolides from Asclepias subulata on Na+/K+-ATPase activity and explored their possible mechanisms of action. The results showed that calotropin and C3OG significantly inhibited Na+/K+-ATPase activity and interacted with key residues. These findings provide novel evidence for further studies on C3OG as an anticancer molecule in vitro and in vivo.
Article
Chemistry, Inorganic & Nuclear
A. Y. Flores-Ramirez, S. Aguilera-Aguirre, M. A. Chacon-Lopez, L. A. Ortiz-Frade, R. Antano-Lopez, A. Alvarez-Lopez, A. Rodriguez-Lopez, U. M. Lopez-Garcia
Summary: MNPs were synthesized using the asymmetrical potential pulses method and subsequently functionalized with chitosan. The physicochemical and electrochemical characterization showed that chitosan provided stability to the MNPs and enhanced their electron transfer capability, making them useful in various fields.
JOURNAL OF CLUSTER SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Jesus Gabriel Gonzalez-Vega, Juan Carlos Garcia-Ramos, Rocio Alejandra Chavez-Santoscoy, Javier Emmanuel Castillo-Quinones, Maria Evarista Arellano-Garcia, Yanis Toledano-Magana
Summary: Nanomaterials, especially silver nanoparticles, have shown remarkable results in various industrial and scientific areas. However, the lack of standardized toxicity models has generated controversy and hindered nanotoxicology research progress. This review summarizes recent reports on the toxicity of silver nanoparticles in cellular respiratory system models and emphasizes the importance of physiologically relevant models.
Article
Electrochemistry
M. L. Jimenez-Gonzalez, J. J. Gomez-Guzman, Rene Antano-Lopez, Luis Ortiz-Frade
Summary: This study reports the improvement of electron transfer of superoxide dismutase (SOD) in a typical electrochemical biosensor by modifying gold electrodes with cysteine. The adsorption processes during the enzyme immobilization were investigated through differential capacitance studies and theoretical electrostatic potential calculations. Results provide insights into the adsorption orientation of SOD according to experimental data.
ELECTROCHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Brando Fabian Bringas-Burgos, Karla Guadalupe Martinez-Robinson, Yanis Toledano-Magana, Juan Carlos Garcia-Ramos, Maribel Ovando-Martinez, Jesus Lopez-Elias
Summary: Nowadays, LED provides an alternative light source to sunlight with specific intensity and wavelength to promote plant growth. LED can also stimulate the production of pharmaceutical metabolites. This study analyzed the cultivation of oregano in a floating root hydroponic system supplemented by full-spectrum LED artificial light. The results showed that hydroponic conditions and full spectrum LED effectively modified the essential oil composition of oregano, which exhibited significant inhibition of human colorectal cancer cell growth.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Polymer Science
Egla Yareth Bivian-Castro, Abraham Zepeda-Navarro, Jorge Luis Guzman-Mar, Marcos Flores-Alamo, Brenda Mata-Ortega
Summary: The novel [Cuphen(VBA)(2)H2O] complex was used to preorganize a new ion-imprinted polymer (IIP) by leaching Cu(II) from the molecular imprinted polymer (MIP). The characterization results showed that the IIP has higher surface area and is nonsoluble in water and polar solvents. The adsorption capacity of the IIP for copper(II) ions was determined, and the stability of the Cu-IIP complex was found to be higher than the Ni-IIP complex.
Article
Pharmacology & Pharmacy
Evgenii V. Plotnikov, Maria S. Tretayakova, Diana Garibo-Ruiz, Ana G. Rodriguez-Hernandez, Alexey N. Pestryakov, Yanis Toledano-Magana, Nina Bogdanchikova
Summary: This study synthesized silver nanoparticles by irradiation treatment of silver nitrate solution with various stabilizers in a liquid medium and investigated their cytotoxic properties against cancer cells. The results showed that the silver nanoparticles had a dose-dependent cytotoxic effect on tumor cells, and the particles obtained with the combination of polyvinylpyrrolidone and collagen hydrolysate exhibited stronger cytotoxicity compared to samples stabilized with only collagen or only polyvinylpyrrolidone. The AgNPs formulation prepared with a mixture of PVP and PH showed significantly higher activity than other reported formulations.
Article
Biochemistry & Molecular Biology
Yanis Toledano-Magana, Mario Nequiz, Lucia Margarita Valenzuela-Salas, Jessica J. Sanchez-Garcia, Rodrigo Galindo-Murillo, Juan Carlos Garcia-Ramos, Elena I. Klimova
Summary: This study describes the amoebicidal activity of five 2-(Z-2,3-diferrocenylvinyl)-4X-4,5-dihydrooxazole derivatives on Entamoeba histolytica trophozoites, as well as the physicochemical, experimental, and theoretical properties that can be used to describe the antiproliferative activity. The growth inhibition capacity of these organometallic compounds is strongly related to a fine balance between the compounds' redox potential and hydrophilic character. Compound 3d presents the highest antiproliferative activity of the series with an IC50 of 23 μM. However, the results of this work provide a pipeline to improve the amoebicidal activity of these compounds through the directed modification of their electronic environment.
Article
Chemistry, Physical
Egla Yareth Bivian-Castro, Marcos Flores-Alamo, Roberto Escudero, Virginia Gomez-Vidal, Jose J. N. Segoviano-Garfias, Jesus Castaneda-Contreras, Quetzalcoatl Enrique Saavedra-Arroyo
Summary: A new Cu(II) paddle-wheel-like complex with 4-vinylbenzoate was synthesized and characterized by various analyses. X-ray crystal diffraction revealed the geometric structure of the complex, with copper ions bound to oxygen atoms from the 4-vinylbenzoate ligand. The complex remained structurally intact when exposed to humid air, but showed a gradual replacement of coordinated acetonitrile by water molecules. EPR spectra indicated the presence of monomeric and dimeric copper species, and magnetic studies suggested oxygen absorption capacity of the Cu(II)-vba complex.
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)