期刊
JOURNAL OF INFLAMMATION-LONDON
卷 14, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12950-017-0159-2
关键词
Stimulator of Interferon Genes (STING); Double-stranded DNA sensor; Cyclic dinucleotide; cGAS
类别
资金
- Biotechnology and Biological Sciences Research Council [BB/L000830/1]
- British Heart Foundation [PG/13/80/30443, PG/16/44/32146]
- Biotechnology and Biological Sciences Research Council [BB/L000830/1] Funding Source: researchfish
- British Heart Foundation [PG/16/44/32146, PG/13/80/30443] Funding Source: researchfish
The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named STimulator of INterferon Genes (STING). STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. This review will summarise the recent structural and functional findings of STING, and discuss how STING research has promoted the development of novel therapeutic approaches and experimental tools to improve treatment of tumour and autoimmune diseases.
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